Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Diffuse fluorescence tomography for photodynamic therapy of tumors

Šušnjar, Stefan LU orcid ; Ghauri, Daniyal ; Thomasson, Björn ; Sekar, Sanathana Konugolu Venkata ; Andersson-Engels, Stefan ; Swartling, Johannes and Reistad, Nina LU orcid (2025) SPIE Photonics West 2025 13320.
Abstract
We develop and validate diffuse optical tomography methods based on interstitial fluorescence measurements for the reconstruction of fluorescent photosensitizing drug spatial distribution. We propose another phase in the tomographic reconstruction algorithm resulting in quantitatively more accurate reconstruction. This quantitative information can be used to monitor the temporal evolution of the photosensitizing drug concentration in tumor tissue with a final goal to predict the photodynamic treatment outcome and adjust the light dose in real time during the treatment. Capabilities and limitations of the developed reconstruction methods are analyzed in numerical simulations. Experimental validation is conducted on prostate tissue-mimicking... (More)
We develop and validate diffuse optical tomography methods based on interstitial fluorescence measurements for the reconstruction of fluorescent photosensitizing drug spatial distribution. We propose another phase in the tomographic reconstruction algorithm resulting in quantitatively more accurate reconstruction. This quantitative information can be used to monitor the temporal evolution of the photosensitizing drug concentration in tumor tissue with a final goal to predict the photodynamic treatment outcome and adjust the light dose in real time during the treatment. Capabilities and limitations of the developed reconstruction methods are analyzed in numerical simulations. Experimental validation is conducted on prostate tissue-mimicking phantoms with inclusions containing photosensitizer verteporfin, using a laser light delivery and collection system designed for clinical use. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
diffuse optical tomography,, fluorescence, photodynamic therapy, hybrid phantoms, reconstruction, photosensitizing drug, inverse problem
host publication
SPIE Photonics West 2025 : Proceedings Volume 13320, Biomedical Light Scattering XV - Proceedings Volume 13320, Biomedical Light Scattering XV
volume
13320
publisher
SPIE
conference name
SPIE Photonics West 2025
conference location
San Fransisco, United States
conference dates
2025-01-25 - 2025-03-30
external identifiers
  • scopus:105002311677
DOI
10.1117/12.3041146
language
English
LU publication?
yes
id
6f52677d-d452-4b81-b33d-e630393f3a98
date added to LUP
2025-03-23 13:42:48
date last changed
2025-05-12 04:01:05
@inproceedings{6f52677d-d452-4b81-b33d-e630393f3a98,
  abstract     = {{We develop and validate diffuse optical tomography methods based on interstitial fluorescence measurements for the reconstruction of fluorescent photosensitizing drug spatial distribution. We propose another phase in the tomographic reconstruction algorithm resulting in quantitatively more accurate reconstruction. This quantitative information can be used to monitor the temporal evolution of the photosensitizing drug concentration in tumor tissue with a final goal to predict the photodynamic treatment outcome and adjust the light dose in real time during the treatment. Capabilities and limitations of the developed reconstruction methods are analyzed in numerical simulations. Experimental validation is conducted on prostate tissue-mimicking phantoms with inclusions containing photosensitizer verteporfin, using a laser light delivery and collection system designed for clinical use.}},
  author       = {{Šušnjar, Stefan and Ghauri, Daniyal and Thomasson, Björn and Sekar, Sanathana Konugolu Venkata and Andersson-Engels, Stefan and Swartling, Johannes and Reistad, Nina}},
  booktitle    = {{SPIE Photonics West 2025 : Proceedings Volume 13320, Biomedical Light Scattering XV}},
  keywords     = {{diffuse optical tomography,; fluorescence; photodynamic therapy; hybrid phantoms; reconstruction; photosensitizing drug; inverse problem}},
  language     = {{eng}},
  month        = {{03}},
  publisher    = {{SPIE}},
  title        = {{Diffuse fluorescence tomography for photodynamic therapy of tumors}},
  url          = {{http://dx.doi.org/10.1117/12.3041146}},
  doi          = {{10.1117/12.3041146}},
  volume       = {{13320}},
  year         = {{2025}},
}