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The effect of gossypol on fast axonal transport and microtubule assembly

Kanje, Martin LU ; Ekström, Per LU ; Deinum, Johanna and Wallin, Margareta (1986) In Biochimica et Biophysica Acta - Biomembranes 856(3). p.437-442
Abstract

Gossypol at micromolar concentrations (2 μM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 μM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the results indicate that gossypol may act as a potent neurotoxin.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Axonal transport, Gossypol, Microtubule assembly
in
Biochimica et Biophysica Acta - Biomembranes
volume
856
issue
3
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:0022541749
  • pmid:2421770
ISSN
0005-2736
DOI
10.1016/0005-2736(86)90134-3
language
English
LU publication?
yes
id
7678f1fb-3db8-4df1-aab0-ae66e6f20246
date added to LUP
2016-12-07 14:28:06
date last changed
2025-01-12 17:04:36
@article{7678f1fb-3db8-4df1-aab0-ae66e6f20246,
  abstract     = {{<p>Gossypol at micromolar concentrations (2 μM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 μM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the results indicate that gossypol may act as a potent neurotoxin.</p>}},
  author       = {{Kanje, Martin and Ekström, Per and Deinum, Johanna and Wallin, Margareta}},
  issn         = {{0005-2736}},
  keywords     = {{Axonal transport; Gossypol; Microtubule assembly}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{3}},
  pages        = {{437--442}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta - Biomembranes}},
  title        = {{The effect of gossypol on fast axonal transport and microtubule assembly}},
  url          = {{http://dx.doi.org/10.1016/0005-2736(86)90134-3}},
  doi          = {{10.1016/0005-2736(86)90134-3}},
  volume       = {{856}},
  year         = {{1986}},
}