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An electrophysiologist perspective on risk stratification in heart failure: can better understanding of the condition of the cardiac sympathetic nervous system help?

Borgquist, Rasmus LU and Singh, Jagmeet P (2015) In Journal of Nuclear Medicine 56(Suppl 4). p.59-64
Abstract
Heart failure is often complicated by arrhythmias that can adversely affect the quality of life and increase the risk for sudden cardiac death. Current risk stratification strategies for sudden cardiac death in the heart failure patient are not ideal, with much potential for further refinement. Overactivation of the sympathetic nervous system has been shown to be associated with worsening heart failure as well as arrhythmic events. Recent advances in our understanding of the autonomic nervous system and new methods for quantification of the pathologic activation of the sympathetic nerves have triggered increasing interest in this field. This viewpoint focuses on the need for and challenges of risk stratification of sudden death in the... (More)
Heart failure is often complicated by arrhythmias that can adversely affect the quality of life and increase the risk for sudden cardiac death. Current risk stratification strategies for sudden cardiac death in the heart failure patient are not ideal, with much potential for further refinement. Overactivation of the sympathetic nervous system has been shown to be associated with worsening heart failure as well as arrhythmic events. Recent advances in our understanding of the autonomic nervous system and new methods for quantification of the pathologic activation of the sympathetic nerves have triggered increasing interest in this field. This viewpoint focuses on the need for and challenges of risk stratification of sudden death in the heart failure patient and discusses the potential value of measuring sympathetic nervous system activity to better stratify risk and to select patients with heart failure for implantable cardioverter defibrillator therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
56
issue
Suppl 4
pages
59 - 64
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:26033906
  • wos:000355643200011
  • scopus:84938873225
ISSN
0161-5505
DOI
10.2967/jnumed.114.148452
language
English
LU publication?
yes
id
d07052ff-7034-442d-bcab-4fa0d10da935 (old id 7508510)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26033906?dopt=Abstract
date added to LUP
2015-07-05 06:34:28
date last changed
2017-07-30 03:15:11
@article{d07052ff-7034-442d-bcab-4fa0d10da935,
  abstract     = {Heart failure is often complicated by arrhythmias that can adversely affect the quality of life and increase the risk for sudden cardiac death. Current risk stratification strategies for sudden cardiac death in the heart failure patient are not ideal, with much potential for further refinement. Overactivation of the sympathetic nervous system has been shown to be associated with worsening heart failure as well as arrhythmic events. Recent advances in our understanding of the autonomic nervous system and new methods for quantification of the pathologic activation of the sympathetic nerves have triggered increasing interest in this field. This viewpoint focuses on the need for and challenges of risk stratification of sudden death in the heart failure patient and discusses the potential value of measuring sympathetic nervous system activity to better stratify risk and to select patients with heart failure for implantable cardioverter defibrillator therapy.},
  author       = {Borgquist, Rasmus and Singh, Jagmeet P},
  issn         = {0161-5505},
  language     = {eng},
  number       = {Suppl 4},
  pages        = {59--64},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {An electrophysiologist perspective on risk stratification in heart failure: can better understanding of the condition of the cardiac sympathetic nervous system help?},
  url          = {http://dx.doi.org/10.2967/jnumed.114.148452},
  volume       = {56},
  year         = {2015},
}