Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors
(2012) In Bioorganic & Medicinal Chemistry Letters 22(5). p.1944-1948- Abstract
A series of 1,6-naphthyridine-based compounds was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. Structure-based chemical modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/6f2b2247-f25f-466f-8150-f906c21e17fd
- author
- Bauer, Udo ; Giordanetto, Fabrizio ; Bauer, Martin ; O'Mahony, Gavin ; Johansson, Kjell E ; Knecht, Wolfgang LU ; Hartleib-Geschwindner, Judith ; Carlsson, Eva Töppner and Enroth, Cristofer
- publishing date
- 2012-03-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Antipsychotic Agents/chemistry, Humans, Models, Molecular, Naphthyridines/chemistry, Nitriles/chemistry, Phosphodiesterase Inhibitors/chemistry, Phosphoric Diester Hydrolases/chemistry, Structure-Activity Relationship
- in
- Bioorganic & Medicinal Chemistry Letters
- volume
- 22
- issue
- 5
- pages
- 1944 - 1948
- publisher
- Elsevier
- external identifiers
-
- scopus:84857355907
- pmid:22321214
- ISSN
- 0960-894X
- DOI
- 10.1016/j.bmcl.2012.01.046
- language
- English
- LU publication?
- no
- id
- 6f2b2247-f25f-466f-8150-f906c21e17fd
- date added to LUP
- 2020-07-17 14:10:24
- date last changed
- 2024-08-09 00:14:36
@article{6f2b2247-f25f-466f-8150-f906c21e17fd, abstract = {{<p>A series of 1,6-naphthyridine-based compounds was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. Structure-based chemical modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.</p>}}, author = {{Bauer, Udo and Giordanetto, Fabrizio and Bauer, Martin and O'Mahony, Gavin and Johansson, Kjell E and Knecht, Wolfgang and Hartleib-Geschwindner, Judith and Carlsson, Eva Töppner and Enroth, Cristofer}}, issn = {{0960-894X}}, keywords = {{Antipsychotic Agents/chemistry; Humans; Models, Molecular; Naphthyridines/chemistry; Nitriles/chemistry; Phosphodiesterase Inhibitors/chemistry; Phosphoric Diester Hydrolases/chemistry; Structure-Activity Relationship}}, language = {{eng}}, month = {{03}}, number = {{5}}, pages = {{1944--1948}}, publisher = {{Elsevier}}, series = {{Bioorganic & Medicinal Chemistry Letters}}, title = {{Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors}}, url = {{http://dx.doi.org/10.1016/j.bmcl.2012.01.046}}, doi = {{10.1016/j.bmcl.2012.01.046}}, volume = {{22}}, year = {{2012}}, }