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Modeling of anisotropic wound healing

Valero, C.; Javierre, E.; Garcia-Aznar, J. M.; Gomez-Benito, M. J. and Menzel, Andreas LU (2015) In Journal of the Mechanics and Physics of Solids 79. p.80-91
Abstract
Biological soft tissues exhibit non-linear complex properties, the quantification of which presents a challenge. Nevertheless, these properties, such as skin anisotropy, highly influence different processes that occur in soft tissues, for instance wound healing, and thus its correct identification and quantification is crucial to understand them. Experimental and computational works are required in order to find the most precise model to replicate the tissues' properties. In this work, we present a wound healing model focused on the proliferative stage that includes angiogenesis and wound contraction in three dimensions and which relies on the accurate representation of the mechanical behavior of the skin. Thus, an anisotropic hyperelastic... (More)
Biological soft tissues exhibit non-linear complex properties, the quantification of which presents a challenge. Nevertheless, these properties, such as skin anisotropy, highly influence different processes that occur in soft tissues, for instance wound healing, and thus its correct identification and quantification is crucial to understand them. Experimental and computational works are required in order to find the most precise model to replicate the tissues' properties. In this work, we present a wound healing model focused on the proliferative stage that includes angiogenesis and wound contraction in three dimensions and which relies on the accurate representation of the mechanical behavior of the skin. Thus, an anisotropic hyperelastic model has been considered to analyze the effect of collagen fibers on the healing evolution of an ellipsoidal wound. The implemented model accounts for the contribution of the ground matrix and two mechanically equivalent families of fibers. Simulation results show the evolution of the cellular and chemical species in the wound and the wound volume evolution. Moreover, the local strain directions depend on the relative wound orientation with respect to the fibers. (C) 2015 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Wound healing, Angiogenesis, Collagen fibers, Finite element analysis, Anisotropic hyperelastic
in
Journal of the Mechanics and Physics of Solids
volume
79
pages
80 - 91
publisher
Elsevier
external identifiers
  • wos:000356733200005
  • scopus:84928551298
ISSN
1873-4782
DOI
10.1016/j.jmps.2015.03.009
language
English
LU publication?
yes
id
f6050b30-8a56-4c43-8c34-708c8deb75ff (old id 7593538)
date added to LUP
2015-07-23 08:51:30
date last changed
2017-10-29 04:00:20
@article{f6050b30-8a56-4c43-8c34-708c8deb75ff,
  abstract     = {Biological soft tissues exhibit non-linear complex properties, the quantification of which presents a challenge. Nevertheless, these properties, such as skin anisotropy, highly influence different processes that occur in soft tissues, for instance wound healing, and thus its correct identification and quantification is crucial to understand them. Experimental and computational works are required in order to find the most precise model to replicate the tissues' properties. In this work, we present a wound healing model focused on the proliferative stage that includes angiogenesis and wound contraction in three dimensions and which relies on the accurate representation of the mechanical behavior of the skin. Thus, an anisotropic hyperelastic model has been considered to analyze the effect of collagen fibers on the healing evolution of an ellipsoidal wound. The implemented model accounts for the contribution of the ground matrix and two mechanically equivalent families of fibers. Simulation results show the evolution of the cellular and chemical species in the wound and the wound volume evolution. Moreover, the local strain directions depend on the relative wound orientation with respect to the fibers. (C) 2015 Elsevier Ltd. All rights reserved.},
  author       = {Valero, C. and Javierre, E. and Garcia-Aznar, J. M. and Gomez-Benito, M. J. and Menzel, Andreas},
  issn         = {1873-4782},
  keyword      = {Wound healing,Angiogenesis,Collagen fibers,Finite element analysis,Anisotropic hyperelastic},
  language     = {eng},
  pages        = {80--91},
  publisher    = {Elsevier},
  series       = {Journal of the Mechanics and Physics of Solids},
  title        = {Modeling of anisotropic wound healing},
  url          = {http://dx.doi.org/10.1016/j.jmps.2015.03.009},
  volume       = {79},
  year         = {2015},
}