Advanced

Importance of factors determining the low health-related quality of life in people presenting with a diabetic foot ulcer: the Eurodialestudy

Siersma, V.; Thorsen, H.; Holstein, P. E.; Kars, M.; Apelqvist, Jan LU ; Jude, E. B.; Piaggesi, A.; Bakker, K.; Edmonds, M. and Jirkovska, A., et al. (2013) In Diabetic Medicine 30(11). p.1382-1387
Abstract
AimTo identify the factors responsible for the low health-related quality of life associated with foot ulcers and the relative importance of these factors. MethodsA total of 1232 patients with a new foot ulcer, who presented at one of the 14 centres in 10 European countries participating in the Eurodiale study, were included in this cross-sectional study. Patient and ulcer characteristics were obtained as well as results from the Euro-Qol-5D questionnaire, a health-related quality of life instrument with five domains (mobility, self-care, usual activities, pain/discomfort and anxiety/depression). To analyse the relative importance of comorbidities and ulcer- and patient-related factors for health-related quality of life, linear regression... (More)
AimTo identify the factors responsible for the low health-related quality of life associated with foot ulcers and the relative importance of these factors. MethodsA total of 1232 patients with a new foot ulcer, who presented at one of the 14 centres in 10 European countries participating in the Eurodiale study, were included in this cross-sectional study. Patient and ulcer characteristics were obtained as well as results from the Euro-Qol-5D questionnaire, a health-related quality of life instrument with five domains (mobility, self-care, usual activities, pain/discomfort and anxiety/depression). To analyse the relative importance of comorbidities and ulcer- and patient-related factors for health-related quality of life, linear regression models were used to calculate the relative contributions of each factor to the fit (R-2) of the model. ResultsPatients reported poor overall health-related quality of life, with problems primarily in the mobility and pain/discomfort domains. Among the comorbidities, the inability to stand or walk without help was the most important determinant of decreased health-related quality of life in all five domains. Among ulcer-related factors, ulcer size, limb-threatening ischaemia and elevated C-reactive protein concentration also had high importance in all domains. The clinical diagnosis of infection, peripheral arterial disease and polyneuropathy were only important in the pain/discomfort domain. ConclusionsThe factors that determine health-related quality of life are diverse and to an extent not disease-specific. To improve health-related quality of life, treatment should not only be focused on ulcer healing but a multifactorial approach by a specialized multidisciplinary team is also important. What's new? The inability to stand or walk without help is the most important determinant of poor health-related quality of life. Other factors with high importance are ulcer size, elevated C-reactive protein concentration and limb-threatening ischaemia. To improve health-related quality of life, treatment should not only be focused on ulcer healing but a multifactorial approach by a specialized multidisciplinary team is also important. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic Medicine
volume
30
issue
11
pages
1382 - 1387
publisher
Wiley-Blackwell
external identifiers
  • wos:000329269200016
  • scopus:84885915615
ISSN
1464-5491
DOI
10.1111/dme.12254
language
English
LU publication?
yes
id
760ea5f7-3d1a-422b-a03d-b55aa1506bdc (old id 4261645)
date added to LUP
2014-02-10 12:14:57
date last changed
2018-11-21 20:29:30
@article{760ea5f7-3d1a-422b-a03d-b55aa1506bdc,
  abstract     = {AimTo identify the factors responsible for the low health-related quality of life associated with foot ulcers and the relative importance of these factors. MethodsA total of 1232 patients with a new foot ulcer, who presented at one of the 14 centres in 10 European countries participating in the Eurodiale study, were included in this cross-sectional study. Patient and ulcer characteristics were obtained as well as results from the Euro-Qol-5D questionnaire, a health-related quality of life instrument with five domains (mobility, self-care, usual activities, pain/discomfort and anxiety/depression). To analyse the relative importance of comorbidities and ulcer- and patient-related factors for health-related quality of life, linear regression models were used to calculate the relative contributions of each factor to the fit (R-2) of the model. ResultsPatients reported poor overall health-related quality of life, with problems primarily in the mobility and pain/discomfort domains. Among the comorbidities, the inability to stand or walk without help was the most important determinant of decreased health-related quality of life in all five domains. Among ulcer-related factors, ulcer size, limb-threatening ischaemia and elevated C-reactive protein concentration also had high importance in all domains. The clinical diagnosis of infection, peripheral arterial disease and polyneuropathy were only important in the pain/discomfort domain. ConclusionsThe factors that determine health-related quality of life are diverse and to an extent not disease-specific. To improve health-related quality of life, treatment should not only be focused on ulcer healing but a multifactorial approach by a specialized multidisciplinary team is also important. What's new? The inability to stand or walk without help is the most important determinant of poor health-related quality of life. Other factors with high importance are ulcer size, elevated C-reactive protein concentration and limb-threatening ischaemia. To improve health-related quality of life, treatment should not only be focused on ulcer healing but a multifactorial approach by a specialized multidisciplinary team is also important.},
  author       = {Siersma, V. and Thorsen, H. and Holstein, P. E. and Kars, M. and Apelqvist, Jan and Jude, E. B. and Piaggesi, A. and Bakker, K. and Edmonds, M. and Jirkovska, A. and Mauricio, D. and Tennvall, G. Ragnarson and Reike, H. and Spraul, M. and Uccioli, L. and Urbancic, V. and van Acker, K. and van Baal, J. and Schaper, N. C.},
  issn         = {1464-5491},
  language     = {eng},
  number       = {11},
  pages        = {1382--1387},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Importance of factors determining the low health-related quality of life in people presenting with a diabetic foot ulcer: the Eurodialestudy},
  url          = {http://dx.doi.org/10.1111/dme.12254},
  volume       = {30},
  year         = {2013},
}