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The dynamics of change in striatal activity following updating training

Kuhn, Simone; Schmiedek, Florian; Noack, Hannes; Wenger, Elisabeth; Bodammer, Nils C.; Lindenberger, Ulman and Lövdén, Martin LU (2013) In Human Brain Mapping 34(7). p.1530-1541
Abstract
Increases in striatal activity have been suggested to mediate training-related improvements in working-memory ability. We investigated the temporal dynamics of changes in task-related brain activity following training of working memory. Participants in an experimental group and an active control group, trained on easier tasks of a constant difficulty in shorter sessions than the experimental group, were measured before, after about 1 week, and after more than 50 days of training. In the experimental group an initial increase of working-memory related activity in the functionally defined right striatum and anatomically defined right and left putamen was followed by decreases, resulting in an inverted u-shape function that relates activity... (More)
Increases in striatal activity have been suggested to mediate training-related improvements in working-memory ability. We investigated the temporal dynamics of changes in task-related brain activity following training of working memory. Participants in an experimental group and an active control group, trained on easier tasks of a constant difficulty in shorter sessions than the experimental group, were measured before, after about 1 week, and after more than 50 days of training. In the experimental group an initial increase of working-memory related activity in the functionally defined right striatum and anatomically defined right and left putamen was followed by decreases, resulting in an inverted u-shape function that relates activity to training over time. Activity increases in the striatum developed slower in the active control group, observed at the second posttest after more than 50 days of training. In the functionally defined left striatum, initial activity increases were maintained after more extensive training and the pattern was similar for the two groups. These results shed new light on the relation between activity in the striatum (especially the putamen) and the effects of working memory training, and illustrate the importance of multiple measurements for interpreting effects of training on regional brain activity. Hum Brain Mapp, 2013. (c) 2012 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
working memory, striatum, training, fMRI
in
Human Brain Mapping
volume
34
issue
7
pages
1530 - 1541
publisher
Wiley-Blackwell
external identifiers
  • wos:000320407500003
  • scopus:84879223802
ISSN
1065-9471
DOI
10.1002/hbm.22007
language
English
LU publication?
yes
id
7031425b-901f-417f-b085-e59855b10892 (old id 3987194)
date added to LUP
2013-09-02 10:43:07
date last changed
2019-05-14 01:18:06
@article{7031425b-901f-417f-b085-e59855b10892,
  abstract     = {Increases in striatal activity have been suggested to mediate training-related improvements in working-memory ability. We investigated the temporal dynamics of changes in task-related brain activity following training of working memory. Participants in an experimental group and an active control group, trained on easier tasks of a constant difficulty in shorter sessions than the experimental group, were measured before, after about 1 week, and after more than 50 days of training. In the experimental group an initial increase of working-memory related activity in the functionally defined right striatum and anatomically defined right and left putamen was followed by decreases, resulting in an inverted u-shape function that relates activity to training over time. Activity increases in the striatum developed slower in the active control group, observed at the second posttest after more than 50 days of training. In the functionally defined left striatum, initial activity increases were maintained after more extensive training and the pattern was similar for the two groups. These results shed new light on the relation between activity in the striatum (especially the putamen) and the effects of working memory training, and illustrate the importance of multiple measurements for interpreting effects of training on regional brain activity. Hum Brain Mapp, 2013. (c) 2012 Wiley Periodicals, Inc.},
  author       = {Kuhn, Simone and Schmiedek, Florian and Noack, Hannes and Wenger, Elisabeth and Bodammer, Nils C. and Lindenberger, Ulman and Lövdén, Martin},
  issn         = {1065-9471},
  keyword      = {working memory,striatum,training,fMRI},
  language     = {eng},
  number       = {7},
  pages        = {1530--1541},
  publisher    = {Wiley-Blackwell},
  series       = {Human Brain Mapping},
  title        = {The dynamics of change in striatal activity following updating training},
  url          = {http://dx.doi.org/10.1002/hbm.22007},
  volume       = {34},
  year         = {2013},
}