Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.
(2012) In PLoS ONE 7(8).- Abstract
- Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3124252
- author
- Cao, Lei LU ; Zhang, Yaping LU ; Cao, Yong-Xiao ; Edvinsson, Lars LU and Xu, Cang-Bao LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 7
- issue
- 8
- article number
- e44170
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000308044800100
- pmid:22952915
- scopus:84865437694
- pmid:22952915
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0044170
- language
- English
- LU publication?
- yes
- id
- 733304be-b795-4682-8916-cd1774ecdcab (old id 3124252)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22952915?dopt=Abstract
- date added to LUP
- 2016-04-01 12:56:57
- date last changed
- 2024-01-09 05:44:08
@article{733304be-b795-4682-8916-cd1774ecdcab, abstract = {{Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.}}, author = {{Cao, Lei and Zhang, Yaping and Cao, Yong-Xiao and Edvinsson, Lars and Xu, Cang-Bao}}, issn = {{1932-6203}}, language = {{eng}}, number = {{8}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.}}, url = {{https://lup.lub.lu.se/search/files/3064288/3563578.pdf}}, doi = {{10.1371/journal.pone.0044170}}, volume = {{7}}, year = {{2012}}, }