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Other cancers in lung cancer families are overwhelmingly smoking-related cancers

Yu, Hongyao LU ; Frank, Christoph LU ; Hemminki, Akseli; Sundquist, Kristina LU and Hemminki, Kari LU (2017) In ERS Monograph 3(2).
Abstract

Familial risks of lung cancer are well-established, but whether lung cancer clusters with other discordant cancers is less certain, particularly beyond smoking-related sites, which may provide evidence on genetic contributions to lung cancer aetiology. We used a novel approach to search for familial associations in the Swedish Family-Cancer Database. This involved assessment of familial relative risk for cancer X in families with increasing numbers of lung cancer patients and, conversely, relative risks for lung cancer in families with increasing numbers of patients with cancers X. However, we lacked information on smoking. The total number of lung cancers in the database was 125 563. We applied stringent statistical criteria and found... (More)

Familial risks of lung cancer are well-established, but whether lung cancer clusters with other discordant cancers is less certain, particularly beyond smoking-related sites, which may provide evidence on genetic contributions to lung cancer aetiology. We used a novel approach to search for familial associations in the Swedish Family-Cancer Database. This involved assessment of familial relative risk for cancer X in families with increasing numbers of lung cancer patients and, conversely, relative risks for lung cancer in families with increasing numbers of patients with cancers X. However, we lacked information on smoking. The total number of lung cancers in the database was 125 563. We applied stringent statistical criteria and found that seven discordant cancers were associated with lung cancer among family members, and six of these were known to be connected with smoking: oesophageal, upper aerodigestive tract, liver, cervical, kidney and urinary bladder cancers. A further novel finding was that cancer of unknown primary also associated with lung cancer. We also factored in histological evidence and found that anal and connective tissue cancers could be associated with lung cancer for reasons other than smoking. For endometrial and prostate cancers, suggestive negative associations with lung cancer were found. Although we lacked information on smoking it is prudent to conclude that practically all observed discordant associations of lung cancer were with cancers for which smoking is a risk factor.

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author
organization
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Contribution to journal
publication status
published
subject
in
ERS Monograph
volume
3
issue
2
external identifiers
  • scopus:85025123377
ISSN
2312-508X
DOI
10.1183/23120541.00006-2017
language
English
LU publication?
yes
id
732af7bb-7ff8-4cdb-9f52-408073b9effa
date added to LUP
2017-08-30 11:17:33
date last changed
2017-08-31 03:00:02
@article{732af7bb-7ff8-4cdb-9f52-408073b9effa,
  abstract     = {<p>Familial risks of lung cancer are well-established, but whether lung cancer clusters with other discordant cancers is less certain, particularly beyond smoking-related sites, which may provide evidence on genetic contributions to lung cancer aetiology. We used a novel approach to search for familial associations in the Swedish Family-Cancer Database. This involved assessment of familial relative risk for cancer X in families with increasing numbers of lung cancer patients and, conversely, relative risks for lung cancer in families with increasing numbers of patients with cancers X. However, we lacked information on smoking. The total number of lung cancers in the database was 125 563. We applied stringent statistical criteria and found that seven discordant cancers were associated with lung cancer among family members, and six of these were known to be connected with smoking: oesophageal, upper aerodigestive tract, liver, cervical, kidney and urinary bladder cancers. A further novel finding was that cancer of unknown primary also associated with lung cancer. We also factored in histological evidence and found that anal and connective tissue cancers could be associated with lung cancer for reasons other than smoking. For endometrial and prostate cancers, suggestive negative associations with lung cancer were found. Although we lacked information on smoking it is prudent to conclude that practically all observed discordant associations of lung cancer were with cancers for which smoking is a risk factor.</p>},
  articleno    = {00006-2017},
  author       = {Yu, Hongyao and Frank, Christoph and Hemminki, Akseli and Sundquist, Kristina and Hemminki, Kari},
  issn         = {2312-508X},
  language     = {eng},
  month        = {04},
  number       = {2},
  series       = {ERS Monograph},
  title        = {Other cancers in lung cancer families are overwhelmingly smoking-related cancers},
  url          = {http://dx.doi.org/10.1183/23120541.00006-2017},
  volume       = {3},
  year         = {2017},
}