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Measuring density and compressibility of white blood cells and prostate cancer cells by microchannel acoustophoresis

Barnkob, Rune ; Augustsson, Per LU ; Magnusson, Cecilia LU ; Lilja, Hans LU orcid ; Laurell, Thomas LU and Bruus, Henrik (2011) 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 1. p.127-129
Abstract

We present a novel method for the determination of density and compressibility of individual particles and cells undergoing microchannel acoustophoresis in an arbitrary 2D acoustic field. Our method is a critical advancement within acoustophoretic separation of biological cells, as the ability to determine the density and compressibility of individual cells enables the prediction and alteration of the separation outcome for a given cell mixture. We apply the method on white blood cells (WBCs) and DU145 prostate cancer cells (DUCs) aiming to improve isolation of circulating tumor cells from blood, an emerging tool in the monitoring and characterizing of metastatic cancer.

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author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustophoresis, Cell handling, Micro-PIV, Ultrasound resonances
host publication
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
series title
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
volume
1
pages
127 - 129
conference name
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
conference location
Seattle, WA, United States
conference dates
2011-10-02 - 2011-10-06
external identifiers
  • scopus:84878143928
ISBN
9781618395955
language
English
LU publication?
yes
id
75991afd-683f-40c8-aca5-274cc478bbde
date added to LUP
2023-02-10 11:16:46
date last changed
2023-03-06 15:38:14
@inproceedings{75991afd-683f-40c8-aca5-274cc478bbde,
  abstract     = {{<p>We present a novel method for the determination of density and compressibility of individual particles and cells undergoing microchannel acoustophoresis in an arbitrary 2D acoustic field. Our method is a critical advancement within acoustophoretic separation of biological cells, as the ability to determine the density and compressibility of individual cells enables the prediction and alteration of the separation outcome for a given cell mixture. We apply the method on white blood cells (WBCs) and DU145 prostate cancer cells (DUCs) aiming to improve isolation of circulating tumor cells from blood, an emerging tool in the monitoring and characterizing of metastatic cancer.</p>}},
  author       = {{Barnkob, Rune and Augustsson, Per and Magnusson, Cecilia and Lilja, Hans and Laurell, Thomas and Bruus, Henrik}},
  booktitle    = {{15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011}},
  isbn         = {{9781618395955}},
  keywords     = {{Acoustophoresis; Cell handling; Micro-PIV; Ultrasound resonances}},
  language     = {{eng}},
  pages        = {{127--129}},
  series       = {{15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011}},
  title        = {{Measuring density and compressibility of white blood cells and prostate cancer cells by microchannel acoustophoresis}},
  volume       = {{1}},
  year         = {{2011}},
}