Pancreatic Cancer Organoids : An Emerging Platform for Precision Medicine?
(2023) In Biomedicines 11(3).- Abstract
Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between in vitro and in vivo models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards... (More)
Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between in vitro and in vivo models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards precision medicine for pancreatic cancer.
(Less)
- author
- Sereti, Evangelia LU ; Papapostolou, Irida and Dimas, Konstantinos
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pancreatic cancer, pancreatic organoids, precision medicine
- in
- Biomedicines
- volume
- 11
- issue
- 3
- article number
- 890
- publisher
- MDPI AG
- external identifiers
-
- pmid:36979869
- scopus:85151559934
- ISSN
- 2227-9059
- DOI
- 10.3390/biomedicines11030890
- language
- English
- LU publication?
- yes
- id
- 6f8aeb30-a0aa-4134-bb93-fa4dcc8cbfe6
- date added to LUP
- 2023-05-23 11:23:33
- date last changed
- 2024-04-19 22:05:22
@article{6f8aeb30-a0aa-4134-bb93-fa4dcc8cbfe6, abstract = {{<p>Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between in vitro and in vivo models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards precision medicine for pancreatic cancer.</p>}}, author = {{Sereti, Evangelia and Papapostolou, Irida and Dimas, Konstantinos}}, issn = {{2227-9059}}, keywords = {{pancreatic cancer; pancreatic organoids; precision medicine}}, language = {{eng}}, number = {{3}}, publisher = {{MDPI AG}}, series = {{Biomedicines}}, title = {{Pancreatic Cancer Organoids : An Emerging Platform for Precision Medicine?}}, url = {{http://dx.doi.org/10.3390/biomedicines11030890}}, doi = {{10.3390/biomedicines11030890}}, volume = {{11}}, year = {{2023}}, }