Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk
(2012) In Nature Genetics 44(11). p.1182-1184- Abstract
- We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3283699
- author
- Orr, Nick
; Lemnrau, Alina
; Cooke, Rosie
; Fletcher, Olivia
; Tomczyk, Katarzyna
; Jones, Michael
; Johnson, Nichola
; Lord, Christopher J.
; Mitsopoulos, Costas
; Zvelebil, Marketa
; McDade, Simon S.
; Buck, Gemma
; Blancher, Christine
; Trainer, Alison H.
; James, Paul A.
; Bojesen, Stig E.
; Bokmand, Susanne
; Nevanlinna, Heli
; Mattson, Johanna
; Friedman, Eitan
; Laitman, Yael
; Palli, Domenico
; Masala, Giovanna
; Zanna, Ines
; Ottini, Laura
; Giannini, Giuseppe
; Hollestelle, Antoinette
; van den Ouweland, Ans M. W.
; Novakovic, Srdjan
; Krajc, Mateja
; Gago-Dominguez, Manuela
; Castelao, Jose Esteban
; Olsson, Håkan
LU
; Hedenfalk, Ingrid
LU
; Easton, Douglas F.
; Pharoah, Paul D. P.
; Dunning, Alison M.
; Bishop, D. Timothy
; Neuhausen, Susan L.
; Steele, Linda
; Houlston, Richard S.
; Garcia-Closas, Montserrat
; Ashworth, Alan
and Swerdlow, Anthony J.
(Less) - organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Genetics
- volume
- 44
- issue
- 11
- pages
- 1182 - 1184
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000310495800006
- scopus:84868207237
- pmid:23001122
- ISSN
- 1546-1718
- DOI
- 10.1038/ng.2417
- language
- English
- LU publication?
- yes
- id
- 72773106-a12e-4cbb-8a5e-550403775f69 (old id 3283699)
- date added to LUP
- 2016-04-01 14:48:45
- date last changed
- 2022-04-22 05:19:26
@article{72773106-a12e-4cbb-8a5e-550403775f69,
abstract = {{We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).}},
author = {{Orr, Nick and Lemnrau, Alina and Cooke, Rosie and Fletcher, Olivia and Tomczyk, Katarzyna and Jones, Michael and Johnson, Nichola and Lord, Christopher J. and Mitsopoulos, Costas and Zvelebil, Marketa and McDade, Simon S. and Buck, Gemma and Blancher, Christine and Trainer, Alison H. and James, Paul A. and Bojesen, Stig E. and Bokmand, Susanne and Nevanlinna, Heli and Mattson, Johanna and Friedman, Eitan and Laitman, Yael and Palli, Domenico and Masala, Giovanna and Zanna, Ines and Ottini, Laura and Giannini, Giuseppe and Hollestelle, Antoinette and van den Ouweland, Ans M. W. and Novakovic, Srdjan and Krajc, Mateja and Gago-Dominguez, Manuela and Castelao, Jose Esteban and Olsson, Håkan and Hedenfalk, Ingrid and Easton, Douglas F. and Pharoah, Paul D. P. and Dunning, Alison M. and Bishop, D. Timothy and Neuhausen, Susan L. and Steele, Linda and Houlston, Richard S. and Garcia-Closas, Montserrat and Ashworth, Alan and Swerdlow, Anthony J.}},
issn = {{1546-1718}},
language = {{eng}},
number = {{11}},
pages = {{1182--1184}},
publisher = {{Nature Publishing Group}},
series = {{Nature Genetics}},
title = {{Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk}},
url = {{http://dx.doi.org/10.1038/ng.2417}},
doi = {{10.1038/ng.2417}},
volume = {{44}},
year = {{2012}},
}