Brain Metabolism Alterations in Type 2 Diabetes : What Did We Learn From Diet-Induced Diabetes Models?
Garcia-Serrano, Alba M. LU and Duarte, João M.N. LU
(2020)
In Frontiers in Neuroscience
14.
- Abstract
Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through mechanisms that include glucose toxicity, vascular damage and blood–brain barrier (BBB) impairments, mitochondrial dysfunction, oxidative stress, brain insulin resistance, synaptic failure, neuroinflammation, and gliosis. Rodent models have been developed for investigating T2D, and have contributed to our understanding of mechanisms involved in T2D-induced brain dysfunction. Namely, mice or rats exposed to diabetogenic diets that are rich in fat and/or sugar have been widely used since they develop memory impairment, especially in tasks that depend on hippocampal processing. Here we summarize main findings on brain energy metabolism alterations underlying... (More)
Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through mechanisms that include glucose toxicity, vascular damage and blood–brain barrier (BBB) impairments, mitochondrial dysfunction, oxidative stress, brain insulin resistance, synaptic failure, neuroinflammation, and gliosis. Rodent models have been developed for investigating T2D, and have contributed to our understanding of mechanisms involved in T2D-induced brain dysfunction. Namely, mice or rats exposed to diabetogenic diets that are rich in fat and/or sugar have been widely used since they develop memory impairment, especially in tasks that depend on hippocampal processing. Here we summarize main findings on brain energy metabolism alterations underlying dysfunction of neuronal and glial cells promoted by diet-induced metabolic syndrome that progresses to a T2D phenotype.
(Less)
- author
- Garcia-Serrano, Alba M.
LU
and Duarte, João M.N.
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- brain metabolism, diet-induced obesity, glucose, high-fat, insulin resistance, sucrose
- in
- Frontiers in Neuroscience
- volume
- 14
- article number
- 229
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85083065306
- pmid:32265637
- ISSN
- 1662-4548
- DOI
- 10.3389/fnins.2020.00229
- language
- English
- LU publication?
- yes
- id
- 7529d3ba-9128-4a90-858e-95be03060c85
- date added to LUP
- 2020-04-30 12:29:59
- date last changed
- 2024-06-12 12:58:59
@article{7529d3ba-9128-4a90-858e-95be03060c85,
abstract = {{<p>Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through mechanisms that include glucose toxicity, vascular damage and blood–brain barrier (BBB) impairments, mitochondrial dysfunction, oxidative stress, brain insulin resistance, synaptic failure, neuroinflammation, and gliosis. Rodent models have been developed for investigating T2D, and have contributed to our understanding of mechanisms involved in T2D-induced brain dysfunction. Namely, mice or rats exposed to diabetogenic diets that are rich in fat and/or sugar have been widely used since they develop memory impairment, especially in tasks that depend on hippocampal processing. Here we summarize main findings on brain energy metabolism alterations underlying dysfunction of neuronal and glial cells promoted by diet-induced metabolic syndrome that progresses to a T2D phenotype.</p>}},
author = {{Garcia-Serrano, Alba M. and Duarte, João M.N.}},
issn = {{1662-4548}},
keywords = {{brain metabolism; diet-induced obesity; glucose; high-fat; insulin resistance; sucrose}},
language = {{eng}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Neuroscience}},
title = {{Brain Metabolism Alterations in Type 2 Diabetes : What Did We Learn From Diet-Induced Diabetes Models?}},
url = {{http://dx.doi.org/10.3389/fnins.2020.00229}},
doi = {{10.3389/fnins.2020.00229}},
volume = {{14}},
year = {{2020}},
}