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The effect of gossypol on fast axonal transport and microtubule assembly

Kanje, Martin LU ; Ekström, Per LU ; Deinum, Johanna and Wallin, Margareta (1986) In Biochimica et Biophysica Acta - Biomembranes 856(3). p.437-442
Abstract

Gossypol at micromolar concentrations (2 μM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 μM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the results indicate that gossypol may act as a potent neurotoxin. © 1986.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Axonal transport, Gossypol, Microtubule assembly
in
Biochimica et Biophysica Acta - Biomembranes
volume
856
issue
3
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:0022541749
ISSN
0005-2736
DOI
10.1016/0005-2736(86)90134-3
language
English
LU publication?
yes
id
7678f1fb-3db8-4df1-aab0-ae66e6f20246
date added to LUP
2016-12-07 14:28:06
date last changed
2017-09-10 05:12:53
@article{7678f1fb-3db8-4df1-aab0-ae66e6f20246,
  abstract     = {<p>Gossypol at micromolar concentrations (2 μM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 μM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the results indicate that gossypol may act as a potent neurotoxin. © 1986.</p>},
  author       = {Kanje, Martin and Ekström, Per and Deinum, Johanna and Wallin, Margareta},
  issn         = {0005-2736},
  keyword      = {Axonal transport,Gossypol,Microtubule assembly},
  language     = {eng},
  month        = {04},
  number       = {3},
  pages        = {437--442},
  publisher    = {Elsevier},
  series       = {Biochimica et Biophysica Acta - Biomembranes},
  title        = {The effect of gossypol on fast axonal transport and microtubule assembly},
  url          = {http://dx.doi.org/10.1016/0005-2736(86)90134-3},
  volume       = {856},
  year         = {1986},
}