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COMPRENDO: Focus and approach.

Schulte-Oehlmann, U ; Albanis, T ; Allera, A ; Bachmann, J ; Berntsson, Pia LU ; Beresford, N ; Carnevali, DC ; Ciceri, F ; Dagnac, T and Falandysz, J , et al. (2006) In Environmental Health Perspectives 114(Supplement 1). p.98-100
Abstract
Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body's signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that "the dose makes the poison" may not always be the case because some EDCs do not induce the classical dose-response relationships.... (More)
Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body's signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that "the dose makes the poison" may not always be the case because some EDCs do not induce the classical dose-response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters--Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates) . (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
phylogenetic approach, wildlife exposure., molecular screening, environmental health, antiandrogens, androgens, endocrine disruptor
in
Environmental Health Perspectives
volume
114
issue
Supplement 1
pages
98 - 100
publisher
National Institute of Environmental Health Sciences
external identifiers
  • wos:000245475500015
  • scopus:39049088228
ISSN
1552-9924
DOI
10.1289/ehp.8060
language
English
LU publication?
yes
id
d55c0496-a21d-4004-9ea8-6373f0cb8ac9 (old id 760540)
alternative location
http://www.ehponline.org/members/2006/8060/8060.html
date added to LUP
2016-04-01 17:05:55
date last changed
2021-02-17 07:11:34
@article{d55c0496-a21d-4004-9ea8-6373f0cb8ac9,
  abstract     = {Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body's signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that "the dose makes the poison" may not always be the case because some EDCs do not induce the classical dose-response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters--Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates) .},
  author       = {Schulte-Oehlmann, U and Albanis, T and Allera, A and Bachmann, J and Berntsson, Pia and Beresford, N and Carnevali, DC and Ciceri, F and Dagnac, T and Falandysz, J and Galassi, S and Hala, D and Janer, G and Jeannot, R and Jobling, S and King, I and Klingmüller, D and Kloas, W and Kusk, KO and Levada, R and Lo, S and Lutz, I and Oehlmann, J and Oredsson, Stina and Porte, C and Rand-Weaver, M and Sakkas, V and Sugni, M and Tyler, C and van Aerle, R and van Ballegoy, C and Wollenberger, L},
  issn         = {1552-9924},
  language     = {eng},
  number       = {Supplement 1},
  pages        = {98--100},
  publisher    = {National Institute of Environmental Health Sciences},
  series       = {Environmental Health Perspectives},
  title        = {COMPRENDO: Focus and approach.},
  url          = {http://dx.doi.org/10.1289/ehp.8060},
  doi          = {10.1289/ehp.8060},
  volume       = {114},
  year         = {2006},
}