Prevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes : Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Children
Lindgren, Marie LU ; Norström, Fredrik ; Persson, Martina ; Elding Larsson, Helena LU ; Forsander, Gun ; Åkesson, Karin ; Samuelsson, Ulf ; Ludvigsson, Johnny and Carlsson, Annelie LU
(2024)
In Diabetes Care
47(4).
p.756-760
- Abstract
OBJECTIVE: To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines.
RESEARCH DESIGN AND METHODS: The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes Diagnosis study in Sweden.
RESULTS: The prevalence of biopsy-proven CD was 9.8%, of which 58.2% already had a CD diagnosis before or at T1D onset. Almost all, 95.9%, were diagnosed with CD within 5 years after the T1D diagnosis. Younger age at the T1D diagnosis and being homozygote for DQ2 increased the risk of CD after T1D, but... (More)
OBJECTIVE: To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines.
RESEARCH DESIGN AND METHODS: The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes Diagnosis study in Sweden.
RESULTS: The prevalence of biopsy-proven CD was 9.8%, of which 58.2% already had a CD diagnosis before or at T1D onset. Almost all, 95.9%, were diagnosed with CD within 5 years after the T1D diagnosis. Younger age at the T1D diagnosis and being homozygote for DQ2 increased the risk of CD after T1D, but neither sex nor diabetes-related autoantibodies were associated with the risk.
CONCLUSIONS: Age at and time after diabetes diagnosis should be considered in screening guidelines for CD in children with T1D.
(Less)
- author
- Lindgren, Marie
LU
; Norström, Fredrik
; Persson, Martina
; Elding Larsson, Helena
LU
; Forsander, Gun
; Åkesson, Karin
; Samuelsson, Ulf
; Ludvigsson, Johnny
and Carlsson, Annelie
LU
- organization
- publishing date
- 2024-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Child, Adolescent, Humans, Infant, Diabetes Mellitus, Type 1/complications, Celiac Disease/complications, Sweden/epidemiology, Longitudinal Studies, Prevalence, Cohort Studies, Autoantibodies
- in
- Diabetes Care
- volume
- 47
- issue
- 4
- pages
- 5 pages
- publisher
- American Diabetes Association
- external identifiers
-
- scopus:85188894512
- pmid:38363973
- ISSN
- 1935-5548
- DOI
- 10.2337/dc23-1671
- language
- English
- LU publication?
- yes
- additional info
- © 2024 by the American Diabetes Association.
- id
- 6f77e4e1-8bf7-4bb4-893f-d4e6284b4a91
- date added to LUP
- 2024-03-28 07:52:22
- date last changed
- 2024-04-16 15:40:36
@article{6f77e4e1-8bf7-4bb4-893f-d4e6284b4a91,
abstract = {{<p>OBJECTIVE: To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines.</p><p>RESEARCH DESIGN AND METHODS: The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes Diagnosis study in Sweden.</p><p>RESULTS: The prevalence of biopsy-proven CD was 9.8%, of which 58.2% already had a CD diagnosis before or at T1D onset. Almost all, 95.9%, were diagnosed with CD within 5 years after the T1D diagnosis. Younger age at the T1D diagnosis and being homozygote for DQ2 increased the risk of CD after T1D, but neither sex nor diabetes-related autoantibodies were associated with the risk.</p><p>CONCLUSIONS: Age at and time after diabetes diagnosis should be considered in screening guidelines for CD in children with T1D.</p>}},
author = {{Lindgren, Marie and Norström, Fredrik and Persson, Martina and Elding Larsson, Helena and Forsander, Gun and Åkesson, Karin and Samuelsson, Ulf and Ludvigsson, Johnny and Carlsson, Annelie}},
issn = {{1935-5548}},
keywords = {{Child; Adolescent; Humans; Infant; Diabetes Mellitus, Type 1/complications; Celiac Disease/complications; Sweden/epidemiology; Longitudinal Studies; Prevalence; Cohort Studies; Autoantibodies}},
language = {{eng}},
month = {{04}},
number = {{4}},
pages = {{756--760}},
publisher = {{American Diabetes Association}},
series = {{Diabetes Care}},
title = {{Prevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes : Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Children}},
url = {{http://dx.doi.org/10.2337/dc23-1671}},
doi = {{10.2337/dc23-1671}},
volume = {{47}},
year = {{2024}},
}