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Pancreatic Cancer Organoids : An Emerging Platform for Precision Medicine?

Sereti, Evangelia LU ; Papapostolou, Irida and Dimas, Konstantinos (2023) In Biomedicines 11(3).
Abstract

Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between in vitro and in vivo models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards... (More)

Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between in vitro and in vivo models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards precision medicine for pancreatic cancer.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pancreatic cancer, pancreatic organoids, precision medicine
in
Biomedicines
volume
11
issue
3
article number
890
publisher
MDPI AG
external identifiers
  • pmid:36979869
  • scopus:85151559934
ISSN
2227-9059
DOI
10.3390/biomedicines11030890
language
English
LU publication?
yes
id
6f8aeb30-a0aa-4134-bb93-fa4dcc8cbfe6
date added to LUP
2023-05-23 11:23:33
date last changed
2024-04-19 22:05:22
@article{6f8aeb30-a0aa-4134-bb93-fa4dcc8cbfe6,
  abstract     = {{<p>Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between in vitro and in vivo models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards precision medicine for pancreatic cancer.</p>}},
  author       = {{Sereti, Evangelia and Papapostolou, Irida and Dimas, Konstantinos}},
  issn         = {{2227-9059}},
  keywords     = {{pancreatic cancer; pancreatic organoids; precision medicine}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{MDPI AG}},
  series       = {{Biomedicines}},
  title        = {{Pancreatic Cancer Organoids : An Emerging Platform for Precision Medicine?}},
  url          = {{http://dx.doi.org/10.3390/biomedicines11030890}},
  doi          = {{10.3390/biomedicines11030890}},
  volume       = {{11}},
  year         = {{2023}},
}