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The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery

Erixon, Clara LU orcid ; Thelaus, Louise LU ; Johannesson, Emilia LU orcid ; Nilsson, Johan LU orcid ; Teurneau-Hermansson, Karl LU orcid ; Linder, Adam LU ; Ragnarsson, Sigurdur LU ; Sterner, Niklas LU ; Zindovic, Igor LU and Dardashti, Alain LU (2025) In Scandinavian Journal of Clinical and Laboratory Investigation
Abstract

Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, acute kidney injury (AKI) and prolonged mechanical ventilation after valvular surgery. This prospective, observational, single-centre study included 414 patients who underwent valvular cardiac surgery at Skåne University Hospital between 1 February 2020 and 22 September 2021. Early postoperative suPAR levels were measured, and multivariable... (More)

Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, acute kidney injury (AKI) and prolonged mechanical ventilation after valvular surgery. This prospective, observational, single-centre study included 414 patients who underwent valvular cardiac surgery at Skåne University Hospital between 1 February 2020 and 22 September 2021. Early postoperative suPAR levels were measured, and multivariable logistic regression was used to identify significant risk factors for postoperative infection, AKI and prolonged mechanical ventilation. Left ventricular ejection fraction (LVEF) 30-50% (OR 3.57 [1.29-9.86], p = 0.014) and suPAR concentration (OR 1.41 [1.56-1.71], p <0.001) were found to be predictive risk factors for developing postoperative infection. Additionally, suPAR concentration (OR 1.23 [1.05-1.43], p = 0.008), cardiopulmonary bypass (CPB) time (OR 1.01 [1.00-1.02], p = 0.004) and age (OR 1.04 [1.01-1.08], p = 0.007) were found to be predictive risk factors for postoperative AKI. However, suPAR concentration did not predict prolonged mechanical ventilation. Plasma suPAR levels after cardiac valve surgery were found to be predictive of postoperative AKI and infection. Our results indicate that early postoperative suPAR measurements may be a valuable tool for identifying patients at higher risk for developing postoperative complications.

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Contribution to journal
publication status
epub
subject
in
Scandinavian Journal of Clinical and Laboratory Investigation
publisher
Informa Healthcare
external identifiers
  • scopus:105000341579
  • pmid:40088459
ISSN
1502-7686
DOI
10.1080/00365513.2025.2479042
language
English
LU publication?
yes
id
73bab727-e5e0-4409-aaac-20d24150faf7
date added to LUP
2025-03-25 07:30:10
date last changed
2025-07-24 12:53:14
@article{73bab727-e5e0-4409-aaac-20d24150faf7,
  abstract     = {{<p>Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, acute kidney injury (AKI) and prolonged mechanical ventilation after valvular surgery. This prospective, observational, single-centre study included 414 patients who underwent valvular cardiac surgery at Skåne University Hospital between 1 February 2020 and 22 September 2021. Early postoperative suPAR levels were measured, and multivariable logistic regression was used to identify significant risk factors for postoperative infection, AKI and prolonged mechanical ventilation. Left ventricular ejection fraction (LVEF) 30-50% (OR 3.57 [1.29-9.86], p = 0.014) and suPAR concentration (OR 1.41 [1.56-1.71], p &lt;0.001) were found to be predictive risk factors for developing postoperative infection. Additionally, suPAR concentration (OR 1.23 [1.05-1.43], p = 0.008), cardiopulmonary bypass (CPB) time (OR 1.01 [1.00-1.02], p = 0.004) and age (OR 1.04 [1.01-1.08], p = 0.007) were found to be predictive risk factors for postoperative AKI. However, suPAR concentration did not predict prolonged mechanical ventilation. Plasma suPAR levels after cardiac valve surgery were found to be predictive of postoperative AKI and infection. Our results indicate that early postoperative suPAR measurements may be a valuable tool for identifying patients at higher risk for developing postoperative complications.</p>}},
  author       = {{Erixon, Clara and Thelaus, Louise and Johannesson, Emilia and Nilsson, Johan and Teurneau-Hermansson, Karl and Linder, Adam and Ragnarsson, Sigurdur and Sterner, Niklas and Zindovic, Igor and Dardashti, Alain}},
  issn         = {{1502-7686}},
  language     = {{eng}},
  month        = {{03}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical and Laboratory Investigation}},
  title        = {{The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery}},
  url          = {{http://dx.doi.org/10.1080/00365513.2025.2479042}},
  doi          = {{10.1080/00365513.2025.2479042}},
  year         = {{2025}},
}