Inherited kidney disease and CAKUT are common causes of kidney failure requiring kidney replacement therapy : an ERA Registry study
(2025) In Nephrology Dialysis Transplantation 40(5). p.1020-1031- Abstract
Background. Inherited kidney diseases (IKDs) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the primary renal disease(PRD) category ‘miscellaneous’ or in the glomerulonephritis or pyelonephritis categories. This makes IKDs invisible (except for polycystic kidney disease) and may negatively influence the use of genetic testing, which may identify a cause for IKDs and some CAKUT. Methods. We re-examined the aetiology of KRT by composing a separate IKD and CAKUT PRD group using data from the European Renal Association (ERA) Registry. Results. In 2019, IKD-CAKUT was the fourth most common cause of... (More)
Background. Inherited kidney diseases (IKDs) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the primary renal disease(PRD) category ‘miscellaneous’ or in the glomerulonephritis or pyelonephritis categories. This makes IKDs invisible (except for polycystic kidney disease) and may negatively influence the use of genetic testing, which may identify a cause for IKDs and some CAKUT. Methods. We re-examined the aetiology of KRT by composing a separate IKD and CAKUT PRD group using data from the European Renal Association (ERA) Registry. Results. In 2019, IKD-CAKUT was the fourth most common cause of kidney failure among incident KRT patients, accounting for 8.9% of cases [IKD 7.4% (including 5.0% autosomal dominant polycystic kidney disease), CAKUT 1.5%], behind diabetes (23.0%), hypertension (14.4%) and glomerulonephritis (10.6%). IKD-CAKUT was the most common cause of kidney failure among patients <20 years of age (41.0% of cases), but their incidence rate was highest among those ages 45–74 years (22.5 per million age-related population). Among prevalent KRT patients, IKD-CAKUT (18.5%) and glomerulonephritis (18.7%) were the two most common causes of kidney failure overall, while IKD-CAKUT was the most common cause in women (21.6%) and in patients <45 years of age (29.1%). Conclusion. IKD and CAKUT are common causes of kidney failure among KRT patients. Distinct categorization of IKD and CAKUT better characterizes the epidemiology of the causes of chronic kidney disease (CKD) and highlights the importance of genetic testing in the diagnostic workup of CKD.
(Less)
- author
- Ortiz, Alberto
; Kramer, Anneke
; Ariceta, Gema
; Rodríguez Arévalo, Olga L.
; Gjerstad, Ann C.
; Santiuste, Carmen
; Trujillo-Alemán, Sara
; Ferraro, Pietro Manuel
; Methven, Shona
; Santamaría, Rafael
; Naumovic, Radomir
; Resic, Halima
; Hommel, Kristine
; Segelmark, Mårten
LU
; Ambühl, Patrice M.
; Sorensen, Søren S.
; Parmentier, Cyrielle
; Vidal, Enrico
; Bakkaloglu, Sevcan A.
; Plumb, Lucy
; Palsson, Runolfur
; Kerschbaum, Julia
; ten Dam, Marc A.G.J.
; Stel, Vianda S.
; Jager, Kitty J.
and Torra, Roser
(Less) - organization
- publishing date
- 2025-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aetiology, CAKUT, epidemiology, genetic kidney disease, inherited kidney disease, kidney failure, kidney replacement therapy
- in
- Nephrology Dialysis Transplantation
- volume
- 40
- issue
- 5
- pages
- 12 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:105003878471
- pmid:39508350
- ISSN
- 0931-0509
- DOI
- 10.1093/ndt/gfae240
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.
- id
- 74be0b6e-b94d-420f-b99e-ac25118ba48b
- date added to LUP
- 2025-08-05 15:22:27
- date last changed
- 2025-08-19 16:38:08
@article{74be0b6e-b94d-420f-b99e-ac25118ba48b,
abstract = {{<p>Background. Inherited kidney diseases (IKDs) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the primary renal disease(PRD) category ‘miscellaneous’ or in the glomerulonephritis or pyelonephritis categories. This makes IKDs invisible (except for polycystic kidney disease) and may negatively influence the use of genetic testing, which may identify a cause for IKDs and some CAKUT. Methods. We re-examined the aetiology of KRT by composing a separate IKD and CAKUT PRD group using data from the European Renal Association (ERA) Registry. Results. In 2019, IKD-CAKUT was the fourth most common cause of kidney failure among incident KRT patients, accounting for 8.9% of cases [IKD 7.4% (including 5.0% autosomal dominant polycystic kidney disease), CAKUT 1.5%], behind diabetes (23.0%), hypertension (14.4%) and glomerulonephritis (10.6%). IKD-CAKUT was the most common cause of kidney failure among patients <20 years of age (41.0% of cases), but their incidence rate was highest among those ages 45–74 years (22.5 per million age-related population). Among prevalent KRT patients, IKD-CAKUT (18.5%) and glomerulonephritis (18.7%) were the two most common causes of kidney failure overall, while IKD-CAKUT was the most common cause in women (21.6%) and in patients <45 years of age (29.1%). Conclusion. IKD and CAKUT are common causes of kidney failure among KRT patients. Distinct categorization of IKD and CAKUT better characterizes the epidemiology of the causes of chronic kidney disease (CKD) and highlights the importance of genetic testing in the diagnostic workup of CKD.</p>}},
author = {{Ortiz, Alberto and Kramer, Anneke and Ariceta, Gema and Rodríguez Arévalo, Olga L. and Gjerstad, Ann C. and Santiuste, Carmen and Trujillo-Alemán, Sara and Ferraro, Pietro Manuel and Methven, Shona and Santamaría, Rafael and Naumovic, Radomir and Resic, Halima and Hommel, Kristine and Segelmark, Mårten and Ambühl, Patrice M. and Sorensen, Søren S. and Parmentier, Cyrielle and Vidal, Enrico and Bakkaloglu, Sevcan A. and Plumb, Lucy and Palsson, Runolfur and Kerschbaum, Julia and ten Dam, Marc A.G.J. and Stel, Vianda S. and Jager, Kitty J. and Torra, Roser}},
issn = {{0931-0509}},
keywords = {{aetiology; CAKUT; epidemiology; genetic kidney disease; inherited kidney disease; kidney failure; kidney replacement therapy}},
language = {{eng}},
month = {{05}},
number = {{5}},
pages = {{1020--1031}},
publisher = {{Oxford University Press}},
series = {{Nephrology Dialysis Transplantation}},
title = {{Inherited kidney disease and CAKUT are common causes of kidney failure requiring kidney replacement therapy : an ERA Registry study}},
url = {{http://dx.doi.org/10.1093/ndt/gfae240}},
doi = {{10.1093/ndt/gfae240}},
volume = {{40}},
year = {{2025}},
}