A prospective observational study on persistent postoperative pediatric pain, 4P : The study protocol
Broman, Johanna LU
; Nielsen, Niklas
LU
and Persson, Anna K M
LU
(2025)
In PLoS ONE
20.
p.1-10
- Abstract
BACKGROUND: Access to adequate pain treatment is a fundamental right, yet international data suggest that a considerable number of children experience acute and persistent pain. Little is known about the occurrence of both acute and persistent pain in children. The incidence of persistent postoperative pain in children is an unexplored area but international studies suggest that many children experience long-term pain after surgery, with a major impact on daily life. In 4P, Persistent Postoperative Pediatric Pain, we want to estimate the incidence of acute and persistent postoperative pediatric pain. The European Society for Paediatric Anaesthesiology has developed guidelines for perioperative pain management. We aim to examine how well... (More)
BACKGROUND: Access to adequate pain treatment is a fundamental right, yet international data suggest that a considerable number of children experience acute and persistent pain. Little is known about the occurrence of both acute and persistent pain in children. The incidence of persistent postoperative pain in children is an unexplored area but international studies suggest that many children experience long-term pain after surgery, with a major impact on daily life. In 4P, Persistent Postoperative Pediatric Pain, we want to estimate the incidence of acute and persistent postoperative pediatric pain. The European Society for Paediatric Anaesthesiology has developed guidelines for perioperative pain management. We aim to examine how well these guidelines are followed and whether adherence to guidelines influences the pain experienced after surgery.
METHOD: 4P is a prospective observational study of children aged 1-17, planned for surgery in southern Sweden 2023-2024. After agreement from all caregivers, data concerning preoperative pain, pre-emptive analgesia, perioperative management and postoperative pain will be collected. Via an electronic management software, pain will be evaluated at home (or in hospital) at 24h, 3, 6 and 12 months after surgery. We will include 1000 patients.
DISCUSSION: 4P will prospectively follow a large number of children after general pediatric surgeries and evaluate the occurrence of postoperative pain, both acute (APOP) and persistent (PPOP). The study will assess pain treatment regimens and identify risk factors associated with the development of acute and persistent pediatric postoperative pain.
TRIAL REGISTRATION: Prospectively posted at ClinicalTrials.gov, identifier NCT06035042.
(Less)
- author
- Broman, Johanna
LU
; Nielsen, Niklas
LU
and Persson, Anna K M
LU
- organization
- publishing date
- 2025-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Pain, Postoperative/etiology, Child, Prospective Studies, Adolescent, Child, Preschool, Infant, Pain Management/methods, Female, Male, Pain Measurement, Sweden/epidemiology
- in
- PLoS ONE
- volume
- 20
- article number
- e0316533
- pages
- 1 - 10
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:39808613
- scopus:85214991445
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0316533
- language
- English
- LU publication?
- yes
- additional info
- Copyright: © 2025 Broman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- id
- 7371b3b8-915b-4696-ac8d-b4a5c2cf68ab
- date added to LUP
- 2025-03-06 19:18:50
- date last changed
- 2025-05-30 11:17:58
@article{7371b3b8-915b-4696-ac8d-b4a5c2cf68ab,
abstract = {{<p>BACKGROUND: Access to adequate pain treatment is a fundamental right, yet international data suggest that a considerable number of children experience acute and persistent pain. Little is known about the occurrence of both acute and persistent pain in children. The incidence of persistent postoperative pain in children is an unexplored area but international studies suggest that many children experience long-term pain after surgery, with a major impact on daily life. In 4P, Persistent Postoperative Pediatric Pain, we want to estimate the incidence of acute and persistent postoperative pediatric pain. The European Society for Paediatric Anaesthesiology has developed guidelines for perioperative pain management. We aim to examine how well these guidelines are followed and whether adherence to guidelines influences the pain experienced after surgery.</p><p>METHOD: 4P is a prospective observational study of children aged 1-17, planned for surgery in southern Sweden 2023-2024. After agreement from all caregivers, data concerning preoperative pain, pre-emptive analgesia, perioperative management and postoperative pain will be collected. Via an electronic management software, pain will be evaluated at home (or in hospital) at 24h, 3, 6 and 12 months after surgery. We will include 1000 patients.</p><p>DISCUSSION: 4P will prospectively follow a large number of children after general pediatric surgeries and evaluate the occurrence of postoperative pain, both acute (APOP) and persistent (PPOP). The study will assess pain treatment regimens and identify risk factors associated with the development of acute and persistent pediatric postoperative pain.</p><p>TRIAL REGISTRATION: Prospectively posted at ClinicalTrials.gov, identifier NCT06035042.</p>}},
author = {{Broman, Johanna and Nielsen, Niklas and Persson, Anna K M}},
issn = {{1932-6203}},
keywords = {{Humans; Pain, Postoperative/etiology; Child; Prospective Studies; Adolescent; Child, Preschool; Infant; Pain Management/methods; Female; Male; Pain Measurement; Sweden/epidemiology}},
language = {{eng}},
pages = {{1--10}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{A prospective observational study on persistent postoperative pediatric pain, 4P : The study protocol}},
url = {{http://dx.doi.org/10.1371/journal.pone.0316533}},
doi = {{10.1371/journal.pone.0316533}},
volume = {{20}},
year = {{2025}},
}