Advanced

Prevalence of coeliac disease in Turner syndrome

Ivarsson, S-A; Carlsson, A. LU ; Bredberg, A. LU ; Alm, J.; Aronsson, S; Gustafsson, J.; Hagenäs, Lars; Häger, A.; Kriström, Berit and Marcus, C, et al. (1999) In Acta Pædiatrica 88(9). p.933-936
Abstract
This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA- antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA- positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified... (More)
This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA- antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA- positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome. (Less)
Please use this url to cite or link to this publication:
@article{74e3dee9-8398-4967-bb9a-67c008eec59d,
  abstract     = {This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA- antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA- positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome.},
  author       = {Ivarsson, S-A and Carlsson, A. and Bredberg, A. and Alm, J. and Aronsson, S and Gustafsson, J. and Hagenäs, Lars and Häger, A. and Kriström, Berit and Marcus, C and Moëll, C. and Nilsson, K.O. and Tuvemo, T and Westphal, O and Albertsson-Wikland, K and Åman, J},
  issn         = {1651-2227},
  keyword      = {Coeliac disease,IgA-antiendomysium antibodies,IgA-antigliadin antibodies,Turner syndrome,endomysium antibody,gliadin antibody,immunoglobulin A,adolescent,article,celiac disease,child,clinical trial,controlled clinical trial,controlled study,female,human,immunological parameters,intestine biopsy,intestine villus atrophy,major clinical study,multicenter study,priority journal,Sweden},
  language     = {eng},
  month        = {11},
  number       = {9},
  pages        = {933--936},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Prevalence of coeliac disease in Turner syndrome},
  url          = {http://dx.doi.org/10.1080/08035259950168397},
  volume       = {88},
  year         = {1999},
}