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PDGF family function and prognostic value in tumor biology

Bartoschek, Michael LU and Pietras, Kristian LU (2018) In Biochemical and Biophysical Research Communications 503(2). p.984-990
Abstract

The development and progression of a tumor depends on the close interaction of malignant cells and the supportive and suppressive tumor microenvironment. Paracrine signaling enables tumor cells to shape the surrounding tissue in order to decrease recognition by the immune system, attract blood vessels to fuel growth, change metabolic programs, and induce wound healing programs. In this study, we investigate the role of the platelet-derived growth factor (PDGF) family members PDGFA, PDGFB, PDGFC and PDGFD and their cognate tyrosine kinase receptors PDGFRA and PDGFRB, using publicly available data from The Cancer Genome Atlas and the Human Protein Atlas. Large scale analysis of expression correlation in RNA sequencing data from 7616... (More)

The development and progression of a tumor depends on the close interaction of malignant cells and the supportive and suppressive tumor microenvironment. Paracrine signaling enables tumor cells to shape the surrounding tissue in order to decrease recognition by the immune system, attract blood vessels to fuel growth, change metabolic programs, and induce wound healing programs. In this study, we investigate the role of the platelet-derived growth factor (PDGF) family members PDGFA, PDGFB, PDGFC and PDGFD and their cognate tyrosine kinase receptors PDGFRA and PDGFRB, using publicly available data from The Cancer Genome Atlas and the Human Protein Atlas. Large scale analysis of expression correlation in RNA sequencing data from 7616 samples derived from 16 tumor types, revealed conserved functional programs in PDGF signaling in the majority of solid tumor types. Besides the well-known effects of PDGF signaling in mesenchymal cells, our analyses revealed a potential role of PDGF signaling in the composition of the immune microenvironment. We furthermore derived gene signatures with increased prognostic value for each PDGF family member. This study emphasizes the potential to impinge on specific paracrine signaling events to interfere with the crosstalk between malignant cells and their microenvironment.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cancer, Expression analysis, Platelet-derived growth factor
in
Biochemical and Biophysical Research Communications
volume
503
issue
2
pages
984 - 990
publisher
Elsevier
external identifiers
  • scopus:85048888050
ISSN
0006-291X
DOI
10.1016/j.bbrc.2018.06.106
language
English
LU publication?
yes
id
72b5a96a-b3e6-4e7f-a308-b38a6544c71b
date added to LUP
2018-07-04 15:25:25
date last changed
2019-01-14 17:43:53
@article{72b5a96a-b3e6-4e7f-a308-b38a6544c71b,
  abstract     = {<p>The development and progression of a tumor depends on the close interaction of malignant cells and the supportive and suppressive tumor microenvironment. Paracrine signaling enables tumor cells to shape the surrounding tissue in order to decrease recognition by the immune system, attract blood vessels to fuel growth, change metabolic programs, and induce wound healing programs. In this study, we investigate the role of the platelet-derived growth factor (PDGF) family members PDGFA, PDGFB, PDGFC and PDGFD and their cognate tyrosine kinase receptors PDGFRA and PDGFRB, using publicly available data from The Cancer Genome Atlas and the Human Protein Atlas. Large scale analysis of expression correlation in RNA sequencing data from 7616 samples derived from 16 tumor types, revealed conserved functional programs in PDGF signaling in the majority of solid tumor types. Besides the well-known effects of PDGF signaling in mesenchymal cells, our analyses revealed a potential role of PDGF signaling in the composition of the immune microenvironment. We furthermore derived gene signatures with increased prognostic value for each PDGF family member. This study emphasizes the potential to impinge on specific paracrine signaling events to interfere with the crosstalk between malignant cells and their microenvironment.</p>},
  author       = {Bartoschek, Michael and Pietras, Kristian},
  issn         = {0006-291X},
  keyword      = {Cancer,Expression analysis,Platelet-derived growth factor},
  language     = {eng},
  month        = {06},
  number       = {2},
  pages        = {984--990},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {PDGF family function and prognostic value in tumor biology},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2018.06.106},
  volume       = {503},
  year         = {2018},
}