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Two Distinct Auditory-Motor Circuits for Monitoring Speech Production as Revealed by Content-Specific Suppression of Auditory Cortex

Ylinen, Sari; Nora, Anni; Leminen, Alina; Hakala, Tero; Huotilainen, Minna; Shtyrov, Yury LU ; Makela, Jyrki P. and Service, Elisabet (2015) In Cerebral Cortex 25(6). p.1576-1586
Abstract
Speech production, both overt and covert, down-regulates the activation of auditory cortex. This is thought to be due to forward prediction of the sensory consequences of speech, contributing to a feedback control mechanism for speech production. Critically, however, these regulatory effects should be specific to speech content to enable accurate speech monitoring. To determine the extent to which such forward prediction is content-specific, we recorded the brain's neuromagnetic responses to heard multisyllabic pseudowords during covert rehearsal in working memory, contrasted with a control task. The cortical auditory processing of target syllables was significantly suppressed during rehearsal compared with control, but only when they... (More)
Speech production, both overt and covert, down-regulates the activation of auditory cortex. This is thought to be due to forward prediction of the sensory consequences of speech, contributing to a feedback control mechanism for speech production. Critically, however, these regulatory effects should be specific to speech content to enable accurate speech monitoring. To determine the extent to which such forward prediction is content-specific, we recorded the brain's neuromagnetic responses to heard multisyllabic pseudowords during covert rehearsal in working memory, contrasted with a control task. The cortical auditory processing of target syllables was significantly suppressed during rehearsal compared with control, but only when they matched the rehearsed items. This critical specificity to speech content enables accurate speech monitoring by forward prediction, as proposed by current models of speech production. The one-to-one phonological motor-to-auditory mappings also appear to serve the maintenance of information in phonological working memory. Further findings of right-hemispheric suppression in the case of whole-item matches and left-hemispheric enhancement for last-syllable mismatches suggest that speech production is monitored by 2 auditory-motor circuits operating on different timescales: Finer grain in the left versus coarser grain in the right hemisphere. Taken together, our findings provide hemisphere-specific evidence of the interface between inner and heard speech. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
asymmetric speech monitoring, efference copy, forward prediction, magnetoencephalography (MEG), phonological working memory
in
Cerebral Cortex
volume
25
issue
6
pages
1576 - 1586
publisher
Oxford University Press
external identifiers
  • wos:000355665300016
  • scopus:84930355265
ISSN
1460-2199
DOI
10.1093/cercor/bht351
language
English
LU publication?
yes
id
63eef3e7-9f79-4e93-89d0-9b39739d0b62 (old id 7612531)
date added to LUP
2015-07-23 08:57:47
date last changed
2017-09-10 03:20:10
@article{63eef3e7-9f79-4e93-89d0-9b39739d0b62,
  abstract     = {Speech production, both overt and covert, down-regulates the activation of auditory cortex. This is thought to be due to forward prediction of the sensory consequences of speech, contributing to a feedback control mechanism for speech production. Critically, however, these regulatory effects should be specific to speech content to enable accurate speech monitoring. To determine the extent to which such forward prediction is content-specific, we recorded the brain's neuromagnetic responses to heard multisyllabic pseudowords during covert rehearsal in working memory, contrasted with a control task. The cortical auditory processing of target syllables was significantly suppressed during rehearsal compared with control, but only when they matched the rehearsed items. This critical specificity to speech content enables accurate speech monitoring by forward prediction, as proposed by current models of speech production. The one-to-one phonological motor-to-auditory mappings also appear to serve the maintenance of information in phonological working memory. Further findings of right-hemispheric suppression in the case of whole-item matches and left-hemispheric enhancement for last-syllable mismatches suggest that speech production is monitored by 2 auditory-motor circuits operating on different timescales: Finer grain in the left versus coarser grain in the right hemisphere. Taken together, our findings provide hemisphere-specific evidence of the interface between inner and heard speech.},
  author       = {Ylinen, Sari and Nora, Anni and Leminen, Alina and Hakala, Tero and Huotilainen, Minna and Shtyrov, Yury and Makela, Jyrki P. and Service, Elisabet},
  issn         = {1460-2199},
  keyword      = {asymmetric speech monitoring,efference copy,forward prediction,magnetoencephalography (MEG),phonological working memory},
  language     = {eng},
  number       = {6},
  pages        = {1576--1586},
  publisher    = {Oxford University Press},
  series       = {Cerebral Cortex},
  title        = {Two Distinct Auditory-Motor Circuits for Monitoring Speech Production as Revealed by Content-Specific Suppression of Auditory Cortex},
  url          = {http://dx.doi.org/10.1093/cercor/bht351},
  volume       = {25},
  year         = {2015},
}