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A Swedish approach to the prevention of type 1 diabetes

Elding Larsson, Helena LU (2016) In Pediatric Diabetes 17(S22). p.73-77
Abstract

Background: The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. Objectives: Ongoing prediction and prevention studies in Skåne, Sweden are described. Methods: During September 2000 to August 2004, 35 000 children were screened at birth for genetic type 1 diabetes risk in the Diabetes Prediction in Skåne Study (DiPiS). In August 2004, the screening continued within the Enviromnental Determinants of Diabetes in the Young study (TEDDY). In the clinical trial Diabetes Prevention – Immune Tolerance... (More)

Background: The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. Objectives: Ongoing prediction and prevention studies in Skåne, Sweden are described. Methods: During September 2000 to August 2004, 35 000 children were screened at birth for genetic type 1 diabetes risk in the Diabetes Prediction in Skåne Study (DiPiS). In August 2004, the screening continued within the Enviromnental Determinants of Diabetes in the Young study (TEDDY). In the clinical trial Diabetes Prevention – Immune Tolerance (DiAPREV-IT), children with multiple islet autoimmunity have been included to investigate if immune tolerance with Alum-formulated GAD65 may prevent further beta-cell loss. Results: In DiPiS and TEDDY, a large number of children are followed in order to find the factors that trigger the autoimmune process leading to type 1 diabetes. Children followed in the studies develop diabetes at an early stage of disease, with few symptoms and a low frequency of diabetes ketoacidosis. DiAPREV-IT is still blinded and results will be available in December 2016. Conclusion: Large prospective studies will be needed to understand the complex process leading to type 1 diabetes. Secondary prevention may be possible in children with islet autoimmunity, but the studies are complicated by the variability of glucose metabolism and beta-cell loss.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pediatric diabetes, prevention, Sweden, type 1 diabetes mellitus
in
Pediatric Diabetes
volume
17
issue
S22
pages
5 pages
publisher
Wiley-Blackwell
external identifiers
  • Scopus:84978371847
ISSN
1399-543X
DOI
10.1111/pedi.12325
language
English
LU publication?
yes
id
712aa648-120c-4f04-9725-5ab9d7885df3
date added to LUP
2016-08-02 09:49:40
date last changed
2017-01-01 08:31:18
@article{712aa648-120c-4f04-9725-5ab9d7885df3,
  abstract     = {<p>Background: The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. Objectives: Ongoing prediction and prevention studies in Skåne, Sweden are described. Methods: During September 2000 to August 2004, 35 000 children were screened at birth for genetic type 1 diabetes risk in the Diabetes Prediction in Skåne Study (DiPiS). In August 2004, the screening continued within the Enviromnental Determinants of Diabetes in the Young study (TEDDY). In the clinical trial Diabetes Prevention – Immune Tolerance (DiAPREV-IT), children with multiple islet autoimmunity have been included to investigate if immune tolerance with Alum-formulated GAD65 may prevent further beta-cell loss. Results: In DiPiS and TEDDY, a large number of children are followed in order to find the factors that trigger the autoimmune process leading to type 1 diabetes. Children followed in the studies develop diabetes at an early stage of disease, with few symptoms and a low frequency of diabetes ketoacidosis. DiAPREV-IT is still blinded and results will be available in December 2016. Conclusion: Large prospective studies will be needed to understand the complex process leading to type 1 diabetes. Secondary prevention may be possible in children with islet autoimmunity, but the studies are complicated by the variability of glucose metabolism and beta-cell loss.</p>},
  author       = {Elding Larsson, Helena},
  issn         = {1399-543X},
  keyword      = {pediatric diabetes,prevention,Sweden,type 1 diabetes mellitus},
  language     = {eng},
  month        = {07},
  number       = {S22},
  pages        = {73--77},
  publisher    = {Wiley-Blackwell},
  series       = {Pediatric Diabetes},
  title        = {A Swedish approach to the prevention of type 1 diabetes},
  url          = {http://dx.doi.org/10.1111/pedi.12325},
  volume       = {17},
  year         = {2016},
}