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Bacterial Modulation of Fc Effector Functions

Collin, Mattias LU and Kilian, Mogens (2013) p.317-332
Abstract

Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe three principally different bacterial strategies to interfere with immunoglobulins: Specific Ig binding, specific or unspecific Ig protelolysis, and, finally, specific and unspecific hydrolysis of functionally important carbohydrates on the immunoglobulins. Elucidating these bacterial immune evasion mechanism evidences bacteria-host co-evolution... (More)

Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe three principally different bacterial strategies to interfere with immunoglobulins: Specific Ig binding, specific or unspecific Ig protelolysis, and, finally, specific and unspecific hydrolysis of functionally important carbohydrates on the immunoglobulins. Elucidating these bacterial immune evasion mechanism evidences bacteria-host co-evolution and provides insight into fundamental aspects of human adaptive immunity and pathogenesis of infection.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Glycan hydrolysis, Glycosylation, Immune evasion, Immunoglobulin, Immunoglobulin binding, Proteases
host publication
Antibody Fc
pages
16 pages
publisher
Elsevier Inc.
external identifiers
  • scopus:84902435162
ISBN
9780123948021
DOI
10.1016/B978-0-12-394802-1.00018-2
language
English
LU publication?
yes
id
74edfaa0-45d1-4226-b371-bc513ea0bd8e
date added to LUP
2018-10-30 19:49:09
date last changed
2019-03-08 02:18:53
@inbook{74edfaa0-45d1-4226-b371-bc513ea0bd8e,
  abstract     = {<p>Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe three principally different bacterial strategies to interfere with immunoglobulins: Specific Ig binding, specific or unspecific Ig protelolysis, and, finally, specific and unspecific hydrolysis of functionally important carbohydrates on the immunoglobulins. Elucidating these bacterial immune evasion mechanism evidences bacteria-host co-evolution and provides insight into fundamental aspects of human adaptive immunity and pathogenesis of infection.</p>},
  author       = {Collin, Mattias and Kilian, Mogens},
  isbn         = {9780123948021},
  keyword      = {Glycan hydrolysis,Glycosylation,Immune evasion,Immunoglobulin,Immunoglobulin binding,Proteases},
  language     = {eng},
  month        = {09},
  pages        = {317--332},
  publisher    = {Elsevier Inc.},
  title        = {Bacterial Modulation of Fc Effector Functions},
  url          = {http://dx.doi.org/10.1016/B978-0-12-394802-1.00018-2},
  year         = {2013},
}