Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis.
(2008) In Journal of General Virology 89(Pt 10). p.2467-2474- Abstract
- Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus Betapapillomavirus, and squamous cell carcinoma (SCC) of the skin. As most of these viruses are uncharacterized, molecular characterization and epidemiology are needed to advance our understanding of their significance in carcinogenesis. This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated HPV-107, -110 and -111 and FA75[KI88-03], an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients... (More)
- Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus Betapapillomavirus, and squamous cell carcinoma (SCC) of the skin. As most of these viruses are uncharacterized, molecular characterization and epidemiology are needed to advance our understanding of their significance in carcinogenesis. This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated HPV-107, -110 and -111 and FA75[KI88-03], an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients by HPV type-specific real-time PCR assays. Seventeen patients (6.5 %) harboured at least one of the four HPV types in their lesion, whereas seven patients (2.7 %) harboured one or more of the HPV types in healthy skin. Overall, the four viruses were more common in AK than in healthy skin (odds ratio 5.0, 95 % confidence interval 1.4-17.5), but the prevalence and viral loads were low. This characterization of HPV-107, -110 and -111 and FA75[KI88-03] expands the heterogeneity of members of species 2 of the genus Betapapillomavirus. However, as these types were found in only a few samples and in low amounts, a possible role in carcinogenesis remains elusive. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1242941
- author
- Vasiljevic, Natasa LU ; Hazard, Kristina LU ; Dillner, Joakim LU and Forslund, Ola LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of General Virology
- volume
- 89
- issue
- Pt 10
- pages
- 2467 - 2474
- publisher
- Microbiology Society
- external identifiers
-
- wos:000259829000012
- pmid:18796715
- scopus:54449098227
- ISSN
- 1465-2099
- DOI
- 10.1099/vir.0.2008/001925-0
- language
- English
- LU publication?
- yes
- id
- 73547c10-489d-4764-a734-2b8a55d4af63 (old id 1242941)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18796715?dopt=Abstract
- date added to LUP
- 2016-04-04 09:10:31
- date last changed
- 2022-05-16 23:11:27
@article{73547c10-489d-4764-a734-2b8a55d4af63,
abstract = {{Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus Betapapillomavirus, and squamous cell carcinoma (SCC) of the skin. As most of these viruses are uncharacterized, molecular characterization and epidemiology are needed to advance our understanding of their significance in carcinogenesis. This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated HPV-107, -110 and -111 and FA75[KI88-03], an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients by HPV type-specific real-time PCR assays. Seventeen patients (6.5 %) harboured at least one of the four HPV types in their lesion, whereas seven patients (2.7 %) harboured one or more of the HPV types in healthy skin. Overall, the four viruses were more common in AK than in healthy skin (odds ratio 5.0, 95 % confidence interval 1.4-17.5), but the prevalence and viral loads were low. This characterization of HPV-107, -110 and -111 and FA75[KI88-03] expands the heterogeneity of members of species 2 of the genus Betapapillomavirus. However, as these types were found in only a few samples and in low amounts, a possible role in carcinogenesis remains elusive.}},
author = {{Vasiljevic, Natasa and Hazard, Kristina and Dillner, Joakim and Forslund, Ola}},
issn = {{1465-2099}},
language = {{eng}},
number = {{Pt 10}},
pages = {{2467--2474}},
publisher = {{Microbiology Society}},
series = {{Journal of General Virology}},
title = {{Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis.}},
url = {{http://dx.doi.org/10.1099/vir.0.2008/001925-0}},
doi = {{10.1099/vir.0.2008/001925-0}},
volume = {{89}},
year = {{2008}},
}