Can resting-state functional MRI serve as a complement to task-based mapping of sensorimotor function? A test-retest reliability study in healthy volunteers.
Mannfolk, Peter LU ; Nilsson, Markus LU ; Hansson, Henrik ; Ståhlberg, Freddy LU ; Fransson, Peter ; Weibull, Andreas LU ; Svensson, Jonas LU ; Wirestam, Ronnie LU
and Olsrud, Johan
LU
(2011)
In Journal of Magnetic Resonance Imaging
34.
p.511-517
- Abstract
- PURPOSE: To investigate if resting-state functional MRI (fMRI) reliably can serve as a complement to task-based fMRI for presurgical mapping of the sensorimotor cortex. MATERIALS AND METHODS: Functional data were obtained in 10 healthy volunteers using a 3 Tesla MRI system. Each subject performed five bilateral finger tapping experiments interleaved with five resting-state experiments. Following preprocessing, data from eight volunteers were further analyzed with the general linear model (finger tapping data) and independent component analysis (rest data). Test-retest reliability estimates (hit rate and false alarm rate) for resting-state fMRI activation of the sensorimotor network were compared with the reliability estimates for... (More)
- PURPOSE: To investigate if resting-state functional MRI (fMRI) reliably can serve as a complement to task-based fMRI for presurgical mapping of the sensorimotor cortex. MATERIALS AND METHODS: Functional data were obtained in 10 healthy volunteers using a 3 Tesla MRI system. Each subject performed five bilateral finger tapping experiments interleaved with five resting-state experiments. Following preprocessing, data from eight volunteers were further analyzed with the general linear model (finger tapping data) and independent component analysis (rest data). Test-retest reliability estimates (hit rate and false alarm rate) for resting-state fMRI activation of the sensorimotor network were compared with the reliability estimates for task-evoked activation of the sensorimotor cortex. The reliability estimates constituted a receiver operating characteristics curve from which the area under the curve (AUC) was calculated. Statistical testing was performed to compare the two groups with respect to reliability. RESULTS: The AUC was generally higher for the task experiments, although median AUC was not significantly different on a group level. Also, the two groups showed comparable levels of within-group variance. CONCLUSION: Test-retest reliability was comparable between resting-state measurements and task-based fMRI, suggesting that presurgical mapping of functional networks can be a supplement to task-based fMRI in cases where patient status excludes task-based fMRI. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2058619
- author
- Mannfolk, Peter
LU
; Nilsson, Markus
LU
; Hansson, Henrik
; Ståhlberg, Freddy
LU
; Fransson, Peter
; Weibull, Andreas
LU
; Svensson, Jonas
LU
; Wirestam, Ronnie
LU
and Olsrud, Johan
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Magnetic Resonance Imaging
- volume
- 34
- pages
- 511 - 517
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000294442900004
- pmid:21761469
- scopus:80051917965
- ISSN
- 1522-2586
- DOI
- 10.1002/jmri.22654
- language
- English
- LU publication?
- yes
- id
- 72f2f0f7-3695-464b-9381-d3a797d136f2 (old id 2058619)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21761469?dopt=Abstract
- date added to LUP
- 2016-04-04 08:33:17
- date last changed
- 2022-04-15 20:24:38
@article{72f2f0f7-3695-464b-9381-d3a797d136f2,
abstract = {{PURPOSE: To investigate if resting-state functional MRI (fMRI) reliably can serve as a complement to task-based fMRI for presurgical mapping of the sensorimotor cortex. MATERIALS AND METHODS: Functional data were obtained in 10 healthy volunteers using a 3 Tesla MRI system. Each subject performed five bilateral finger tapping experiments interleaved with five resting-state experiments. Following preprocessing, data from eight volunteers were further analyzed with the general linear model (finger tapping data) and independent component analysis (rest data). Test-retest reliability estimates (hit rate and false alarm rate) for resting-state fMRI activation of the sensorimotor network were compared with the reliability estimates for task-evoked activation of the sensorimotor cortex. The reliability estimates constituted a receiver operating characteristics curve from which the area under the curve (AUC) was calculated. Statistical testing was performed to compare the two groups with respect to reliability. RESULTS: The AUC was generally higher for the task experiments, although median AUC was not significantly different on a group level. Also, the two groups showed comparable levels of within-group variance. CONCLUSION: Test-retest reliability was comparable between resting-state measurements and task-based fMRI, suggesting that presurgical mapping of functional networks can be a supplement to task-based fMRI in cases where patient status excludes task-based fMRI. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.}},
author = {{Mannfolk, Peter and Nilsson, Markus and Hansson, Henrik and Ståhlberg, Freddy and Fransson, Peter and Weibull, Andreas and Svensson, Jonas and Wirestam, Ronnie and Olsrud, Johan}},
issn = {{1522-2586}},
language = {{eng}},
pages = {{511--517}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Magnetic Resonance Imaging}},
title = {{Can resting-state functional MRI serve as a complement to task-based mapping of sensorimotor function? A test-retest reliability study in healthy volunteers.}},
url = {{http://dx.doi.org/10.1002/jmri.22654}},
doi = {{10.1002/jmri.22654}},
volume = {{34}},
year = {{2011}},
}