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The impact of age on survival of diffuse large B-cell lymphoma - a population-based study

Hedstrom, Gustaf ; Hagberg, Oskar LU ; Jerkeman, Mats LU and Enblad, Gunilla (2015) In Acta Oncologica 54(6). p.916-923
Abstract
Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective cohort study of all Swedish DLBCL patients diagnosed 2000-2013, to evaluate the importance of age at diagnosis for survival of DLBCL patients. Results. In total, 7166 patients were included for further analysis. Survival declined for every 10-year age group and every age group above the age of 39 had a statistically decreased survival compared to... (More)
Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective cohort study of all Swedish DLBCL patients diagnosed 2000-2013, to evaluate the importance of age at diagnosis for survival of DLBCL patients. Results. In total, 7166 patients were included for further analysis. Survival declined for every 10-year age group and every age group above the age of 39 had a statistically decreased survival compared to the reference group of 20-29 years. In an analysis of relative survival, and in a multifactorial model adjusted for stage, ECOG performance status, serum lactate dehydrogenase and involvement of extranodal sites, each age group above age 39 had a significantly higher risk ratio (p = 0.01) compared to the reference group. Conclusion. This is one of the largest population-based studies of DLBCL published to date. In this study, age persisted as a signifi cant adverse risk factor for patients as young as 40 years, even after adjustment for other risk factors. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
54
issue
6
pages
916 - 923
publisher
Taylor & Francis
external identifiers
  • wos:000354479800015
  • scopus:84929320787
  • pmid:25519707
ISSN
1651-226X
DOI
10.3109/0284186X.2014.978367
language
English
LU publication?
yes
id
e6e42337-6fe3-470b-acb7-933720f91c21 (old id 7422672)
date added to LUP
2016-04-01 13:29:12
date last changed
2025-04-04 14:01:12
@article{e6e42337-6fe3-470b-acb7-933720f91c21,
  abstract     = {{Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective cohort study of all Swedish DLBCL patients diagnosed 2000-2013, to evaluate the importance of age at diagnosis for survival of DLBCL patients. Results. In total, 7166 patients were included for further analysis. Survival declined for every 10-year age group and every age group above the age of 39 had a statistically decreased survival compared to the reference group of 20-29 years. In an analysis of relative survival, and in a multifactorial model adjusted for stage, ECOG performance status, serum lactate dehydrogenase and involvement of extranodal sites, each age group above age 39 had a significantly higher risk ratio (p = 0.01) compared to the reference group. Conclusion. This is one of the largest population-based studies of DLBCL published to date. In this study, age persisted as a signifi cant adverse risk factor for patients as young as 40 years, even after adjustment for other risk factors.}},
  author       = {{Hedstrom, Gustaf and Hagberg, Oskar and Jerkeman, Mats and Enblad, Gunilla}},
  issn         = {{1651-226X}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{916--923}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta Oncologica}},
  title        = {{The impact of age on survival of diffuse large B-cell lymphoma - a population-based study}},
  url          = {{https://lup.lub.lu.se/search/files/3399994/8523575.pdf}},
  doi          = {{10.3109/0284186X.2014.978367}},
  volume       = {{54}},
  year         = {{2015}},
}