Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings.
(2014) In BMC Immunology 15(1).- Abstract
- Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a period of 4 years, in four paediatric speciality clinics in Skåne County in southern Sweden, children being seen for infections and fulfilling specific criteria were evaluated according to a predefined examination schedule. The initial analysis consisted of complete blood counts with analysis of lymphocyte subpopulations (T, B, NK cells), measurement... (More)
- Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a period of 4 years, in four paediatric speciality clinics in Skåne County in southern Sweden, children being seen for infections and fulfilling specific criteria were evaluated according to a predefined examination schedule. The initial analysis consisted of complete blood counts with analysis of lymphocyte subpopulations (T, B, NK cells), measurement of immunoglobulins (IgG, IgA, IgM, IgE and IgG subclasses), and assessment of the complement system (classical, alternative and lectin pathways). In addition, results of these immunological analyses in other children from the same area and time period were evaluated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4736875
- author
- Brodszki, Nicholas LU ; Jönsson, Göran LU ; Melander Skattum, Lillemor LU and Truedsson, Lennart LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Immunology
- volume
- 15
- issue
- 1
- article number
- 31
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:25318568
- wos:000341523200001
- scopus:84906927357
- pmid:25318568
- ISSN
- 1471-2172
- DOI
- 10.1186/s12865-014-0031-6
- language
- English
- LU publication?
- yes
- id
- 73f757f1-8089-4fa3-bc2f-40c0cdccde57 (old id 4736875)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25318568?dopt=Abstract
- date added to LUP
- 2016-04-01 15:02:25
- date last changed
- 2022-01-28 03:48:38
@article{73f757f1-8089-4fa3-bc2f-40c0cdccde57, abstract = {{Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a period of 4 years, in four paediatric speciality clinics in Skåne County in southern Sweden, children being seen for infections and fulfilling specific criteria were evaluated according to a predefined examination schedule. The initial analysis consisted of complete blood counts with analysis of lymphocyte subpopulations (T, B, NK cells), measurement of immunoglobulins (IgG, IgA, IgM, IgE and IgG subclasses), and assessment of the complement system (classical, alternative and lectin pathways). In addition, results of these immunological analyses in other children from the same area and time period were evaluated.}}, author = {{Brodszki, Nicholas and Jönsson, Göran and Melander Skattum, Lillemor and Truedsson, Lennart}}, issn = {{1471-2172}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Immunology}}, title = {{Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings.}}, url = {{https://lup.lub.lu.se/search/files/4309411/5422057}}, doi = {{10.1186/s12865-014-0031-6}}, volume = {{15}}, year = {{2014}}, }