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Validation Of Delayed Gadolinium-Enhanced Magnetic Resonance Imaging Of Cartilage And T2 Mapping For Quantifying Distal Metacarpus/Metatarsus Cartilage Thickness In Thoroughbred Racehorses

Carstens, Ann; Kirberger, Robert M.; Dahlberg, Leif LU ; Prozesky, Leon; Fletcher, Lizelle and Lammentausta, Eveliina LU (2013) In Veterinary Radiology & Ultrasound 54(2). p.139-148
Abstract
The purpose of this study was to determine whether delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping are accurate techniques for measuring cartilage thickness in the metacarpus3/metatarsus3 (Mc3/Mt3) of Thoroughbred racehorses. Twenty-four Mc3/Mt3 cadaver specimens were acquired from six healthy racehorses. Cartilage thickness was measured from postintra-articular Gd-DTPA2 images acquired using short tau inversion recovery (STIR), and proton density weighted (PDw) sequences, and compared with cartilage thickness measured from corresponding histologic images. Two observers performed each histologic measurement twice at three different sites, with measurement times spaced at least 5 days apart.... (More)
The purpose of this study was to determine whether delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping are accurate techniques for measuring cartilage thickness in the metacarpus3/metatarsus3 (Mc3/Mt3) of Thoroughbred racehorses. Twenty-four Mc3/Mt3 cadaver specimens were acquired from six healthy racehorses. Cartilage thickness was measured from postintra-articular Gd-DTPA2 images acquired using short tau inversion recovery (STIR), and proton density weighted (PDw) sequences, and compared with cartilage thickness measured from corresponding histologic images. Two observers performed each histologic measurement twice at three different sites, with measurement times spaced at least 5 days apart. Histologic cartilage thickness was measured at each of the three sites from the articular surface to the bonecartilage interface, and from the articular surface to the mineralized cartilage interface (tidemark). Intra-observer repeatability was good to moderate for dGEMRIC where Mc3/Mt3 cartilage was not in contact with the proximal phalanx. Where the Mc3/Mt3 cartilage was in contact with the proximal phalanx cartilage, dGEMRIC STIR and T2 mapping PDw cartilage thicknesses of Mc3/Mt3 could not be measured reliably. When measured from the articular surface to the bonecartilage interface, histologic cartilage thickness did not differ from STIR or PDw cartilage thickness at the site where the Mc3/Mt3 cartilage surface was separated from the proximal phalanx cartilage (P > 0.05). Findings indicated that dGEMRIC STIR and T2 mapping PDw are accurate techniques for measuring Mc3/Mt3 cartilage thickness at locations where the cartilage is not in direct contact with the proximal phalanx cartilage. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cartilage, dGEMRIC, horse, MRI, T2 mapping, validation
in
Veterinary Radiology & Ultrasound
volume
54
issue
2
pages
139 - 148
publisher
Wiley-Blackwell
external identifiers
  • wos:000316322800007
  • scopus:84875050134
ISSN
1058-8183
DOI
10.1111/vru.12002
language
English
LU publication?
yes
id
76314e81-1239-4d07-9e55-06774d8ee692 (old id 3765209)
date added to LUP
2013-06-03 08:41:22
date last changed
2019-03-10 03:48:15
@article{76314e81-1239-4d07-9e55-06774d8ee692,
  abstract     = {The purpose of this study was to determine whether delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping are accurate techniques for measuring cartilage thickness in the metacarpus3/metatarsus3 (Mc3/Mt3) of Thoroughbred racehorses. Twenty-four Mc3/Mt3 cadaver specimens were acquired from six healthy racehorses. Cartilage thickness was measured from postintra-articular Gd-DTPA2 images acquired using short tau inversion recovery (STIR), and proton density weighted (PDw) sequences, and compared with cartilage thickness measured from corresponding histologic images. Two observers performed each histologic measurement twice at three different sites, with measurement times spaced at least 5 days apart. Histologic cartilage thickness was measured at each of the three sites from the articular surface to the bonecartilage interface, and from the articular surface to the mineralized cartilage interface (tidemark). Intra-observer repeatability was good to moderate for dGEMRIC where Mc3/Mt3 cartilage was not in contact with the proximal phalanx. Where the Mc3/Mt3 cartilage was in contact with the proximal phalanx cartilage, dGEMRIC STIR and T2 mapping PDw cartilage thicknesses of Mc3/Mt3 could not be measured reliably. When measured from the articular surface to the bonecartilage interface, histologic cartilage thickness did not differ from STIR or PDw cartilage thickness at the site where the Mc3/Mt3 cartilage surface was separated from the proximal phalanx cartilage (P > 0.05). Findings indicated that dGEMRIC STIR and T2 mapping PDw are accurate techniques for measuring Mc3/Mt3 cartilage thickness at locations where the cartilage is not in direct contact with the proximal phalanx cartilage.},
  author       = {Carstens, Ann and Kirberger, Robert M. and Dahlberg, Leif and Prozesky, Leon and Fletcher, Lizelle and Lammentausta, Eveliina},
  issn         = {1058-8183},
  keyword      = {cartilage,dGEMRIC,horse,MRI,T2 mapping,validation},
  language     = {eng},
  number       = {2},
  pages        = {139--148},
  publisher    = {Wiley-Blackwell},
  series       = {Veterinary Radiology & Ultrasound},
  title        = {Validation Of Delayed Gadolinium-Enhanced Magnetic Resonance Imaging Of Cartilage And T2 Mapping For Quantifying Distal Metacarpus/Metatarsus Cartilage Thickness In Thoroughbred Racehorses},
  url          = {http://dx.doi.org/10.1111/vru.12002},
  volume       = {54},
  year         = {2013},
}