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Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction

Oredsson, Stina LU ; Alm, Kersti LU ; Dahlberg, Ewa LU ; Holst, Martina LU ; Johansson, Veronica LU ; Myhre, Louise LU and Söderstjerna, Erika LU (2007) In Biochemical Society Transactions 35(2). p.405-409
Abstract
Reduction of cellular polyamine pools results in inhibition of cell proliferation and sometimes in induction of cell death. Reduction of cellular polyamine pools can be achieved by several strategies involving all the mechanisms of polyamine homoeostasis, i.e. biosynthesis, catabolism and transport across the cell membrane. In the present paper, we concentrate on results achieved using the polyamine analogue DENSPM (N(1),N(11)-diethylnorspermine) on different cell lines. We discuss polyamine levels in DENSPM-treated cells in relation to effects on cell cycle kinetics and induction of apoptosis. To really understand the role of polyamines in cell cycle regulation and apoptosis, we believe it is now time to go through the vast polyamine... (More)
Reduction of cellular polyamine pools results in inhibition of cell proliferation and sometimes in induction of cell death. Reduction of cellular polyamine pools can be achieved by several strategies involving all the mechanisms of polyamine homoeostasis, i.e. biosynthesis, catabolism and transport across the cell membrane. In the present paper, we concentrate on results achieved using the polyamine analogue DENSPM (N(1),N(11)-diethylnorspermine) on different cell lines. We discuss polyamine levels in DENSPM-treated cells in relation to effects on cell cycle kinetics and induction of apoptosis. To really understand the role of polyamines in cell cycle regulation and apoptosis, we believe it is now time to go through the vast polyamine literature in a meta-analysis-based manner. This short review does not claim to be such a study, but it is our hope to stimulate such studies in the polyamine field. Such work is especially important from the viewpoint of introducing drugs that affect polyamine homoeostasis in the treatment of various diseases such as cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
polyamine analogue, breast cancer, apoptosis, cell cycle, oxidative stress, neuroblastoma
in
Biochemical Society Transactions
volume
35
issue
2
pages
405 - 409
publisher
Biochemical Society
external identifiers
  • wos:000245705800059
ISSN
0300-5127
language
English
LU publication?
yes
id
328106dd-2a21-4aab-b52e-d068e495a4d9 (old id 744612)
alternative location
http://www.biochemsoctrans.org/bst/035/0405/0350405.pdf
date added to LUP
2007-12-12 14:57:33
date last changed
2016-04-15 20:26:25
@article{328106dd-2a21-4aab-b52e-d068e495a4d9,
  abstract     = {Reduction of cellular polyamine pools results in inhibition of cell proliferation and sometimes in induction of cell death. Reduction of cellular polyamine pools can be achieved by several strategies involving all the mechanisms of polyamine homoeostasis, i.e. biosynthesis, catabolism and transport across the cell membrane. In the present paper, we concentrate on results achieved using the polyamine analogue DENSPM (N(1),N(11)-diethylnorspermine) on different cell lines. We discuss polyamine levels in DENSPM-treated cells in relation to effects on cell cycle kinetics and induction of apoptosis. To really understand the role of polyamines in cell cycle regulation and apoptosis, we believe it is now time to go through the vast polyamine literature in a meta-analysis-based manner. This short review does not claim to be such a study, but it is our hope to stimulate such studies in the polyamine field. Such work is especially important from the viewpoint of introducing drugs that affect polyamine homoeostasis in the treatment of various diseases such as cancer.},
  author       = {Oredsson, Stina and Alm, Kersti and Dahlberg, Ewa and Holst, Martina and Johansson, Veronica and Myhre, Louise and Söderstjerna, Erika},
  issn         = {0300-5127},
  keyword      = {polyamine analogue,breast cancer,apoptosis,cell cycle,oxidative stress,neuroblastoma},
  language     = {eng},
  number       = {2},
  pages        = {405--409},
  publisher    = {Biochemical Society},
  series       = {Biochemical Society Transactions},
  title        = {Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction},
  volume       = {35},
  year         = {2007},
}