Advanced

Hippocampal volume and functional connectivity changes during the female menstrual cycle.

Lisofsky, Nina; Mårtensson, Johan LU ; Eckert, Anne; Lindenberger, Ulman; Gallinat, Jürgen and Kühn, Simone (2015) In NeuroImage 118. p.154-162
Abstract
Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle. Here, we examine this covariation with a multi-method approach that includes several brain imaging methods and hormonal assessments. We acquired structural and functional scans from 21 naturally cycling women on four time points during their cycles (early follicular phase, late follicular phase, ovulation and luteal phase). Hormone blood concentrations and cognitive performance in different domains were assessed on each of the measurement occasions. Structural MRI images were... (More)
Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle. Here, we examine this covariation with a multi-method approach that includes several brain imaging methods and hormonal assessments. We acquired structural and functional scans from 21 naturally cycling women on four time points during their cycles (early follicular phase, late follicular phase, ovulation and luteal phase). Hormone blood concentrations and cognitive performance in different domains were assessed on each of the measurement occasions. Structural MRI images were processed by means of whole-brain voxel-based morphometry and FreeSurfer. With either method, bilateral increases in hippocampal volume were found in the late follicular phase relative to the early follicular phase. The gray matter probability in regions of hippocampal volume increase was associated with lower mean diffusivity in the same region. In addition, we observed higher functional connectivity between the hippocampi and the bilateral superior parietal lobe in the late follicular phase. We did not find any reliable cycle-related performance variations on the cognitive tasks. The present results show that hormonal fluctuations covary with hippocampal structure and function in the course of the human menstrual cycle. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroImage
volume
118
pages
154 - 162
publisher
Elsevier
external identifiers
  • pmid:26057590
  • wos:000360630200015
  • scopus:84937604489
ISSN
1095-9572
DOI
10.1016/j.neuroimage.2015.06.012
language
English
LU publication?
yes
id
7dbf09ac-1960-464b-ab77-c9e03148fbce (old id 7487290)
date added to LUP
2015-07-09 10:23:34
date last changed
2017-09-03 03:24:33
@article{7dbf09ac-1960-464b-ab77-c9e03148fbce,
  abstract     = {Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle. Here, we examine this covariation with a multi-method approach that includes several brain imaging methods and hormonal assessments. We acquired structural and functional scans from 21 naturally cycling women on four time points during their cycles (early follicular phase, late follicular phase, ovulation and luteal phase). Hormone blood concentrations and cognitive performance in different domains were assessed on each of the measurement occasions. Structural MRI images were processed by means of whole-brain voxel-based morphometry and FreeSurfer. With either method, bilateral increases in hippocampal volume were found in the late follicular phase relative to the early follicular phase. The gray matter probability in regions of hippocampal volume increase was associated with lower mean diffusivity in the same region. In addition, we observed higher functional connectivity between the hippocampi and the bilateral superior parietal lobe in the late follicular phase. We did not find any reliable cycle-related performance variations on the cognitive tasks. The present results show that hormonal fluctuations covary with hippocampal structure and function in the course of the human menstrual cycle.},
  author       = {Lisofsky, Nina and Mårtensson, Johan and Eckert, Anne and Lindenberger, Ulman and Gallinat, Jürgen and Kühn, Simone},
  issn         = {1095-9572},
  language     = {eng},
  pages        = {154--162},
  publisher    = {Elsevier},
  series       = {NeuroImage},
  title        = {Hippocampal volume and functional connectivity changes during the female menstrual cycle.},
  url          = {http://dx.doi.org/10.1016/j.neuroimage.2015.06.012},
  volume       = {118},
  year         = {2015},
}