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Biodegradable magnesium-based implants in bone studied by synchrotron radiation microtomography

Moosmann, Julian; Zeller-Plumhoff, Berit; Wieland, D. C.Florian; Galli, Silvia; Krüger, Diana; Dose, Thomas; Burmester, Hilmar; Wilde, Fabian; Bech, Martin LU and Peruzzi, Niccolò LU , et al. (2017) Developments in X-Ray Tomography XI 2017 In Developments in X-Ray Tomography XI 10391.
Abstract

Permanent implants made of titanium or its alloys are the gold standard in many orthopedic and traumatological applications due to their good biocompatibility and mechanical properties. However, a second surgical intervention is required for this kind of implants as they have to be removed in the case of children that are still growing or on patient's demand. Therefore, magnesium-based implants are considered for medical applications as they are degraded under physiological conditions. The major challenge is tailoring the degradation in a manner that is suitable for a biological environment and such that stabilization of the bone is provided for a controlled period. In order to understand failure mechanisms of magnesium-based implants... (More)

Permanent implants made of titanium or its alloys are the gold standard in many orthopedic and traumatological applications due to their good biocompatibility and mechanical properties. However, a second surgical intervention is required for this kind of implants as they have to be removed in the case of children that are still growing or on patient's demand. Therefore, magnesium-based implants are considered for medical applications as they are degraded under physiological conditions. The major challenge is tailoring the degradation in a manner that is suitable for a biological environment and such that stabilization of the bone is provided for a controlled period. In order to understand failure mechanisms of magnesium-based implants in orthopedic applications and, further, to better understand the osseointegration, screw implants in bone are studied under mechanical load by means of a push-out device installed at the imaging beamline P05 of PETRA III at DESY. Conventional absorption contrast microtomography and phasecontrast techniques are applied in order to monitor the bone-to-implant interface under increasing load conditions. In this proof-of-concept study, first results from an in situ push-out experiment are presented.

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Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Biodegradable metallic implants, Biodegradation, Bone healing, Bone-implant-interface, In situ mechanical testing, Load frame, Magnesium alloys, MicroCT, Synchrotron radiation, X-ray tomography
in
Developments in X-Ray Tomography XI
volume
10391
publisher
SPIE
conference name
Developments in X-Ray Tomography XI 2017
external identifiers
  • scopus:85040443776
ISBN
9781510612396
DOI
10.1117/12.2275121
language
English
LU publication?
yes
id
734467f2-46e4-4438-9fd3-ee3329ac4bce
date added to LUP
2018-01-22 14:47:32
date last changed
2018-01-22 14:47:32
@inproceedings{734467f2-46e4-4438-9fd3-ee3329ac4bce,
  abstract     = {<p>Permanent implants made of titanium or its alloys are the gold standard in many orthopedic and traumatological applications due to their good biocompatibility and mechanical properties. However, a second surgical intervention is required for this kind of implants as they have to be removed in the case of children that are still growing or on patient's demand. Therefore, magnesium-based implants are considered for medical applications as they are degraded under physiological conditions. The major challenge is tailoring the degradation in a manner that is suitable for a biological environment and such that stabilization of the bone is provided for a controlled period. In order to understand failure mechanisms of magnesium-based implants in orthopedic applications and, further, to better understand the osseointegration, screw implants in bone are studied under mechanical load by means of a push-out device installed at the imaging beamline P05 of PETRA III at DESY. Conventional absorption contrast microtomography and phasecontrast techniques are applied in order to monitor the bone-to-implant interface under increasing load conditions. In this proof-of-concept study, first results from an in situ push-out experiment are presented.</p>},
  author       = {Moosmann, Julian and Zeller-Plumhoff, Berit and Wieland, D. C.Florian and Galli, Silvia and Krüger, Diana and Dose, Thomas and Burmester, Hilmar and Wilde, Fabian and Bech, Martin and Peruzzi, Niccolò and Wiese, Björn and Hipp, Alexander and Beckmann, Felix and Hammel, Jörg and Willumeit-Römer, Regine},
  booktitle    = {Developments in X-Ray Tomography XI},
  isbn         = {9781510612396},
  keyword      = {Biodegradable metallic implants,Biodegradation,Bone healing,Bone-implant-interface,In situ mechanical testing,Load frame,Magnesium alloys,MicroCT,Synchrotron radiation,X-ray tomography},
  language     = {eng},
  publisher    = {SPIE},
  title        = {Biodegradable magnesium-based implants in bone studied by synchrotron radiation microtomography},
  url          = {http://dx.doi.org/10.1117/12.2275121},
  volume       = {10391},
  year         = {2017},
}