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3-D Image-Based Dosimetry in Radionuclide Therapy

Ljungberg, M. LU and Sjögreen Gleisner, K. LU (2018) In IEEE Transactions on Radiation and Plasma Medical Sciences 2(6). p.527-540
Abstract
Radionuclide therapy is the use of radioactive drugs for internal radiotherapy, mainly for the treatment of metastatic disease. As opposed to systemic cancer therapies in general, the use of radioactively labeled drugs results not only in a targeted therapy but also the possibility of imaging the distribution of the drug during therapy. From such images, the absorbed doses delivered to tumors and organs at risk can be calculated. Calculation of the absorbed dose from 3-D images such as single-photon emission computed tomography (SPECT)/CT, and in some cases positron emission tomography (PET)/CT, relies on image-based activity quantification. Quantification is accomplished by modeling the physics involved in the image-formation process, and... (More)
Radionuclide therapy is the use of radioactive drugs for internal radiotherapy, mainly for the treatment of metastatic disease. As opposed to systemic cancer therapies in general, the use of radioactively labeled drugs results not only in a targeted therapy but also the possibility of imaging the distribution of the drug during therapy. From such images, the absorbed doses delivered to tumors and organs at risk can be calculated. Calculation of the absorbed dose from 3-D images such as single-photon emission computed tomography (SPECT)/CT, and in some cases positron emission tomography (PET)/CT, relies on image-based activity quantification. Quantification is accomplished by modeling the physics involved in the image-formation process, and applying image-processing methods. From a time-sequence of such quantitative images, the absorbed doses are then calculated. Although individual-patient dosimetry is a standard component of other forms of radiotherapy, it is still overlooked in the majority of radionuclide therapies. In this review, we summarize the physical and technical problems that need to be addressed in image-based dosimetry. The focus is on SPECT, since most of the radionuclides used are single-photon emitters, although the use of PET is also discussed. Practical issues of relevance for the practical implementation of personalized dosimetry in radionuclide therapy are also highlighted. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
IEEE Transactions on Radiation and Plasma Medical Sciences
volume
2
issue
6
pages
527 - 540
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • scopus:85088794323
ISSN
2469-7311
DOI
10.1109/TRPMS.2018.2860563
language
English
LU publication?
yes
id
74e6e763-8306-42a1-9594-610a70a87b74
date added to LUP
2019-05-09 15:10:12
date last changed
2022-04-25 23:28:25
@article{74e6e763-8306-42a1-9594-610a70a87b74,
  abstract     = {{Radionuclide therapy is the use of radioactive drugs for internal radiotherapy, mainly for the treatment of metastatic disease. As opposed to systemic cancer therapies in general, the use of radioactively labeled drugs results not only in a targeted therapy but also the possibility of imaging the distribution of the drug during therapy. From such images, the absorbed doses delivered to tumors and organs at risk can be calculated. Calculation of the absorbed dose from 3-D images such as single-photon emission computed tomography (SPECT)/CT, and in some cases positron emission tomography (PET)/CT, relies on image-based activity quantification. Quantification is accomplished by modeling the physics involved in the image-formation process, and applying image-processing methods. From a time-sequence of such quantitative images, the absorbed doses are then calculated. Although individual-patient dosimetry is a standard component of other forms of radiotherapy, it is still overlooked in the majority of radionuclide therapies. In this review, we summarize the physical and technical problems that need to be addressed in image-based dosimetry. The focus is on SPECT, since most of the radionuclides used are single-photon emitters, although the use of PET is also discussed. Practical issues of relevance for the practical implementation of personalized dosimetry in radionuclide therapy are also highlighted.}},
  author       = {{Ljungberg, M. and Sjögreen Gleisner, K.}},
  issn         = {{2469-7311}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{6}},
  pages        = {{527--540}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  series       = {{IEEE Transactions on Radiation and Plasma Medical Sciences}},
  title        = {{3-D Image-Based Dosimetry in Radionuclide Therapy}},
  url          = {{http://dx.doi.org/10.1109/TRPMS.2018.2860563}},
  doi          = {{10.1109/TRPMS.2018.2860563}},
  volume       = {{2}},
  year         = {{2018}},
}