Modeling of anisotropic wound healing
(2015) In Journal of the Mechanics and Physics of Solids 79. p.80-91- Abstract
- Biological soft tissues exhibit non-linear complex properties, the quantification of which presents a challenge. Nevertheless, these properties, such as skin anisotropy, highly influence different processes that occur in soft tissues, for instance wound healing, and thus its correct identification and quantification is crucial to understand them. Experimental and computational works are required in order to find the most precise model to replicate the tissues' properties. In this work, we present a wound healing model focused on the proliferative stage that includes angiogenesis and wound contraction in three dimensions and which relies on the accurate representation of the mechanical behavior of the skin. Thus, an anisotropic hyperelastic... (More)
- Biological soft tissues exhibit non-linear complex properties, the quantification of which presents a challenge. Nevertheless, these properties, such as skin anisotropy, highly influence different processes that occur in soft tissues, for instance wound healing, and thus its correct identification and quantification is crucial to understand them. Experimental and computational works are required in order to find the most precise model to replicate the tissues' properties. In this work, we present a wound healing model focused on the proliferative stage that includes angiogenesis and wound contraction in three dimensions and which relies on the accurate representation of the mechanical behavior of the skin. Thus, an anisotropic hyperelastic model has been considered to analyze the effect of collagen fibers on the healing evolution of an ellipsoidal wound. The implemented model accounts for the contribution of the ground matrix and two mechanically equivalent families of fibers. Simulation results show the evolution of the cellular and chemical species in the wound and the wound volume evolution. Moreover, the local strain directions depend on the relative wound orientation with respect to the fibers. (C) 2015 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7593538
- author
- Valero, C. ; Javierre, E. ; Garcia-Aznar, J. M. ; Gomez-Benito, M. J. and Menzel, Andreas LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Wound healing, Angiogenesis, Collagen fibers, Finite element analysis, Anisotropic hyperelastic
- in
- Journal of the Mechanics and Physics of Solids
- volume
- 79
- pages
- 80 - 91
- publisher
- Elsevier
- external identifiers
-
- wos:000356733200005
- scopus:84928551298
- ISSN
- 1873-4782
- DOI
- 10.1016/j.jmps.2015.03.009
- language
- English
- LU publication?
- yes
- id
- f6050b30-8a56-4c43-8c34-708c8deb75ff (old id 7593538)
- date added to LUP
- 2016-04-01 14:21:08
- date last changed
- 2022-03-29 20:29:39
@article{f6050b30-8a56-4c43-8c34-708c8deb75ff,
abstract = {{Biological soft tissues exhibit non-linear complex properties, the quantification of which presents a challenge. Nevertheless, these properties, such as skin anisotropy, highly influence different processes that occur in soft tissues, for instance wound healing, and thus its correct identification and quantification is crucial to understand them. Experimental and computational works are required in order to find the most precise model to replicate the tissues' properties. In this work, we present a wound healing model focused on the proliferative stage that includes angiogenesis and wound contraction in three dimensions and which relies on the accurate representation of the mechanical behavior of the skin. Thus, an anisotropic hyperelastic model has been considered to analyze the effect of collagen fibers on the healing evolution of an ellipsoidal wound. The implemented model accounts for the contribution of the ground matrix and two mechanically equivalent families of fibers. Simulation results show the evolution of the cellular and chemical species in the wound and the wound volume evolution. Moreover, the local strain directions depend on the relative wound orientation with respect to the fibers. (C) 2015 Elsevier Ltd. All rights reserved.}},
author = {{Valero, C. and Javierre, E. and Garcia-Aznar, J. M. and Gomez-Benito, M. J. and Menzel, Andreas}},
issn = {{1873-4782}},
keywords = {{Wound healing; Angiogenesis; Collagen fibers; Finite element analysis; Anisotropic hyperelastic}},
language = {{eng}},
pages = {{80--91}},
publisher = {{Elsevier}},
series = {{Journal of the Mechanics and Physics of Solids}},
title = {{Modeling of anisotropic wound healing}},
url = {{http://dx.doi.org/10.1016/j.jmps.2015.03.009}},
doi = {{10.1016/j.jmps.2015.03.009}},
volume = {{79}},
year = {{2015}},
}