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High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study

Lewerin, C.; Johansson, H.; Lerner, U. H.; Karlsson, Magnus LU ; Lorentzon, M.; Barrett-Connor, E.; Smith, U.; Ohlsson, C. and Mellstrom, D. (2015) In Journal of Internal Medicine 278(1). p.68-76
Abstract
Objectives: Blood haemoglobin (Hb) concentration declines in elderly men, whilst the level of the adipocyte-derived protein adiponectin increases with age. The association between erythropoiesis and adiponectin in elderly men is unclear. The aim of this study was to determine whether adipokines such as adiponectin and leptin are associated with anaemia and Hb concentration in elderly community-dwelling men. Design and setting: The Gothenburg part of the population-based Swedish Osteoporotic Fractures in Men (MrOS) cohort (n=1010; median age 75.3years, range 69-81). Main outcome measures: We investigated the associations between levels of adiponectin and Hb before and after adjusting for potential confounders [i.e. age, body composition,... (More)
Objectives: Blood haemoglobin (Hb) concentration declines in elderly men, whilst the level of the adipocyte-derived protein adiponectin increases with age. The association between erythropoiesis and adiponectin in elderly men is unclear. The aim of this study was to determine whether adipokines such as adiponectin and leptin are associated with anaemia and Hb concentration in elderly community-dwelling men. Design and setting: The Gothenburg part of the population-based Swedish Osteoporotic Fractures in Men (MrOS) cohort (n=1010; median age 75.3years, range 69-81). Main outcome measures: We investigated the associations between levels of adiponectin and Hb before and after adjusting for potential confounders [i.e. age, body composition, erythropoietin (EPO), total oestradiol, leptin, cystatin C and iron and B vitamin status]. Results: In these elderly men, age was negatively associated with Hb (r=-0.12, P<0.001) and positively associated with adiponectin level (r=0.13, P<0.001). In age-adjusted partial correlations, Hb and adiponectin levels were negatively correlated (r=-0.20, P<0.001); this association remained significant after multivariable adjustment for age, body composition, EPO, fasting insulin, sex hormones, leptin and ferritin. Age-adjusted mean adiponectin concentrations were significantly higher in anaemic men (66/1005; Hb <130gL(-1)) compared to nonanaemic men (14.0 vs. 11.7 gmL(-1), P<0.05). In multivariate analysis, adiponectin together with EPO, total oestradiol, insulin, albumin, transferrin saturation, HDL cholesterol, cystatin C, total body fat mass and free thyroxine, but not leptin, explained 35% of the variation in Hb level. These results remained essentially unchanged after exclusion of men with diabetes. Conclusions: Serum adiponectin, but not leptin, was negatively and independently associated with Hb. This finding suggests a possible role of adiponectin in the age-related decline in Hb level observed in apparently healthy elderly men. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adiponectin, ageing, anaemia, haemoglobin, men
in
Journal of Internal Medicine
volume
278
issue
1
pages
68 - 76
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000356367000007
  • scopus:84930926907
ISSN
1365-2796
DOI
10.1111/joim.12340
language
English
LU publication?
yes
id
2de2a314-b934-4b82-aa5c-5e5f95012ce5 (old id 7596757)
date added to LUP
2015-08-03 10:09:45
date last changed
2017-07-30 04:02:45
@article{2de2a314-b934-4b82-aa5c-5e5f95012ce5,
  abstract     = {Objectives: Blood haemoglobin (Hb) concentration declines in elderly men, whilst the level of the adipocyte-derived protein adiponectin increases with age. The association between erythropoiesis and adiponectin in elderly men is unclear. The aim of this study was to determine whether adipokines such as adiponectin and leptin are associated with anaemia and Hb concentration in elderly community-dwelling men. Design and setting: The Gothenburg part of the population-based Swedish Osteoporotic Fractures in Men (MrOS) cohort (n=1010; median age 75.3years, range 69-81). Main outcome measures: We investigated the associations between levels of adiponectin and Hb before and after adjusting for potential confounders [i.e. age, body composition, erythropoietin (EPO), total oestradiol, leptin, cystatin C and iron and B vitamin status]. Results: In these elderly men, age was negatively associated with Hb (r=-0.12, P&lt;0.001) and positively associated with adiponectin level (r=0.13, P&lt;0.001). In age-adjusted partial correlations, Hb and adiponectin levels were negatively correlated (r=-0.20, P&lt;0.001); this association remained significant after multivariable adjustment for age, body composition, EPO, fasting insulin, sex hormones, leptin and ferritin. Age-adjusted mean adiponectin concentrations were significantly higher in anaemic men (66/1005; Hb &lt;130gL(-1)) compared to nonanaemic men (14.0 vs. 11.7 gmL(-1), P&lt;0.05). In multivariate analysis, adiponectin together with EPO, total oestradiol, insulin, albumin, transferrin saturation, HDL cholesterol, cystatin C, total body fat mass and free thyroxine, but not leptin, explained 35% of the variation in Hb level. These results remained essentially unchanged after exclusion of men with diabetes. Conclusions: Serum adiponectin, but not leptin, was negatively and independently associated with Hb. This finding suggests a possible role of adiponectin in the age-related decline in Hb level observed in apparently healthy elderly men.},
  author       = {Lewerin, C. and Johansson, H. and Lerner, U. H. and Karlsson, Magnus and Lorentzon, M. and Barrett-Connor, E. and Smith, U. and Ohlsson, C. and Mellstrom, D.},
  issn         = {1365-2796},
  keyword      = {adiponectin,ageing,anaemia,haemoglobin,men},
  language     = {eng},
  number       = {1},
  pages        = {68--76},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine},
  title        = {High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study},
  url          = {http://dx.doi.org/10.1111/joim.12340},
  volume       = {278},
  year         = {2015},
}