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Brain changes in dementia of Alzheimer's type relevant to new imaging diagnostic methods

Brun, A LU and Englund, E LU orcid (1986) In Progress in Neuro-Psychopharmacology and Biological Psychiatry 10(3-5). p.297-308
Abstract

The aim of the article is to correlate grey and white matter changes and their topography to the results of modern methods for brain imaging such as CT, rCBF, PET, SPECT and NMR in Alzheimer's type of dementia. The findings are based on the study of a large material investigated thoroughly patho-anatomically. The findings are correlated with psychiatric and neurophysiologic follow-up studies. The degenerative grey matter process shows a regionally varying accent according to a pattern which is consistent and typical for the disease. This corresponds to metabolic changes on rCBF, PET and SPECT and thereby becomes of diagnostic value. This pattern is largely symmetric. Metabolic asymmetries have however been reported on PET scans. In this... (More)

The aim of the article is to correlate grey and white matter changes and their topography to the results of modern methods for brain imaging such as CT, rCBF, PET, SPECT and NMR in Alzheimer's type of dementia. The findings are based on the study of a large material investigated thoroughly patho-anatomically. The findings are correlated with psychiatric and neurophysiologic follow-up studies. The degenerative grey matter process shows a regionally varying accent according to a pattern which is consistent and typical for the disease. This corresponds to metabolic changes on rCBF, PET and SPECT and thereby becomes of diagnostic value. This pattern is largely symmetric. Metabolic asymmetries have however been reported on PET scans. In this context individual variations of the topographic degenerative brain pattern and normal anatomical brain asymmetries are of interest. The white matter however also frequently shows changes, in particular loss of myelin and axons and a mild gliosis, slight in 1/3 of the cases and severe in an additional 1/3. These changes cause a decrease of density in the centrum semiovale correlating to lipid depletion. They may also influence the ventricular shape and size, of interest in CT or NMR studies. Also here variations in ventricular shape, normal and such due to pathological processes unrelated to the Alzheimer disease, may cause confusion, regarding degree of atrophy and even type of brain process. Such factors should be considered in the interpretation of non-invasive brain studies.

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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Alzheimer Disease/pathology, Atrophy, Brain/pathology, Humans, Lipids/analysis, Magnetic Resonance Spectroscopy, Myelin Sheath/analysis, Tomography, Emission-Computed, Tomography, X-Ray Computed
in
Progress in Neuro-Psychopharmacology and Biological Psychiatry
volume
10
issue
3-5
pages
297 - 308
publisher
Elsevier
external identifiers
  • scopus:0022997632
  • pmid:3492011
ISSN
0278-5846
DOI
10.1016/0278-5846(86)90009-6
language
English
LU publication?
yes
id
74320641-5c23-4b92-b7fa-fe133c45f08c
date added to LUP
2023-07-25 16:42:18
date last changed
2024-04-20 01:00:43
@article{74320641-5c23-4b92-b7fa-fe133c45f08c,
  abstract     = {{<p>The aim of the article is to correlate grey and white matter changes and their topography to the results of modern methods for brain imaging such as CT, rCBF, PET, SPECT and NMR in Alzheimer's type of dementia. The findings are based on the study of a large material investigated thoroughly patho-anatomically. The findings are correlated with psychiatric and neurophysiologic follow-up studies. The degenerative grey matter process shows a regionally varying accent according to a pattern which is consistent and typical for the disease. This corresponds to metabolic changes on rCBF, PET and SPECT and thereby becomes of diagnostic value. This pattern is largely symmetric. Metabolic asymmetries have however been reported on PET scans. In this context individual variations of the topographic degenerative brain pattern and normal anatomical brain asymmetries are of interest. The white matter however also frequently shows changes, in particular loss of myelin and axons and a mild gliosis, slight in 1/3 of the cases and severe in an additional 1/3. These changes cause a decrease of density in the centrum semiovale correlating to lipid depletion. They may also influence the ventricular shape and size, of interest in CT or NMR studies. Also here variations in ventricular shape, normal and such due to pathological processes unrelated to the Alzheimer disease, may cause confusion, regarding degree of atrophy and even type of brain process. Such factors should be considered in the interpretation of non-invasive brain studies.</p>}},
  author       = {{Brun, A and Englund, E}},
  issn         = {{0278-5846}},
  keywords     = {{Aging; Alzheimer Disease/pathology; Atrophy; Brain/pathology; Humans; Lipids/analysis; Magnetic Resonance Spectroscopy; Myelin Sheath/analysis; Tomography, Emission-Computed; Tomography, X-Ray Computed}},
  language     = {{eng}},
  number       = {{3-5}},
  pages        = {{297--308}},
  publisher    = {{Elsevier}},
  series       = {{Progress in Neuro-Psychopharmacology and Biological Psychiatry}},
  title        = {{Brain changes in dementia of Alzheimer's type relevant to new imaging diagnostic methods}},
  url          = {{http://dx.doi.org/10.1016/0278-5846(86)90009-6}},
  doi          = {{10.1016/0278-5846(86)90009-6}},
  volume       = {{10}},
  year         = {{1986}},
}