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Exposure to source-specific air pollution in residential areas and its association with dementia incidence : a cohort study in Northern Sweden

Oudin, Anna LU ; Raza, Wasif ; Flanagan, Erin LU orcid ; Segersson, David ; Jalava, Pasi ; Kanninen, Katja M. ; Rönkkö, Topi ; Giugno, Rosalba ; Sandström, Thomas and Muala, Ala , et al. (2024) In Scientific Reports 14(1).
Abstract

The aim of this study was to investigate the relationship between source-specific ambient particulate air pollution concentrations and the incidence of dementia. The study encompassed 70,057 participants from the Västerbotten intervention program cohort in Northern Sweden with a median age of 40 years at baseline. High-resolution dispersion models were employed to estimate source-specific particulate matter (PM) concentrations, such as PM10 and PM2.5 from traffic, exhaust, and biomass (mainly wood) burning, at the residential addresses of each participant. Cox regression models, adjusted for potential confounding factors, were used for the assessment. Over 884,847 person-years of follow-up, 409 incident dementia... (More)

The aim of this study was to investigate the relationship between source-specific ambient particulate air pollution concentrations and the incidence of dementia. The study encompassed 70,057 participants from the Västerbotten intervention program cohort in Northern Sweden with a median age of 40 years at baseline. High-resolution dispersion models were employed to estimate source-specific particulate matter (PM) concentrations, such as PM10 and PM2.5 from traffic, exhaust, and biomass (mainly wood) burning, at the residential addresses of each participant. Cox regression models, adjusted for potential confounding factors, were used for the assessment. Over 884,847 person-years of follow-up, 409 incident dementia cases, identified through national registers, were observed. The study population’s average exposure to annual mean total PM10 and PM2.5 lag 1–5 years was 9.50 µg/m3 and 5.61 µg/m3, respectively. Increased risks were identified for PM10-Traffic (35% [95% CI 0–82%]) and PM2.5-Exhaust (33% [95% CI − 2 to 79%]) in the second exposure tertile for lag 1–5 years, although no such risks were observed in the third tertile. Interestingly, a negative association was observed between PM2.5-Wood burning and the risk of dementia. In summary, this register-based study did not conclusively establish a strong association between air pollution exposure and the incidence of dementia. While some evidence indicated elevated risks for PM10-Traffic and PM2.5-Exhaust, and conversely, a negative association for PM2.5-Wood burning, no clear exposure–response relationships were evident.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
14
issue
1
article number
15521
publisher
Nature Publishing Group
external identifiers
  • pmid:38969679
  • scopus:85197559192
ISSN
2045-2322
DOI
10.1038/s41598-024-66166-y
language
English
LU publication?
yes
id
72ac9963-e9e5-4823-8cf6-5e3bee98829e
date added to LUP
2024-08-26 13:06:18
date last changed
2024-09-09 14:20:23
@article{72ac9963-e9e5-4823-8cf6-5e3bee98829e,
  abstract     = {{<p>The aim of this study was to investigate the relationship between source-specific ambient particulate air pollution concentrations and the incidence of dementia. The study encompassed 70,057 participants from the Västerbotten intervention program cohort in Northern Sweden with a median age of 40 years at baseline. High-resolution dispersion models were employed to estimate source-specific particulate matter (PM) concentrations, such as PM<sub>10</sub> and PM<sub>2.5</sub> from traffic, exhaust, and biomass (mainly wood) burning, at the residential addresses of each participant. Cox regression models, adjusted for potential confounding factors, were used for the assessment. Over 884,847 person-years of follow-up, 409 incident dementia cases, identified through national registers, were observed. The study population’s average exposure to annual mean total PM<sub>10</sub> and PM<sub>2.5</sub> lag 1–5 years was 9.50 µg/m<sup>3</sup> and 5.61 µg/m<sup>3</sup>, respectively. Increased risks were identified for PM<sub>10</sub>-Traffic (35% [95% CI 0–82%]) and PM<sub>2.5</sub>-Exhaust (33% [95% CI − 2 to 79%]) in the second exposure tertile for lag 1–5 years, although no such risks were observed in the third tertile. Interestingly, a negative association was observed between PM<sub>2.5</sub>-Wood burning and the risk of dementia. In summary, this register-based study did not conclusively establish a strong association between air pollution exposure and the incidence of dementia. While some evidence indicated elevated risks for PM<sub>10</sub>-Traffic and PM<sub>2.5</sub>-Exhaust, and conversely, a negative association for PM<sub>2.5</sub>-Wood burning, no clear exposure–response relationships were evident.</p>}},
  author       = {{Oudin, Anna and Raza, Wasif and Flanagan, Erin and Segersson, David and Jalava, Pasi and Kanninen, Katja M. and Rönkkö, Topi and Giugno, Rosalba and Sandström, Thomas and Muala, Ala and Topinka, Jan and Sommar, Johan}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Exposure to source-specific air pollution in residential areas and its association with dementia incidence : a cohort study in Northern Sweden}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-66166-y}},
  doi          = {{10.1038/s41598-024-66166-y}},
  volume       = {{14}},
  year         = {{2024}},
}