Neutrophil extracellular traps in colorectal cancer progression and metastasis
(2021) In International Journal of Molecular Sciences 22(14).- Abstract
Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.
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https://lup.lub.lu.se/record/6f6b349c-f181-490d-aeea-591329fa8e8b
- author
- Khan, Umama ; Chowdhury, Sabrina ; Billah, Md Morsaline ; Islam, Kazi Mohammed Didarul ; Thorlacius, Henrik LU and Rahman, Milladur LU
- organization
- publishing date
- 2021-07-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Colorectal cancer, Extracellular DNA, Metastasis, Neutrophil, Therapeutics
- in
- International Journal of Molecular Sciences
- volume
- 22
- issue
- 14
- article number
- 7260
- publisher
- MDPI AG
- external identifiers
-
- scopus:85109019004
- pmid:34298878
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms22147260
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: Cancerfonden (19 0428 Pj). Acknowledgments: Graphical images were prepared using digital contents from SERVIER MEDICAL ART (https://smart.servier.com) covered by CC BY license. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
- id
- 6f6b349c-f181-490d-aeea-591329fa8e8b
- date added to LUP
- 2021-07-14 13:46:42
- date last changed
- 2024-04-20 09:26:19
@article{6f6b349c-f181-490d-aeea-591329fa8e8b, abstract = {{<p>Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.</p>}}, author = {{Khan, Umama and Chowdhury, Sabrina and Billah, Md Morsaline and Islam, Kazi Mohammed Didarul and Thorlacius, Henrik and Rahman, Milladur}}, issn = {{1661-6596}}, keywords = {{Colorectal cancer; Extracellular DNA; Metastasis; Neutrophil; Therapeutics}}, language = {{eng}}, month = {{07}}, number = {{14}}, publisher = {{MDPI AG}}, series = {{International Journal of Molecular Sciences}}, title = {{Neutrophil extracellular traps in colorectal cancer progression and metastasis}}, url = {{http://dx.doi.org/10.3390/ijms22147260}}, doi = {{10.3390/ijms22147260}}, volume = {{22}}, year = {{2021}}, }