Bacterial Modulation of Fc Effector Functions
(2013) p.317-332- Abstract
Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe three principally different bacterial strategies to interfere with immunoglobulins: Specific Ig binding, specific or unspecific Ig protelolysis, and, finally, specific and unspecific hydrolysis of functionally important carbohydrates on the immunoglobulins. Elucidating these bacterial immune evasion mechanism evidences bacteria-host co-evolution... (More)
Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe three principally different bacterial strategies to interfere with immunoglobulins: Specific Ig binding, specific or unspecific Ig protelolysis, and, finally, specific and unspecific hydrolysis of functionally important carbohydrates on the immunoglobulins. Elucidating these bacterial immune evasion mechanism evidences bacteria-host co-evolution and provides insight into fundamental aspects of human adaptive immunity and pathogenesis of infection.
(Less)
- author
- Collin, Mattias LU and Kilian, Mogens
- organization
- publishing date
- 2013-09-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Glycan hydrolysis, Glycosylation, Immune evasion, Immunoglobulin, Immunoglobulin binding, Proteases
- host publication
- Antibody Fc : Linking Adaptive and Innate Immunity - Linking Adaptive and Innate Immunity
- pages
- 16 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84902435162
- ISBN
- 9780123948021
- DOI
- 10.1016/B978-0-12-394802-1.00018-2
- language
- English
- LU publication?
- yes
- id
- 74edfaa0-45d1-4226-b371-bc513ea0bd8e
- date added to LUP
- 2018-10-30 19:49:09
- date last changed
- 2022-01-31 06:40:45
@inbook{74edfaa0-45d1-4226-b371-bc513ea0bd8e, abstract = {{<p>Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe three principally different bacterial strategies to interfere with immunoglobulins: Specific Ig binding, specific or unspecific Ig protelolysis, and, finally, specific and unspecific hydrolysis of functionally important carbohydrates on the immunoglobulins. Elucidating these bacterial immune evasion mechanism evidences bacteria-host co-evolution and provides insight into fundamental aspects of human adaptive immunity and pathogenesis of infection.</p>}}, author = {{Collin, Mattias and Kilian, Mogens}}, booktitle = {{Antibody Fc : Linking Adaptive and Innate Immunity}}, isbn = {{9780123948021}}, keywords = {{Glycan hydrolysis; Glycosylation; Immune evasion; Immunoglobulin; Immunoglobulin binding; Proteases}}, language = {{eng}}, month = {{09}}, pages = {{317--332}}, publisher = {{Elsevier}}, title = {{Bacterial Modulation of Fc Effector Functions}}, url = {{http://dx.doi.org/10.1016/B978-0-12-394802-1.00018-2}}, doi = {{10.1016/B978-0-12-394802-1.00018-2}}, year = {{2013}}, }