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Prognostic impact of tumour-infiltrating B cells and plasma cells in colorectal cancer

Berntsson, Jonna LU ; Nodin, Björn LU ; Eberhard, Jakob LU ; Micke, Patrick and Jirström, Karin LU (2016) In International Journal of Cancer 139(5). p.39-1129
Abstract

Multiple studies have described associations between infiltrating immune cells and prognosis in cancer; however, the clinical relevance has most often been attributed to the T-cell linage. This study aimed to further investigate the clinicopathological correlates and prognostic impact of B cell and plasma cell infiltration in CRC. Immunohistochemical expression of CD20, CD138 and immunoglobulin kappa C (IGKC) was analysed in tissue microarrays with tumours from 557 incident cases of CRC from a prospective population-based cohort. Kaplan-Meier analysis and Cox regression analysis were used to determine the impact of CD20, CD138 and IGKC expression on 5-year overall survival. Immune cell-specific CD20, CD138, and IGKC expression... (More)

Multiple studies have described associations between infiltrating immune cells and prognosis in cancer; however, the clinical relevance has most often been attributed to the T-cell linage. This study aimed to further investigate the clinicopathological correlates and prognostic impact of B cell and plasma cell infiltration in CRC. Immunohistochemical expression of CD20, CD138 and immunoglobulin kappa C (IGKC) was analysed in tissue microarrays with tumours from 557 incident cases of CRC from a prospective population-based cohort. Kaplan-Meier analysis and Cox regression analysis were used to determine the impact of CD20, CD138 and IGKC expression on 5-year overall survival. Immune cell-specific CD20, CD138, and IGKC expression correlated significantly with lower T-stage (p < 0.001, p < 0.001, and p = 0.006, respectively). A higher density of CD20+ cells correlated significantly with an improved OS (HR = 0.53, 95% CI 0.36-0.78), remaining significant in multivariable analysis adjusted for age, TNM stage, differentiation grade and vascular invasion (HR = 0.51; 95% CI 0.33-0.80). Immune cell-specific CD138 and IGKC expression correlated significantly with an improved OS in univariable Cox regression analysis; however, these associations did not remain significant in multivariable analysis. Finally, tumour cell-specific CD138 expression was found to be an independent factor of poor prognosis (HR 1.52; 95% CI 1.03-2.24). The results from the present study demonstrate that B cell infiltration in CRC has a significant impact on tumour progression and prognosis. These findings supplement and extend the current knowledge of the immune landscape in colorectal cancer, and merit further study.

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publication status
published
subject
keywords
Journal Article
in
International Journal of Cancer
volume
139
issue
5
pages
11 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:84966440346
  • wos:000378418800018
ISSN
0020-7136
DOI
10.1002/ijc.30138
language
English
LU publication?
yes
id
75826e41-b4f8-4b81-a2cb-891ded6a5ffb
date added to LUP
2016-10-24 11:25:38
date last changed
2017-10-22 05:20:52
@article{75826e41-b4f8-4b81-a2cb-891ded6a5ffb,
  abstract     = {<p>Multiple studies have described associations between infiltrating immune cells and prognosis in cancer; however, the clinical relevance has most often been attributed to the T-cell linage. This study aimed to further investigate the clinicopathological correlates and prognostic impact of B cell and plasma cell infiltration in CRC. Immunohistochemical expression of CD20, CD138 and immunoglobulin kappa C (IGKC) was analysed in tissue microarrays with tumours from 557 incident cases of CRC from a prospective population-based cohort. Kaplan-Meier analysis and Cox regression analysis were used to determine the impact of CD20, CD138 and IGKC expression on 5-year overall survival. Immune cell-specific CD20, CD138, and IGKC expression correlated significantly with lower T-stage (p &lt; 0.001, p &lt; 0.001, and p = 0.006, respectively). A higher density of CD20+ cells correlated significantly with an improved OS (HR = 0.53, 95% CI 0.36-0.78), remaining significant in multivariable analysis adjusted for age, TNM stage, differentiation grade and vascular invasion (HR = 0.51; 95% CI 0.33-0.80). Immune cell-specific CD138 and IGKC expression correlated significantly with an improved OS in univariable Cox regression analysis; however, these associations did not remain significant in multivariable analysis. Finally, tumour cell-specific CD138 expression was found to be an independent factor of poor prognosis (HR 1.52; 95% CI 1.03-2.24). The results from the present study demonstrate that B cell infiltration in CRC has a significant impact on tumour progression and prognosis. These findings supplement and extend the current knowledge of the immune landscape in colorectal cancer, and merit further study.</p>},
  author       = {Berntsson, Jonna and Nodin, Björn and Eberhard, Jakob and Micke, Patrick and Jirström, Karin},
  issn         = {0020-7136},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {09},
  number       = {5},
  pages        = {39--1129},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Prognostic impact of tumour-infiltrating B cells and plasma cells in colorectal cancer},
  url          = {http://dx.doi.org/10.1002/ijc.30138},
  volume       = {139},
  year         = {2016},
}