Neuropsychiatric and behavioral profiles of 2 adults with williams syndrome: response to antidepressant intake.
Urgeles, Diego ; Alonso, Victoria and Ramos Moreno, Tania LU
(2013)
In The primary care companion for CNS disorders
15(4).
- Abstract
- Background: Individuals with Williams syndrome, a rare genetic disorder, are characterized by specific medical, cognitive, and behavioral phenotypes and often have high anxiety levels as well as phobia. Studies of the psychiatric phenotype in adults affected by Williams syndrome or literature on the management of their mental pathologies are lacking. Method: In this article, we report the neuropsychiatric profile of 2 adult patients with Williams syndrome who also have generalized anxiety disorder and depressive symptoms (DSM-IV-TR criteria), along with their anxiety profiles and the strategies that were adopted for pharmacologic intervention. Results: Neuropsychiatric profiles revealed a prefrontal cortex affliction that includes an... (More)
- Background: Individuals with Williams syndrome, a rare genetic disorder, are characterized by specific medical, cognitive, and behavioral phenotypes and often have high anxiety levels as well as phobia. Studies of the psychiatric phenotype in adults affected by Williams syndrome or literature on the management of their mental pathologies are lacking. Method: In this article, we report the neuropsychiatric profile of 2 adult patients with Williams syndrome who also have generalized anxiety disorder and depressive symptoms (DSM-IV-TR criteria), along with their anxiety profiles and the strategies that were adopted for pharmacologic intervention. Results: Neuropsychiatric profiles revealed a prefrontal cortex affliction that includes an alteration in executive functions. The patients had high scores for trait-anxiety and responded to treatment with a low-potency antipsychotic. A selective serotonin reuptake inhibitor (SSRI) was coadministered with the antipsychotic to alleviate the depressive symptoms. The treatment led to an improvement in self-control, mental concentration, and social skills, as well as decreased irritability and aggressiveness and stabilization of mood. Conclusions: The combination of SSRIs and low doses of low-potency antipsychotics seems to be the most suitable medication to treat generalized anxiety disorder and related disorders in individuals with Williams syndrome. Manic reactions and increase in anxiety must be closely monitored during treatment. Control of anxiety and sleep should be a priority in these patients, even as a preventative measure. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4292011
- author
- Urgeles, Diego
; Alonso, Victoria
and Ramos Moreno, Tania
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The primary care companion for CNS disorders
- volume
- 15
- issue
- 4
- publisher
- Physicians Postgraduate Press
- external identifiers
-
- pmid:24392262
- scopus:84884277791
- ISSN
- 2155-7772
- DOI
- 10.4088/PCC.13m01504
- language
- English
- LU publication?
- yes
- id
- 72963d63-c740-461f-a4a9-6064f85f0fc2 (old id 4292011)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24392262?dopt=Abstract
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869614/
- date added to LUP
- 2016-04-01 11:13:34
- date last changed
- 2022-02-18 01:00:43
@article{72963d63-c740-461f-a4a9-6064f85f0fc2,
abstract = {{Background: Individuals with Williams syndrome, a rare genetic disorder, are characterized by specific medical, cognitive, and behavioral phenotypes and often have high anxiety levels as well as phobia. Studies of the psychiatric phenotype in adults affected by Williams syndrome or literature on the management of their mental pathologies are lacking. Method: In this article, we report the neuropsychiatric profile of 2 adult patients with Williams syndrome who also have generalized anxiety disorder and depressive symptoms (DSM-IV-TR criteria), along with their anxiety profiles and the strategies that were adopted for pharmacologic intervention. Results: Neuropsychiatric profiles revealed a prefrontal cortex affliction that includes an alteration in executive functions. The patients had high scores for trait-anxiety and responded to treatment with a low-potency antipsychotic. A selective serotonin reuptake inhibitor (SSRI) was coadministered with the antipsychotic to alleviate the depressive symptoms. The treatment led to an improvement in self-control, mental concentration, and social skills, as well as decreased irritability and aggressiveness and stabilization of mood. Conclusions: The combination of SSRIs and low doses of low-potency antipsychotics seems to be the most suitable medication to treat generalized anxiety disorder and related disorders in individuals with Williams syndrome. Manic reactions and increase in anxiety must be closely monitored during treatment. Control of anxiety and sleep should be a priority in these patients, even as a preventative measure.}},
author = {{Urgeles, Diego and Alonso, Victoria and Ramos Moreno, Tania}},
issn = {{2155-7772}},
language = {{eng}},
number = {{4}},
publisher = {{Physicians Postgraduate Press}},
series = {{The primary care companion for CNS disorders}},
title = {{Neuropsychiatric and behavioral profiles of 2 adults with williams syndrome: response to antidepressant intake.}},
url = {{http://dx.doi.org/10.4088/PCC.13m01504}},
doi = {{10.4088/PCC.13m01504}},
volume = {{15}},
year = {{2013}},
}