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Gerronemins A-F, cytotoxic biscatechols from a Gerronema species

Silberborth, S ; Stumpf, A ; Erkel, G ; Anke, T and Sterner, Olov LU (2002) In Phytochemistry 59(6). p.643-648
Abstract
The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytotoxic activity, biscatechols, Gerronema, gerronemins A-F
in
Phytochemistry
volume
59
issue
6
pages
643 - 648
publisher
Elsevier
external identifiers
  • pmid:11867096
  • wos:000174870800007
  • scopus:0037085613
ISSN
0031-9422
DOI
10.1016/S0031-9422(02)00013-4
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
720d11f7-d7ee-44fd-8843-f097ba3fc19e (old id 340550)
date added to LUP
2016-04-01 16:44:48
date last changed
2022-02-27 23:22:32
@article{720d11f7-d7ee-44fd-8843-f097ba3fc19e,
  abstract     = {{The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.}},
  author       = {{Silberborth, S and Stumpf, A and Erkel, G and Anke, T and Sterner, Olov}},
  issn         = {{0031-9422}},
  keywords     = {{cytotoxic activity; biscatechols; Gerronema; gerronemins A-F}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{643--648}},
  publisher    = {{Elsevier}},
  series       = {{Phytochemistry}},
  title        = {{Gerronemins A-F, cytotoxic biscatechols from a Gerronema species}},
  url          = {{http://dx.doi.org/10.1016/S0031-9422(02)00013-4}},
  doi          = {{10.1016/S0031-9422(02)00013-4}},
  volume       = {{59}},
  year         = {{2002}},
}