Proliferative synovitis in rabbit knee joints induced by antigen and preformed immune complexes
(1985) In Scandinavian Journal of Rheumatology 14(3). p.239-251- Abstract
- Knee joints of non-immunized rabbits were repeatedly injected with bovine serum albumin (BSA) and preformed BSA-anti-BSA immune complexes which had differing precipitation profiles and abilities to activate complement. Ten days after the last of six injections the antibody and lymphoproliferative responses to BSA were analysed and correlated to the degree of arthritis. Joint swelling, increased numbers of joint fluid leukocytes and morphological changes typical of proliferative synovitis were found only in those rabbits injected with a large dose of antigen or with immune complexes prepared in antigen excess of poor precipitation and complement-activating properties in vitro. The degree of arthritis correlated with the development of... (More)
- Knee joints of non-immunized rabbits were repeatedly injected with bovine serum albumin (BSA) and preformed BSA-anti-BSA immune complexes which had differing precipitation profiles and abilities to activate complement. Ten days after the last of six injections the antibody and lymphoproliferative responses to BSA were analysed and correlated to the degree of arthritis. Joint swelling, increased numbers of joint fluid leukocytes and morphological changes typical of proliferative synovitis were found only in those rabbits injected with a large dose of antigen or with immune complexes prepared in antigen excess of poor precipitation and complement-activating properties in vitro. The degree of arthritis correlated with the development of humoral and lymphoproliferative immune responses to BSA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103366
- author
- Thomsen, P ; Bjursten, Lars Magnus LU ; Ahlstedt, S ; Bagge, U and Ericson, L E
- publishing date
- 1985
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Rheumatology
- volume
- 14
- issue
- 3
- pages
- 239 - 251
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:4048873
- scopus:0021934754
- ISSN
- 1502-7732
- DOI
- 10.3109/03009748509100401
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910)
- id
- 7188babf-efc4-4674-85ac-7db2d4e9d464 (old id 1103366)
- date added to LUP
- 2016-04-01 11:36:01
- date last changed
- 2021-01-03 04:30:55
@article{7188babf-efc4-4674-85ac-7db2d4e9d464,
abstract = {{Knee joints of non-immunized rabbits were repeatedly injected with bovine serum albumin (BSA) and preformed BSA-anti-BSA immune complexes which had differing precipitation profiles and abilities to activate complement. Ten days after the last of six injections the antibody and lymphoproliferative responses to BSA were analysed and correlated to the degree of arthritis. Joint swelling, increased numbers of joint fluid leukocytes and morphological changes typical of proliferative synovitis were found only in those rabbits injected with a large dose of antigen or with immune complexes prepared in antigen excess of poor precipitation and complement-activating properties in vitro. The degree of arthritis correlated with the development of humoral and lymphoproliferative immune responses to BSA.}},
author = {{Thomsen, P and Bjursten, Lars Magnus and Ahlstedt, S and Bagge, U and Ericson, L E}},
issn = {{1502-7732}},
language = {{eng}},
number = {{3}},
pages = {{239--251}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Rheumatology}},
title = {{Proliferative synovitis in rabbit knee joints induced by antigen and preformed immune complexes}},
url = {{http://dx.doi.org/10.3109/03009748509100401}},
doi = {{10.3109/03009748509100401}},
volume = {{14}},
year = {{1985}},
}