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Decay of connection probabilities with distance in 2D and 3D neuronal networks

Goriachkin, Vasilii LU orcid and Turova, Tatyana LU (2019) In BioSystems 184.
Abstract

We study connectivity in a model of a growing neuronal network in dimensions 2 and 3. Although the axon-to-dendrite proximity is an insufficient condition for establishing a functional synapse, it is still a necessary one. Therefore we study connection probabilities at short distances between the randomly grown axon trees and somas as probabilities of potential connections between the corresponding neurons. Our results show that, contrary to a common belief, these probabilities do not necessarily decay polynomially or exponentially in distance, but there are regimes of parameter values when the probability of proximity is not sensitive to the distance. In particular, in 3 dimensions the Euclidean distance between the neuronal cell body... (More)

We study connectivity in a model of a growing neuronal network in dimensions 2 and 3. Although the axon-to-dendrite proximity is an insufficient condition for establishing a functional synapse, it is still a necessary one. Therefore we study connection probabilities at short distances between the randomly grown axon trees and somas as probabilities of potential connections between the corresponding neurons. Our results show that, contrary to a common belief, these probabilities do not necessarily decay polynomially or exponentially in distance, but there are regimes of parameter values when the probability of proximity is not sensitive to the distance. In particular, in 3 dimensions the Euclidean distance between the neuronal cell body centers of neurons seems to play a very subtle role, as the probabilities of connections are practically constant within a certain finite range of distance. The model has a sufficient number of parameters to assess networks of neurons of different types. Our results give a firm basis for further modelling of the neuronal connectivity taking into account some realistic bouton distributions for establishing synaptic connections.

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author
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organization
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type
Contribution to journal
publication status
published
subject
keywords
Connection probabilities, Random graphs, Randomly grown network
in
BioSystems
volume
184
article number
103991
publisher
Elsevier
external identifiers
  • pmid:31351994
  • scopus:85071008639
ISSN
0303-2647
DOI
10.1016/j.biosystems.2019.103991
project
Critical Scaling in Particle Systems and Random Graphs
language
English
LU publication?
yes
id
76d5f6c0-8d33-49de-bf9c-b3a66faf51b6
date added to LUP
2019-09-09 13:16:15
date last changed
2024-10-02 12:16:00
@article{76d5f6c0-8d33-49de-bf9c-b3a66faf51b6,
  abstract     = {{<p>We study connectivity in a model of a growing neuronal network in dimensions 2 and 3. Although the axon-to-dendrite proximity is an insufficient condition for establishing a functional synapse, it is still a necessary one. Therefore we study connection probabilities at short distances between the randomly grown axon trees and somas as probabilities of potential connections between the corresponding neurons. Our results show that, contrary to a common belief, these probabilities do not necessarily decay polynomially or exponentially in distance, but there are regimes of parameter values when the probability of proximity is not sensitive to the distance. In particular, in 3 dimensions the Euclidean distance between the neuronal cell body centers of neurons seems to play a very subtle role, as the probabilities of connections are practically constant within a certain finite range of distance. The model has a sufficient number of parameters to assess networks of neurons of different types. Our results give a firm basis for further modelling of the neuronal connectivity taking into account some realistic bouton distributions for establishing synaptic connections.</p>}},
  author       = {{Goriachkin, Vasilii and Turova, Tatyana}},
  issn         = {{0303-2647}},
  keywords     = {{Connection probabilities; Random graphs; Randomly grown network}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{BioSystems}},
  title        = {{Decay of connection probabilities with distance in 2D and 3D neuronal networks}},
  url          = {{http://dx.doi.org/10.1016/j.biosystems.2019.103991}},
  doi          = {{10.1016/j.biosystems.2019.103991}},
  volume       = {{184}},
  year         = {{2019}},
}