Antimicrobial resistance surveillance of Bacteroides fragilis isolated from blood cultures, Europe, 2022 (ReSuBacfrag)
Buhl, Michael E.J. ; Sunnerhagen, Torgny LU
; Join-Lambert, Olivier
; Morris, Trefor
; Jeverica, Samo
; Assous, Marc V.
; Toprak, Nurver U.
; Alcalá-Hernandez, Luis
; Lienhard, Reto
and Veloo, Alida C.M.
, et al.
(2024)
In International Journal of Antimicrobial Agents
- Abstract
- Background
Bacteroides fragilis is the most frequent cause of anaerobic bacteraemia. Although recent data suggest a rise in antimicrobial resistance (AMR) of this and other anaerobic bacteria, surveillance remains limited due to a lack of both data availability and comparability. However, a newly introduced standardised method for antimicrobial susceptibility testing (AST) of anaerobic bacteria has made larger scale surveillance possible for the first time.
Aim
To investigate phenotypic AMR of Bacteroides fragilis isolates from bacteraemia across Europe in 2022.
Methods
In a multicentre approach, clinical microbiology laboratories in Europe were invited to contribute results of AST for Bacteroides... (More) - Background
Bacteroides fragilis is the most frequent cause of anaerobic bacteraemia. Although recent data suggest a rise in antimicrobial resistance (AMR) of this and other anaerobic bacteria, surveillance remains limited due to a lack of both data availability and comparability. However, a newly introduced standardised method for antimicrobial susceptibility testing (AST) of anaerobic bacteria has made larger scale surveillance possible for the first time.
Aim
To investigate phenotypic AMR of Bacteroides fragilis isolates from bacteraemia across Europe in 2022.
Methods
In a multicentre approach, clinical microbiology laboratories in Europe were invited to contribute results of AST for Bacteroides fragilis blood culture isolates (including only the first isolate per patient and year). AST of a selection of four antibiotics was performed locally by participating laboratories in a prospective or retrospective manner, using the new EUCAST disc diffusion method on fastidious anaerobe agar (FAA-HB).
Results
A total of 16 European countries reported antimicrobial susceptibilities in 449 unique isolates of Bacteroides fragilis from blood cultures in 2022. Clindamycin demonstrated the highest resistance rates (20.9%, range 0 - 63.6%), followed by piperacillin-tazobactam (11.1%, 0 - 54.5%), meropenem (13.4%, 0 - 45.5%), and metronidazole (1.8%, 0 - 20.0%), all with wide variation between countries.
Conclusion
Considering that the mean resistance rates across Europe were higher than expected for three of the four anti-anaerobic antibiotics under surveillance, both local AST of clinically relevant isolates of Bacteroides fragilis and continued surveillance on an international level is warranted. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7657521c-1fc2-4d11-804c-c1d386f35f6f
- author
- Buhl, Michael E.J.
; Sunnerhagen, Torgny
LU
; Join-Lambert, Olivier
; Morris, Trefor
; Jeverica, Samo
; Assous, Marc V.
; Toprak, Nurver U.
; Alcalá-Hernandez, Luis
; Lienhard, Reto
and Veloo, Alida C.M.
, et al. (More)
- Buhl, Michael E.J.
; Sunnerhagen, Torgny
LU
; Join-Lambert, Olivier
; Morris, Trefor
; Jeverica, Samo
; Assous, Marc V.
; Toprak, Nurver U.
; Alcalá-Hernandez, Luis
; Lienhard, Reto
; Veloo, Alida C.M.
; Cruz, Hugo
; Sóki, József
; Novak, Anita
; Mazzariol, Annarita
; Wybo, Ingrid
; Dumont, Yann
and Justesen, Ulrik s.
(Less)
- author collaboration
- organization
- publishing date
- 2024-06-27
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- Antimicrobial resistance surveillance, Resistance rate, Bacteroides fragilis, Anaerobic bacteraemia, invasive isolates, Bloodstream infection
- in
- International Journal of Antimicrobial Agents
- article number
- 107241
- pages
- 17 pages
- publisher
- Elsevier
- ISSN
- 1872-7913
- DOI
- 10.1016/j.ijantimicag.2024.107241
- language
- English
- LU publication?
- yes
- id
- 7657521c-1fc2-4d11-804c-c1d386f35f6f
- alternative location
- https://linkinghub.elsevier.com/retrieve/pii/S0924857924001596
- date added to LUP
- 2024-06-27 19:59:43
- date last changed
- 2024-07-02 03:02:05
@article{7657521c-1fc2-4d11-804c-c1d386f35f6f,
abstract = {{Background<br/><br/>Bacteroides fragilis is the most frequent cause of anaerobic bacteraemia. Although recent data suggest a rise in antimicrobial resistance (AMR) of this and other anaerobic bacteria, surveillance remains limited due to a lack of both data availability and comparability. However, a newly introduced standardised method for antimicrobial susceptibility testing (AST) of anaerobic bacteria has made larger scale surveillance possible for the first time.<br/><br/>Aim<br/><br/>To investigate phenotypic AMR of Bacteroides fragilis isolates from bacteraemia across Europe in 2022.<br/>Methods<br/><br/>In a multicentre approach, clinical microbiology laboratories in Europe were invited to contribute results of AST for Bacteroides fragilis blood culture isolates (including only the first isolate per patient and year). AST of a selection of four antibiotics was performed locally by participating laboratories in a prospective or retrospective manner, using the new EUCAST disc diffusion method on fastidious anaerobe agar (FAA-HB).<br/>Results<br/><br/>A total of 16 European countries reported antimicrobial susceptibilities in 449 unique isolates of Bacteroides fragilis from blood cultures in 2022. Clindamycin demonstrated the highest resistance rates (20.9%, range 0 - 63.6%), followed by piperacillin-tazobactam (11.1%, 0 - 54.5%), meropenem (13.4%, 0 - 45.5%), and metronidazole (1.8%, 0 - 20.0%), all with wide variation between countries.<br/>Conclusion<br/><br/>Considering that the mean resistance rates across Europe were higher than expected for three of the four anti-anaerobic antibiotics under surveillance, both local AST of clinically relevant isolates of Bacteroides fragilis and continued surveillance on an international level is warranted.}},
author = {{Buhl, Michael E.J. and Sunnerhagen, Torgny and Join-Lambert, Olivier and Morris, Trefor and Jeverica, Samo and Assous, Marc V. and Toprak, Nurver U. and Alcalá-Hernandez, Luis and Lienhard, Reto and Veloo, Alida C.M. and Cruz, Hugo and Sóki, József and Novak, Anita and Mazzariol, Annarita and Wybo, Ingrid and Dumont, Yann and Justesen, Ulrik s.}},
issn = {{1872-7913}},
keywords = {{Antimicrobial resistance surveillance; Resistance rate; Bacteroides fragilis; Anaerobic bacteraemia; invasive isolates; Bloodstream infection}},
language = {{eng}},
month = {{06}},
publisher = {{Elsevier}},
series = {{International Journal of Antimicrobial Agents}},
title = {{Antimicrobial resistance surveillance of Bacteroides fragilis isolated from blood cultures, Europe, 2022 (ReSuBacfrag)}},
url = {{http://dx.doi.org/10.1016/j.ijantimicag.2024.107241}},
doi = {{10.1016/j.ijantimicag.2024.107241}},
year = {{2024}},
}