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Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range.

Andersen, Jorunn M; Herning, Hilde; Aschim, Elin L; Hjelmesæth, Jøran; Mala, Tom; Hanevik, Hans Ivar; Bungum, Mona LU ; Haugen, Trine B and Witczak, Oliwia (2015) In PLoS ONE 10(6).
Abstract
There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B =... (More)
There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B = -0.378, P < 0.001), sex hormone binding globulin (B = -0.572, P < 0.001), inhibin B (B = -3.120, P < 0.001) and anti-Müllerian hormone (AMH) (B = -0.009, P < 0.001). Our findings suggest that high BMI is negatively associated with semen characteristics and serum levels of AMH. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
10
issue
6
publisher
Public Library of Science
external identifiers
  • pmid:26067627
  • wos:000356327000151
  • scopus:84936163972
ISSN
1932-6203
DOI
10.1371/journal.pone.0130210
language
English
LU publication?
yes
id
6bf3ab7c-4268-4fe7-8b46-b17db70136eb (old id 7486779)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26067627?dopt=Abstract
date added to LUP
2015-07-08 11:54:01
date last changed
2017-06-11 04:17:50
@article{6bf3ab7c-4268-4fe7-8b46-b17db70136eb,
  abstract     = {There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B = -0.378, P &lt; 0.001), sex hormone binding globulin (B = -0.572, P &lt; 0.001), inhibin B (B = -3.120, P &lt; 0.001) and anti-Müllerian hormone (AMH) (B = -0.009, P &lt; 0.001). Our findings suggest that high BMI is negatively associated with semen characteristics and serum levels of AMH.},
  articleno    = {e0130210},
  author       = {Andersen, Jorunn M and Herning, Hilde and Aschim, Elin L and Hjelmesæth, Jøran and Mala, Tom and Hanevik, Hans Ivar and Bungum, Mona and Haugen, Trine B and Witczak, Oliwia},
  issn         = {1932-6203},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0130210},
  volume       = {10},
  year         = {2015},
}