Advanced

The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders : a delineation of four potential pathways to illness

Kendler, K. S. LU ; Ohlsson, H. LU ; Keefe, R. S.E.; Sundquist, K. LU and Sundquist, J. LU (2017) In Molecular Psychiatry
Abstract

How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA—assessed from SA in siblings and cousins, and educational attainment in parents—on risk for 12 major psychiatric syndromes in 1 140 608 Swedes born 1972–1990. Four developmental patterns emerged. In the first, risk was predicted jointly by low levels of SA and high levels of FCA—that is a level of SA lower than would be predicted from the FCA. This pattern was strongest in autism spectrum disorders and schizophrenia, and weakest in bipolar... (More)

How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA—assessed from SA in siblings and cousins, and educational attainment in parents—on risk for 12 major psychiatric syndromes in 1 140 608 Swedes born 1972–1990. Four developmental patterns emerged. In the first, risk was predicted jointly by low levels of SA and high levels of FCA—that is a level of SA lower than would be predicted from the FCA. This pattern was strongest in autism spectrum disorders and schizophrenia, and weakest in bipolar illness. In these disorders, a pathologic process seems to have caused cognitive functioning to fall substantially short of familial potential. In the second pattern, seen in the internalizing conditions of major depression and anxiety disorders, risk was associated with low SA but was unrelated to FCA. Externalizing disorders—drug abuse and alcohol use disorders—demonstrated the third pattern, in which risk was predicted jointly by low SA and low FCA. The fourth pattern, seen in eating disorders, was directly opposite of that observed in externalizing disorders with risk associated with high SA and high FCA. When measured together, adolescent cognitive ability and FCA identified four developmental patterns leading to diverse psychiatric disorders. The value of cognitive assessments in psychiatric research can be substantially increased by also evaluating familial cognitive potential.Molecular Psychiatry advance online publication, 18 April 2017; doi:10.1038/mp.2017.78.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
in press
subject
in
Molecular Psychiatry
publisher
Nature Publishing Group
external identifiers
  • scopus:85017497803
ISSN
1359-4184
DOI
10.1038/mp.2017.78
language
English
LU publication?
yes
id
75bb67a1-14c2-4eb0-aef6-7e2869da42fb
date added to LUP
2017-05-04 16:31:56
date last changed
2017-05-05 03:00:03
@article{75bb67a1-14c2-4eb0-aef6-7e2869da42fb,
  abstract     = {<p>How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA—assessed from SA in siblings and cousins, and educational attainment in parents—on risk for 12 major psychiatric syndromes in 1 140 608 Swedes born 1972–1990. Four developmental patterns emerged. In the first, risk was predicted jointly by low levels of SA and high levels of FCA—that is a level of SA lower than would be predicted from the FCA. This pattern was strongest in autism spectrum disorders and schizophrenia, and weakest in bipolar illness. In these disorders, a pathologic process seems to have caused cognitive functioning to fall substantially short of familial potential. In the second pattern, seen in the internalizing conditions of major depression and anxiety disorders, risk was associated with low SA but was unrelated to FCA. Externalizing disorders—drug abuse and alcohol use disorders—demonstrated the third pattern, in which risk was predicted jointly by low SA and low FCA. The fourth pattern, seen in eating disorders, was directly opposite of that observed in externalizing disorders with risk associated with high SA and high FCA. When measured together, adolescent cognitive ability and FCA identified four developmental patterns leading to diverse psychiatric disorders. The value of cognitive assessments in psychiatric research can be substantially increased by also evaluating familial cognitive potential.Molecular Psychiatry advance online publication, 18 April 2017; doi:10.1038/mp.2017.78.</p>},
  author       = {Kendler, K. S. and Ohlsson, H. and Keefe, R. S.E. and Sundquist, K. and Sundquist, J.},
  issn         = {1359-4184},
  language     = {eng},
  month        = {04},
  publisher    = {Nature Publishing Group},
  series       = {Molecular Psychiatry},
  title        = {The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders : a delineation of four potential pathways to illness},
  url          = {http://dx.doi.org/10.1038/mp.2017.78},
  year         = {2017},
}