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Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury in a Porcine Model.

Kilbaugh, Todd J ; Lvova, Maria ; Karlsson, Michael LU ; Zhang, Zhe ; Leipzig, Jeremy ; Wallace, Douglas C and Margulies, Susan S (2015) In PLoS ONE 10(6).
Abstract
Traumatic brain injury (TBI) has been shown to activate the peripheral innate immune system and systemic inflammatory response, possibly through the central release of damage associated molecular patterns (DAMPs). Our main purpose was to gain an initial understanding of the peripheral mitochondrial response following TBI, and how this response could be utilized to determine cerebral mitochondrial bioenergetics. We hypothesized that TBI would increase peripheral whole blood relative mtDNA copy number, and that these alterations would be associated with cerebral mitochondrial bioenergetics triggered by TBI.
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
10
issue
6
article number
e0130927
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:26098565
  • wos:000356835800123
  • scopus:84939152663
  • pmid:26098565
ISSN
1932-6203
DOI
10.1371/journal.pone.0130927
language
English
LU publication?
yes
id
862e0c5f-86d4-46b2-8d5f-c14287b06d8d (old id 7478536)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26098565?dopt=Abstract
date added to LUP
2016-04-01 13:55:03
date last changed
2022-04-14 03:54:56
@article{862e0c5f-86d4-46b2-8d5f-c14287b06d8d,
  abstract     = {{Traumatic brain injury (TBI) has been shown to activate the peripheral innate immune system and systemic inflammatory response, possibly through the central release of damage associated molecular patterns (DAMPs). Our main purpose was to gain an initial understanding of the peripheral mitochondrial response following TBI, and how this response could be utilized to determine cerebral mitochondrial bioenergetics. We hypothesized that TBI would increase peripheral whole blood relative mtDNA copy number, and that these alterations would be associated with cerebral mitochondrial bioenergetics triggered by TBI.}},
  author       = {{Kilbaugh, Todd J and Lvova, Maria and Karlsson, Michael and Zhang, Zhe and Leipzig, Jeremy and Wallace, Douglas C and Margulies, Susan S}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury in a Porcine Model.}},
  url          = {{https://lup.lub.lu.se/search/files/3663355/8841251}},
  doi          = {{10.1371/journal.pone.0130927}},
  volume       = {{10}},
  year         = {{2015}},
}