Postural orthostatic tachycardia syndrome (POTS) : Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting - Part 2
(2021) In Autonomic Neuroscience: Basic & Clinical 235.- Abstract
The National Institutes of Health hosted a workshop in 2019 to build consensus around the current state of understanding of the pathophysiology of postural orthostatic tachycardia syndrome (POTS) and to identify knowledge gaps that must be addressed to enhance clinical care of POTS patients through research. This second (of two) articles summarizes current knowledge gaps, and outlines the clinical and research priorities for POTS. POTS is a complex, multi-system, chronic disorder of the autonomic nervous system characterized by orthostatic intolerance and orthostatic tachycardia without hypotension. Patients often experience a host of other related disabling symptoms. The functional and economic impacts of this disorder are significant.... (More)
The National Institutes of Health hosted a workshop in 2019 to build consensus around the current state of understanding of the pathophysiology of postural orthostatic tachycardia syndrome (POTS) and to identify knowledge gaps that must be addressed to enhance clinical care of POTS patients through research. This second (of two) articles summarizes current knowledge gaps, and outlines the clinical and research priorities for POTS. POTS is a complex, multi-system, chronic disorder of the autonomic nervous system characterized by orthostatic intolerance and orthostatic tachycardia without hypotension. Patients often experience a host of other related disabling symptoms. The functional and economic impacts of this disorder are significant. The pathophysiology remains incompletely understood. Beyond the significant gaps in understanding the disorder itself, there is a paucity of evidence to guide treatment which can contribute to suboptimal care for this patient population. The vast majority of physicians have minimal to no familiarity or training in the assessment and management of POTS. Funding for POTS research remains very low relative to the size of the patient population and impact of the syndrome. In addition to efforts to improve awareness and physician education, an investment in research infrastructure including the development of standardized disease-specific evaluation tools and outcome measures is needed to facilitate effective collaborative research. A national POTS research consortium could facilitate well-controlled multidisciplinary clinical research studies and therapeutic trials. These priorities will require a substantial increase in the number of research investigators and the amount of research funding in this area.
(Less)
- author
- Raj, Satish R
; Bourne, Kate M
; Stiles, Lauren E
; Miglis, Mitchell G
; Cortez, Melissa M
; Miller, Amanda J
; Freeman, Roy
; Biaggioni, Italo
; Rowe, Peter C
; Sheldon, Robert S
; Shibao, Cyndya A
; Diedrich, Andre
; Systrom, David M
; Cook, Glen A
; Doherty, Taylor A
; Abdallah, Hasan I
; Grubb, Blair P
; Fedorowski, Artur
LU
; Stewart, Julian M
; Arnold, Amy C
; Pace, Laura A
; Axelsson, Jonas
LU
; Boris, Jeffrey R
; Moak, Jeffrey P
; Goodman, Brent P
; Chémali, Kamal R
; Chung, Tae H
; Goldstein, David S
; Darbari, Anil
and Vernino, Steven
(Less) - organization
- publishing date
- 2021-06-30
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Expert Consensus, Pathophysiology, Postural orthostatic tachycardia syndrome, Treatment, Workshop
- in
- Autonomic Neuroscience: Basic & Clinical
- volume
- 235
- article number
- 102836
- publisher
- Elsevier
- external identifiers
-
- pmid:34246578
- scopus:85110059679
- pmid:34246578
- ISSN
- 1872-7484
- DOI
- 10.1016/j.autneu.2021.102836
- language
- English
- LU publication?
- yes
- id
- 72d87dd1-a0eb-449d-b928-12e50d8bd920
- date added to LUP
- 2021-07-16 10:52:00
- date last changed
- 2024-06-15 13:34:13
@article{72d87dd1-a0eb-449d-b928-12e50d8bd920,
abstract = {{<p>The National Institutes of Health hosted a workshop in 2019 to build consensus around the current state of understanding of the pathophysiology of postural orthostatic tachycardia syndrome (POTS) and to identify knowledge gaps that must be addressed to enhance clinical care of POTS patients through research. This second (of two) articles summarizes current knowledge gaps, and outlines the clinical and research priorities for POTS. POTS is a complex, multi-system, chronic disorder of the autonomic nervous system characterized by orthostatic intolerance and orthostatic tachycardia without hypotension. Patients often experience a host of other related disabling symptoms. The functional and economic impacts of this disorder are significant. The pathophysiology remains incompletely understood. Beyond the significant gaps in understanding the disorder itself, there is a paucity of evidence to guide treatment which can contribute to suboptimal care for this patient population. The vast majority of physicians have minimal to no familiarity or training in the assessment and management of POTS. Funding for POTS research remains very low relative to the size of the patient population and impact of the syndrome. In addition to efforts to improve awareness and physician education, an investment in research infrastructure including the development of standardized disease-specific evaluation tools and outcome measures is needed to facilitate effective collaborative research. A national POTS research consortium could facilitate well-controlled multidisciplinary clinical research studies and therapeutic trials. These priorities will require a substantial increase in the number of research investigators and the amount of research funding in this area.</p>}},
author = {{Raj, Satish R and Bourne, Kate M and Stiles, Lauren E and Miglis, Mitchell G and Cortez, Melissa M and Miller, Amanda J and Freeman, Roy and Biaggioni, Italo and Rowe, Peter C and Sheldon, Robert S and Shibao, Cyndya A and Diedrich, Andre and Systrom, David M and Cook, Glen A and Doherty, Taylor A and Abdallah, Hasan I and Grubb, Blair P and Fedorowski, Artur and Stewart, Julian M and Arnold, Amy C and Pace, Laura A and Axelsson, Jonas and Boris, Jeffrey R and Moak, Jeffrey P and Goodman, Brent P and Chémali, Kamal R and Chung, Tae H and Goldstein, David S and Darbari, Anil and Vernino, Steven}},
issn = {{1872-7484}},
keywords = {{Expert Consensus; Pathophysiology; Postural orthostatic tachycardia syndrome; Treatment; Workshop}},
language = {{eng}},
month = {{06}},
publisher = {{Elsevier}},
series = {{Autonomic Neuroscience: Basic & Clinical}},
title = {{Postural orthostatic tachycardia syndrome (POTS) : Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting - Part 2}},
url = {{http://dx.doi.org/10.1016/j.autneu.2021.102836}},
doi = {{10.1016/j.autneu.2021.102836}},
volume = {{235}},
year = {{2021}},
}