New standardized cystatin C and creatinine GFR equations in children validated with inulin clearance
(2015) In Pediatric Nephrology 30(8). p.1317-1326- Abstract
- This study compares glomerular filtration rate (GFR) equations in children based on standardized cystatin C (CYSC) and creatinine (CREA) and their combinations with renal clearance of inulin (C-inulin). A total of 220 children with different renal disorders were referred for C-inulin (median 84 ml/min/1.73 m(2)). Bias, precision (interquartile range, IQR), and accuracy (percentage of estimates +/- 30 % of C-inulin; P30) were evaluated for two cystatin C equations, CAPA(CYSC) and Berg(CYSC), for creatinine equations, Schwartz(CREA) and Gao(CREA), the arithmetic mean of CAPA(CYSC) and Schwartz(CREA) (MEAN(CAPA+Schwartz)), Berg(CYSC) and Schwartz(CREA) (MEAN(BERG+SCHWARTZ)) and the composite equation Chehade(CYSC+CREA). Overall results of... (More)
- This study compares glomerular filtration rate (GFR) equations in children based on standardized cystatin C (CYSC) and creatinine (CREA) and their combinations with renal clearance of inulin (C-inulin). A total of 220 children with different renal disorders were referred for C-inulin (median 84 ml/min/1.73 m(2)). Bias, precision (interquartile range, IQR), and accuracy (percentage of estimates +/- 30 % of C-inulin; P30) were evaluated for two cystatin C equations, CAPA(CYSC) and Berg(CYSC), for creatinine equations, Schwartz(CREA) and Gao(CREA), the arithmetic mean of CAPA(CYSC) and Schwartz(CREA) (MEAN(CAPA+Schwartz)), Berg(CYSC) and Schwartz(CREA) (MEAN(BERG+SCHWARTZ)) and the composite equation Chehade(CYSC+CREA). Overall results of CAPA(CYSC), Berg(CYSC), Schwartz(CREA), Gao(CREA), MEAN(CAPA+Schwartz,) MEAN(BERG+SCHWARTZ) and Chehade(CYSC+CREA) were: median bias -7.6/-4.9/-3.7/-2.3/-4.6/-4.0/-10.1 %, IQR 20.0/19.9/21.7/22.4/21.0/20.9/23.3 ml/min/1.73 m(2) and P30 86/86/80/83/89/91/83 %. The cystatin C equations, MEAN(CAPA+Schwartz) and MEAN(BERG+SCHWARTZ) had a more stable performance across subgroups compared with Schwartz(CREA), Gao(CREA) and Chehade(CYSC+CREA). Cystatin C was the preferred filtration marker for GFR estimation in children, while the benefit of combining cystatin C and creatinine deserves further investigations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7584813
- author
- Berg, Ulla B. ; Nyman, Ulf LU ; Back, Rune ; Hansson, Magnus ; Monemi, Kajsa Asling ; Herthelius, Maria and Björk, Jonas LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Creatinine, Cystatin C, of inulin, Clearance, Renal dysfunction, Renal function, Glomerular filtration rate
- in
- Pediatric Nephrology
- volume
- 30
- issue
- 8
- pages
- 1317 - 1326
- publisher
- Springer
- external identifiers
-
- wos:000356959400014
- scopus:84933180658
- pmid:25903639
- ISSN
- 1432-198X
- DOI
- 10.1007/s00467-015-3060-3
- language
- English
- LU publication?
- yes
- id
- e3f85967-d2c7-447a-a391-4f20e6d68a83 (old id 7584813)
- date added to LUP
- 2016-04-01 12:56:54
- date last changed
- 2022-05-07 06:32:31
@article{e3f85967-d2c7-447a-a391-4f20e6d68a83, abstract = {{This study compares glomerular filtration rate (GFR) equations in children based on standardized cystatin C (CYSC) and creatinine (CREA) and their combinations with renal clearance of inulin (C-inulin). A total of 220 children with different renal disorders were referred for C-inulin (median 84 ml/min/1.73 m(2)). Bias, precision (interquartile range, IQR), and accuracy (percentage of estimates +/- 30 % of C-inulin; P30) were evaluated for two cystatin C equations, CAPA(CYSC) and Berg(CYSC), for creatinine equations, Schwartz(CREA) and Gao(CREA), the arithmetic mean of CAPA(CYSC) and Schwartz(CREA) (MEAN(CAPA+Schwartz)), Berg(CYSC) and Schwartz(CREA) (MEAN(BERG+SCHWARTZ)) and the composite equation Chehade(CYSC+CREA). Overall results of CAPA(CYSC), Berg(CYSC), Schwartz(CREA), Gao(CREA), MEAN(CAPA+Schwartz,) MEAN(BERG+SCHWARTZ) and Chehade(CYSC+CREA) were: median bias -7.6/-4.9/-3.7/-2.3/-4.6/-4.0/-10.1 %, IQR 20.0/19.9/21.7/22.4/21.0/20.9/23.3 ml/min/1.73 m(2) and P30 86/86/80/83/89/91/83 %. The cystatin C equations, MEAN(CAPA+Schwartz) and MEAN(BERG+SCHWARTZ) had a more stable performance across subgroups compared with Schwartz(CREA), Gao(CREA) and Chehade(CYSC+CREA). Cystatin C was the preferred filtration marker for GFR estimation in children, while the benefit of combining cystatin C and creatinine deserves further investigations.}}, author = {{Berg, Ulla B. and Nyman, Ulf and Back, Rune and Hansson, Magnus and Monemi, Kajsa Asling and Herthelius, Maria and Björk, Jonas}}, issn = {{1432-198X}}, keywords = {{Creatinine; Cystatin C; of inulin; Clearance; Renal dysfunction; Renal function; Glomerular filtration rate}}, language = {{eng}}, number = {{8}}, pages = {{1317--1326}}, publisher = {{Springer}}, series = {{Pediatric Nephrology}}, title = {{New standardized cystatin C and creatinine GFR equations in children validated with inulin clearance}}, url = {{http://dx.doi.org/10.1007/s00467-015-3060-3}}, doi = {{10.1007/s00467-015-3060-3}}, volume = {{30}}, year = {{2015}}, }