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Age and gender specific normal values of left ventricular mass, volume and function for gradient echo magnetic resonance imaging: a cross sectional study

Cain, Peter A LU ; Ahl, Ragnhild; Hedström, Erik LU ; Ugander, Martin LU ; Allansdotter-Johnsson, Ase; Friberg, Peter and Arheden, Håkan LU (2009) In BMC Medical Imaging 9.
Abstract

BACKGROUND: Knowledge about age-specific normal values for left ventricular mass (LVM), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) by cardiac magnetic resonance imaging (CMR) is of importance to differentiate between health and disease and to assess the severity of disease. The aims of the study were to determine age and gender specific normal reference values and to explore the normal physiological variation of these parameters from adolescence to late adulthood, in a cross sectional study.

METHODS: Gradient echo CMR was performed at 1.5 T in 96 healthy volunteers (11-81 years, 50 male). Gender-specific analysis of parameters was undertaken in both absolute values and... (More)

BACKGROUND: Knowledge about age-specific normal values for left ventricular mass (LVM), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) by cardiac magnetic resonance imaging (CMR) is of importance to differentiate between health and disease and to assess the severity of disease. The aims of the study were to determine age and gender specific normal reference values and to explore the normal physiological variation of these parameters from adolescence to late adulthood, in a cross sectional study.

METHODS: Gradient echo CMR was performed at 1.5 T in 96 healthy volunteers (11-81 years, 50 male). Gender-specific analysis of parameters was undertaken in both absolute values and adjusted for body surface area (BSA).

RESULTS: Age and gender specific normal ranges for LV volumes, mass and function are presented from the second through the eighth decade of life. LVM, ESV and EDV rose during adolescence and declined in adulthood. SV and EF decreased with age. Compared to adult females, adult males had higher BSA-adjusted values of EDV (p = 0.006) and ESV (p < 0.001), similar SV (p = 0.51) and lower EF (p = 0.014). No gender differences were seen in the youngest, 11-15 year, age range.

CONCLUSION: LV volumes, mass and function vary over a broad age range in healthy individuals. LV volumes and mass both rise in adolescence and decline with age. EF showed a rapid decline in adolescence compared to changes throughout adulthood. These findings demonstrate the need for age and gender specific normal ranges for clinical use.

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organization
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published
subject
keywords
Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Cross-Sectional Studies, Echo-Planar Imaging, Female, Heart Ventricles, Humans, Male, Middle Aged, Organ Size, Reference Values, Reproducibility of Results, Sensitivity and Specificity, Sex Distribution, Stroke Volume, Sweden, Ventricular Function, Left, Young Adult
in
BMC Medical Imaging
volume
9
pages
10 pages
publisher
BioMed Central
external identifiers
  • scopus:63549139570
ISSN
1471-2342
DOI
10.1186/1471-2342-9-2
language
English
LU publication?
yes
id
749af4c1-f5c9-446a-a458-e1528940e45f
date added to LUP
2017-02-02 11:27:59
date last changed
2017-11-19 04:37:13
@article{749af4c1-f5c9-446a-a458-e1528940e45f,
  abstract     = {<p>BACKGROUND: Knowledge about age-specific normal values for left ventricular mass (LVM), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) by cardiac magnetic resonance imaging (CMR) is of importance to differentiate between health and disease and to assess the severity of disease. The aims of the study were to determine age and gender specific normal reference values and to explore the normal physiological variation of these parameters from adolescence to late adulthood, in a cross sectional study.</p><p>METHODS: Gradient echo CMR was performed at 1.5 T in 96 healthy volunteers (11-81 years, 50 male). Gender-specific analysis of parameters was undertaken in both absolute values and adjusted for body surface area (BSA).</p><p>RESULTS: Age and gender specific normal ranges for LV volumes, mass and function are presented from the second through the eighth decade of life. LVM, ESV and EDV rose during adolescence and declined in adulthood. SV and EF decreased with age. Compared to adult females, adult males had higher BSA-adjusted values of EDV (p = 0.006) and ESV (p &lt; 0.001), similar SV (p = 0.51) and lower EF (p = 0.014). No gender differences were seen in the youngest, 11-15 year, age range.</p><p>CONCLUSION: LV volumes, mass and function vary over a broad age range in healthy individuals. LV volumes and mass both rise in adolescence and decline with age. EF showed a rapid decline in adolescence compared to changes throughout adulthood. These findings demonstrate the need for age and gender specific normal ranges for clinical use.</p>},
  author       = {Cain, Peter A and Ahl, Ragnhild and Hedström, Erik and Ugander, Martin and Allansdotter-Johnsson, Ase and Friberg, Peter and Arheden, Håkan},
  issn         = {1471-2342},
  keyword      = {Adolescent,Adult,Age Distribution,Aged,Aged, 80 and over,Child,Cross-Sectional Studies,Echo-Planar Imaging,Female,Heart Ventricles,Humans,Male,Middle Aged,Organ Size,Reference Values,Reproducibility of Results,Sensitivity and Specificity,Sex Distribution,Stroke Volume,Sweden,Ventricular Function, Left,Young Adult},
  language     = {eng},
  month        = {01},
  pages        = {10},
  publisher    = {BioMed Central},
  series       = {BMC Medical Imaging},
  title        = {Age and gender specific normal values of left ventricular mass, volume and function for gradient echo magnetic resonance imaging: a cross sectional study},
  url          = {http://dx.doi.org/10.1186/1471-2342-9-2},
  volume       = {9},
  year         = {2009},
}