The hidden epidemic : Uncovering incidental fatty liver disease and its metabolic comorbidities by datamining in a hospital data lake – A real-world cohort study
Karhiaho, Iiro P. ; Kurki, Samu H. ; Parviainen, Helka I. ; Kullamaa, Liisa ; Färkkilä, Martti A. ; Matikainen, Niina and Tuomi, Tiinamaija LU
(2024)
In Diabetes Research and Clinical Practice
210.
- Abstract
Aims: To identify individuals with incidental fatty liver disease (FLD), and to evaluate its prevalence, metabolic co-morbidities and impact on follow-up. Methods: We leveraged the data-lake of Helsinki Uusimaa Hospital district (Finland) with a population of 1.7 million (specialist and primary care). A phrase recognition script on abdominal imaging reports (2008–2020) identified/excluded FLD or cirrhosis; we extracted ICD-codes, laboratory and BMI data. Results: Excluding those with other liver diseases, the prevalence of FLD was 29% (steatosis yes/no, N=61,271/155,521; cirrhosis, N=3502). The false positive and negative rates were 5–6%. Only 1.6% of the FLD cases had the ICD code recorded and 32% had undergone full clinical evaluation... (More)
Aims: To identify individuals with incidental fatty liver disease (FLD), and to evaluate its prevalence, metabolic co-morbidities and impact on follow-up. Methods: We leveraged the data-lake of Helsinki Uusimaa Hospital district (Finland) with a population of 1.7 million (specialist and primary care). A phrase recognition script on abdominal imaging reports (2008–2020) identified/excluded FLD or cirrhosis; we extracted ICD-codes, laboratory and BMI data. Results: Excluding those with other liver diseases, the prevalence of FLD was 29% (steatosis yes/no, N=61,271/155,521; cirrhosis, N=3502). The false positive and negative rates were 5–6%. Only 1.6% of the FLD cases had the ICD code recorded and 32% had undergone full clinical evaluation for associated co-morbidities. Of the 35–65-year-old individuals with FLD, 20% had diabetes, 42% prediabetes and 28% a high liver fibrosis index. FLD was independently predicted by diabetes (OR 1.56, CI 1.46–1.66, p = 2.3 * 10^-41), BMI (1.46, 1.42–1.50, p = 1.7 * 10^-154) and plasma triglyceride level (1.5, 1.43–1.57, p = 3.5 * 10^-68). Alanine aminotransferase level mildly increased (1.12, 1.08–1.16, p = 2.2 * 10^-9) and high age decreased the risk (0.92, 0.89–0.94, p = 4.65*10^-09). Half of the cases had normal ALT. Conclusions: The incidental radiological finding of FLD is reliable and associated with metabolic risks but largely ignored, although it should lead to metabolic and hepatic follow-up.
(Less)
- author
- Karhiaho, Iiro P.
; Kurki, Samu H.
; Parviainen, Helka I.
; Kullamaa, Liisa
; Färkkilä, Martti A.
; Matikainen, Niina
and Tuomi, Tiinamaija
LU
- organization
- publishing date
- 2024-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diabetes, Dyslipidemia, Fatty liver disease, Screening
- in
- Diabetes Research and Clinical Practice
- volume
- 210
- article number
- 111609
- publisher
- Elsevier
- external identifiers
-
- pmid:38479446
- scopus:85187996781
- ISSN
- 0168-8227
- DOI
- 10.1016/j.diabres.2024.111609
- language
- English
- LU publication?
- yes
- id
- 7650c45c-7001-4f9e-929a-0faebf18d891
- date added to LUP
- 2024-04-03 08:47:53
- date last changed
- 2024-04-17 10:55:49
@article{7650c45c-7001-4f9e-929a-0faebf18d891,
abstract = {{<p>Aims: To identify individuals with incidental fatty liver disease (FLD), and to evaluate its prevalence, metabolic co-morbidities and impact on follow-up. Methods: We leveraged the data-lake of Helsinki Uusimaa Hospital district (Finland) with a population of 1.7 million (specialist and primary care). A phrase recognition script on abdominal imaging reports (2008–2020) identified/excluded FLD or cirrhosis; we extracted ICD-codes, laboratory and BMI data. Results: Excluding those with other liver diseases, the prevalence of FLD was 29% (steatosis yes/no, N=61,271/155,521; cirrhosis, N=3502). The false positive and negative rates were 5–6%. Only 1.6% of the FLD cases had the ICD code recorded and 32% had undergone full clinical evaluation for associated co-morbidities. Of the 35–65-year-old individuals with FLD, 20% had diabetes, 42% prediabetes and 28% a high liver fibrosis index. FLD was independently predicted by diabetes (OR 1.56, CI 1.46–1.66, p = 2.3 * 10^-41), BMI (1.46, 1.42–1.50, p = 1.7 * 10^-154) and plasma triglyceride level (1.5, 1.43–1.57, p = 3.5 * 10^-68). Alanine aminotransferase level mildly increased (1.12, 1.08–1.16, p = 2.2 * 10^-9) and high age decreased the risk (0.92, 0.89–0.94, p = 4.65*10^-09). Half of the cases had normal ALT. Conclusions: The incidental radiological finding of FLD is reliable and associated with metabolic risks but largely ignored, although it should lead to metabolic and hepatic follow-up.</p>}},
author = {{Karhiaho, Iiro P. and Kurki, Samu H. and Parviainen, Helka I. and Kullamaa, Liisa and Färkkilä, Martti A. and Matikainen, Niina and Tuomi, Tiinamaija}},
issn = {{0168-8227}},
keywords = {{Diabetes; Dyslipidemia; Fatty liver disease; Screening}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Diabetes Research and Clinical Practice}},
title = {{The hidden epidemic : Uncovering incidental fatty liver disease and its metabolic comorbidities by datamining in a hospital data lake – A real-world cohort study}},
url = {{http://dx.doi.org/10.1016/j.diabres.2024.111609}},
doi = {{10.1016/j.diabres.2024.111609}},
volume = {{210}},
year = {{2024}},
}