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Neutrophil extracellular traps in colorectal cancer progression and metastasis

Khan, Umama ; Chowdhury, Sabrina ; Billah, Md Morsaline ; Islam, Kazi Mohammed Didarul ; Thorlacius, Henrik LU and Rahman, Milladur LU orcid (2021) In International Journal of Molecular Sciences 22(14).
Abstract

Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colorectal cancer, Extracellular DNA, Metastasis, Neutrophil, Therapeutics
in
International Journal of Molecular Sciences
volume
22
issue
14
article number
7260
publisher
MDPI AG
external identifiers
  • scopus:85109019004
  • pmid:34298878
ISSN
1661-6596
DOI
10.3390/ijms22147260
language
English
LU publication?
yes
additional info
Funding Information: Cancerfonden (19 0428 Pj). Acknowledgments: Graphical images were prepared using digital contents from SERVIER MEDICAL ART (https://smart.servier.com) covered by CC BY license. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
id
6f6b349c-f181-490d-aeea-591329fa8e8b
date added to LUP
2021-07-14 13:46:42
date last changed
2024-04-20 09:26:19
@article{6f6b349c-f181-490d-aeea-591329fa8e8b,
  abstract     = {{<p>Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.</p>}},
  author       = {{Khan, Umama and Chowdhury, Sabrina and Billah, Md Morsaline and Islam, Kazi Mohammed Didarul and Thorlacius, Henrik and Rahman, Milladur}},
  issn         = {{1661-6596}},
  keywords     = {{Colorectal cancer; Extracellular DNA; Metastasis; Neutrophil; Therapeutics}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{14}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Neutrophil extracellular traps in colorectal cancer progression and metastasis}},
  url          = {{http://dx.doi.org/10.3390/ijms22147260}},
  doi          = {{10.3390/ijms22147260}},
  volume       = {{22}},
  year         = {{2021}},
}