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Tonsillectomy associated with an increased risk of autoimmune diseases : A national cohort study

Ji, Jianguang LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2016) In Journal of Autoimmunity 72. p.1-7
Abstract

Background Tonsillectomy is a common surgical procedure. Recent evidence suggests that tonsils play an important role in our immune system. We thus hypothesize that individuals with tonsillectomy may face an increased incidence of autoimmune diseases in their later life. Methods All individuals that had a tonsillectomy in Sweden between 1997 and 2012 were identified from the Swedish Hospital Discharge and Outpatient Register, and were followed until the diagnosis of a set of autoimmune diseases. Standardized incidence ratios (SIRs) were used to calculate the risk of autoimmune diseases as compared to the general population. Results A total of 179,875 individuals received a tonsillectomy in Sweden and 5357 of them were subsequently... (More)

Background Tonsillectomy is a common surgical procedure. Recent evidence suggests that tonsils play an important role in our immune system. We thus hypothesize that individuals with tonsillectomy may face an increased incidence of autoimmune diseases in their later life. Methods All individuals that had a tonsillectomy in Sweden between 1997 and 2012 were identified from the Swedish Hospital Discharge and Outpatient Register, and were followed until the diagnosis of a set of autoimmune diseases. Standardized incidence ratios (SIRs) were used to calculate the risk of autoimmune diseases as compared to the general population. Results A total of 179,875 individuals received a tonsillectomy in Sweden and 5357 of them were subsequently diagnosed with autoimmune diseases, giving an overall SIR of 1.34 (95%CI 1.30–1.37). For specific autoimmune diseases, 16 of them showed a significantly increased SIR, ranging between 1.21 and 2.97. The increased incidence was largely consistent irrespective of gender, age at operation, and underlying indications of tonsillectomy. Conclusions The incidence of a group of autoimmune diseases was higher in individuals operated with a tonsillectomy. Immune dysfunction due to tonsillectomy may partly explain the observed association. However, the underlying mechanisms need to be explored in future studies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmune diseases, Cohort study, Tonsillectomy
in
Journal of Autoimmunity
volume
72
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:84991363534
  • wos:000381649400001
ISSN
0896-8411
DOI
10.1016/j.jaut.2016.06.007
language
English
LU publication?
yes
id
71ea6e39-252c-4713-a465-d00a6c28300a
date added to LUP
2016-11-04 11:37:13
date last changed
2017-10-08 04:54:14
@article{71ea6e39-252c-4713-a465-d00a6c28300a,
  abstract     = {<p>Background Tonsillectomy is a common surgical procedure. Recent evidence suggests that tonsils play an important role in our immune system. We thus hypothesize that individuals with tonsillectomy may face an increased incidence of autoimmune diseases in their later life. Methods All individuals that had a tonsillectomy in Sweden between 1997 and 2012 were identified from the Swedish Hospital Discharge and Outpatient Register, and were followed until the diagnosis of a set of autoimmune diseases. Standardized incidence ratios (SIRs) were used to calculate the risk of autoimmune diseases as compared to the general population. Results A total of 179,875 individuals received a tonsillectomy in Sweden and 5357 of them were subsequently diagnosed with autoimmune diseases, giving an overall SIR of 1.34 (95%CI 1.30–1.37). For specific autoimmune diseases, 16 of them showed a significantly increased SIR, ranging between 1.21 and 2.97. The increased incidence was largely consistent irrespective of gender, age at operation, and underlying indications of tonsillectomy. Conclusions The incidence of a group of autoimmune diseases was higher in individuals operated with a tonsillectomy. Immune dysfunction due to tonsillectomy may partly explain the observed association. However, the underlying mechanisms need to be explored in future studies.</p>},
  author       = {Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0896-8411},
  keyword      = {Autoimmune diseases,Cohort study,Tonsillectomy},
  language     = {eng},
  month        = {08},
  pages        = {1--7},
  publisher    = {Elsevier},
  series       = {Journal of Autoimmunity},
  title        = {Tonsillectomy associated with an increased risk of autoimmune diseases : A national cohort study},
  url          = {http://dx.doi.org/10.1016/j.jaut.2016.06.007},
  volume       = {72},
  year         = {2016},
}